Japanese
 NBRP Rat No: 0354 Strain Name: TM.KDP-Cblb/Nyo Commmon Name: TM.KDP-<i>Cblb</i>, TM.KDP-Cblb congenic
 Principal Investigator  Susumu Seino
 Organization   Kobe University Graduate School of Medicine 
 Address  7-5-1 Kusunoki-cho, Chuou-Ku, Kobe

650-0017 Hyogo

  Japan
 Telephone  078-382-5364  Fax:  078-382-5379  seino@med.kobe-u.ac.jp, yokoi@med.kobe-u.ac.jp
 Inbred Generations   N7F8 
   
 Coat Color
 Deposition Status
 
 a,B,C,h,P,r
  Embryo      Sperm      Live Animals
 Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.The recipients shall cite the references of the resource and acknowledge the developer as the source of the resource in the publications. Depending on the project of the recipients, a collaborative arrangement with the developer could be required. In this case, the recipients shall discuss with the developer.  
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Cblb: Casitas B-lineage lymphoma b
 Origin  
 Strain Characteristics insulitis 
 Breeding Conditions Homozygous Cblb rats are usually infertile in both sexes and are therefore maintained by crossing heterozygous individuals (segregating inbred strain). 
 Genotyping  
 References  Yokoi N, Komeda K, Wang HY, Yano H, Kitada K, Saitoh Y, Seino Y, Yasuda K, Serikawa T, Seino S.
Cblb is a major susceptibility gene for rat type 1 diabetes mellitus.
Nat Genet. 31(4):391-4, 2002

Yokoi N, Namae M, Fuse M, Wang HY, Hirata T, Seino S, Komeda K.
Establishment and characterization of the Komeda diabetes-prone rat as a segregating inbred strain.
Exp Anim. 52(4):295-301, 2003