Japanese
 NBRP Rat No: 0440 Strain NameKCI/Kyo Commmon Name: KCI, Kyoto circling rat, MCI
 Principal Investigator  Tadao Serikawa
 Organization   Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
 Address  Yoshidakonoe-cho, Sakyo-ku

606-8501 Kyoto

 JAPAN
 Telephone  075-753-4360  Fax:  075-753-4409  serikawa@anim.med.kyoto-u.ac.jp
 Inbred Generations    
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.  
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Pcdh15: protocadherin 15
 Origin Rats showing abnormal behaviors characterized by constant circling movements were found in the F3 generation of Crl:CD(SD) rats purchased from Charles River Laboratory Japan in 2003. 
 Strain Characteristics Homozygous KCI rats display circling and abnormal swimming behaviors along with the lack of an auditory-evoked brainstem response at the highest intensities of acoustic stimulation. The mutation on the kci allele is a nonsense mutation and is predicted to result in truncated PCDH15 protein at the 9th domain of extracellular cadherin domains. Histological study revealed severe reduction of the cochlear hair cells and the ganglion cells in the adult KCI rats. 
 Breeding Conditions Heterozygous female and homozygous male are mated. 
 Genotyping  
 References  Naoi K, Kuramoto T, Kuwamura Y, Gohma H, Kuwamura M, Serikawa T.
Characterization of the Kyoto Circling (KCI) rat carrying a spontaneous nonsense mutation in the protocadherin 15 (Pcdh15) gene.
Exp Anim 58(1):1-10, 2009.