Origin
LEC rats which had high X-ray susceptibility were backcrossed to F344. In every generation, highly X-ray susceptible rats were selectied with the radiation susceptibility assay. 2 strains (F344.LEC-xhs1/1Nrs (NBRP No.0293) and F344.LEC-xhs1/2Nrs (NBRP No.0294)) were established in N17.
References
Tsuji AB, Sugyo A, Sudo H, Sagara M, Ishikawa A, Ohtsuki M, Kimura T, Ogiu T, Miyagishi M, Taira K, Imai T, Harada YN.
Defective repair of radiation-induced DNA damage is complemented by a CHORI-230-65K18 BAC clone on rat chromosome 4.
Genomics. 2006 Feb;87(2):236-42.
Tsuji AB, Sugyo A, Ogiu T, Sagara M, Kimura T, Ishikawa A, Sudo H, Ohtsuki M, Aburatani H, Imai T, Harada YN.
Fine mapping of radiation susceptibility and gene expression analysis of LEC congenic rat lines.
Genomics. 2005 Sep;86(3):271-9.
Ogiu T, Nishimura M, Watanabe F, Ukai H, Ishii-Ohba H, Shimada Y, Tsuji H, Sakurai J, Hino O.
Absence of linkage between radiosensitivity and the predisposing atp7b gene mutation for heritable hepatitis in the LEC rat.
Radiat Res. 2000 Jul;154(1):113-6.