Japanese
NBRP Rat No: 0440
Strain Name
:
KCI/Kyo
Commmon Name: KCI, Kyoto circling rat, MCI
Principal Investigator
Tadao Serikawa
Organization
Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
Address
Yoshidakonoe-cho, Sakyo-ku
606-8501 Kyoto
JAPAN
Telephone
075-753-4360
Fax: 075-753-4409
serikawa@anim.med.kyoto-u.ac.jp
Inbred Generations
Coat Color
Deposition Status
albino (c)
Embryo
Sperm
Live Animals
Usage Restrictions
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Others
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio- Hypertension
Oncology
Metabolism
Otorhinology
Immunology
Infectious Disease
Osteology
Internal Medicine
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Others
Control Strains
Reporter gene Strains
Gene
Pcdh15: protocadherin 15
Origin
Rats showing abnormal behaviors characterized by constant circling movements were found in the F3 generation of Crl:CD(SD) rats purchased from Charles River Laboratory Japan in 2003.
Strain Characteristics
Homozygous KCI rats display circling and abnormal swimming behaviors along with the lack of an auditory-evoked brainstem response at the highest intensities of acoustic stimulation. The mutation on the kci allele is a nonsense mutation and is predicted to result in truncated PCDH15 protein at the 9th domain of extracellular cadherin domains. Histological study revealed severe reduction of the cochlear hair cells and the ganglion cells in the adult KCI rats.
Breeding Conditions
Heterozygous female and homozygous male are mated.
Genotyping
References
Naoi K, Kuramoto T, Kuwamura Y, Gohma H, Kuwamura M, Serikawa T.
Characterization of the Kyoto Circling (KCI) rat carrying a spontaneous nonsense mutation in the protocadherin 15 (Pcdh15) gene.
Exp Anim 58(1):1-10, 2009.