Japanese
 NBRP Rat No: 0294 Strain NameF344.LEC-xhs1/2Nrs Commmon Name: PFC
 Principal Investigator  Yoshi-nobu Harada
 Organization   National Institute of Radiological Sciences RadGenomics Project
 Address  4-9-1, Anagawa, Inage-ku, Chiba-shi

263-8555 Chiba

 Japan
 Telephone  043-206-4642  Fax:  043-206-4138  y_harada@nirs.go.jp
 Inbred Generations   N17F20 (May 2009) 
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin LEC rats which had high X-ray susceptibility were backcrossed to F344. In every generation, highly X-ray susceptible rats were selectied with the radiation susceptibility assay. 2 strains (F344.LEC-<i>xhs1</i>/1Nrs (NBRP No.0293) and F344.LEC-<i>xhs1</i>/2Nrs (NBRP No.0294)) were established in N17. 
 Strain Characteristics  
 Breeding Conditions  
 Genotyping  
 References  Tsuji AB, Sugyo A, Sudo H, Sagara M, Ishikawa A, Ohtsuki M, Kimura T, Ogiu T, Miyagishi M, Taira K, Imai T, Harada YN.
Defective repair of radiation-induced DNA damage is complemented by a CHORI-230-65K18 BAC clone on rat chromosome 4.
Genomics. 2006 Feb;87(2):236-42.

Tsuji AB, Sugyo A, Ogiu T, Sagara M, Kimura T, Ishikawa A, Sudo H, Ohtsuki M, Aburatani H, Imai T, Harada YN.
Fine mapping of radiation susceptibility and gene expression analysis of LEC congenic rat lines.
Genomics. 2005 Sep;86(3):271-9.

Ogiu T, Nishimura M, Watanabe F, Ukai H, Ishii-Ohba H, Shimada Y, Tsuji H, Sakurai J, Hino O.
Absence of linkage between radiosensitivity and the predisposing atp7b gene mutation for heritable hepatitis in the LEC rat.
Radiat Res. 2000 Jul;154(1):113-6.