NBRP Rat No: 0001 Strain NameACI/NKyo Commmon Name: August Copenhagen Irish
 Principal Investigator  Tadao Serikawa
 Organization   Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
 Address  Yoshidakonoe-cho, Sakyo-ku

606-8501 Kyoto

 Telephone  075-753-4360  Fax:  075-753-4409  serikawa@anim.med.kyoto-u.ac.jp
 Inbred Generations   F143+73 (March 2012) 
 Coat Color
 Deposition Status
 agouti (A,B,hi)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Origin NIH (1988, F143) > Kyo (F43) 
 Strain Characteristics Spontaneous tumours 46% testes, 16% adrenal, 5% pituitary, 6% skin and ear duct and fewer of other types in males; 21% pituitary, 13% uterus, 11% mammary gland, 6% adrenal and fewer of other types in females. Other conditions include 28% of males and 20% of females with absent, hypoplastic or cystic kidneys on one side sometimes associated with an absent or defective uterine horn or atrophic testes on the same side (Maekawa and Odashima 1975). These abnormalities have a polygenic mode of inheritance (Cramer and Gill 1975).  
 Breeding Conditions Usually good breeding performance but reduce litter size in case of females with agenesis of the uterine horn. 
 References  Ueta H, Kitazawa Y, Sawanobori Y, Ueno T, Ueha S, Matsushima K, Matsuno K.
Single blood transfusion induces the production of donor-specific alloantibodies and regulatory T cells mainly in the spleen.
Int Immunol. 2018 Jan 18. [Epub ahead of print]

Kuramoto T, Nakanishi S, Ochiai M, Nakagama H, Voigt B, Serikawa T.<br />
Origins of Albino and Hooded Rats: Implications from Molecular Genetic Analysis across Modern Laboratory Rat Strains.<br />
PLoS One. 2012;7(8):e43059.<br />

Kuramoto T, Yokoe M, Hashimoto R, Hiai H, Serikawa T.<br />
A rat model of hypohidrotic ectodermal dysplasia carries a missense mutation in the Edaradd gene.<br />
BMC Genetics 12:91, 2011<br />
<br />
Matsuno K, Ueta H, Shu Z, Xue-Dong X, Sawanobori Y, Kitazawa Y, Bin Y, Yamashita M, Shi C.<br />
The microstructure of secondary lymphoid organs that support immune cell trafficking.<br />
Arch Histol Cytol. 2010;73(1):1-21. Review.<br /><br />

LinksShull JD, Lachel CM, Strecker TE, Spady TJ, Tochacek M, Pennington KL, Murrin CR, Meza JL, Schaffer BS, Flood LA, Gould KA.<br />
Genetic bases of renal agenesis in the ACI rat: mapping of Renag1 to chromosome 14.<br />
Mamm Genome. 17(7):751-9, 2006.