Japanese
 NBRP Rat No: Strain Name: ZI/Kyo(F) Commmon Name: zitter rat
 Principal Investigator  Tadao Serikawa
 Organization   Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
 Address  Yoshidakonoe-cho, Sakyo-ku

606-8501 Kyoto

  JAPAN
 Telephone  075-753-4360  Fax:  075-753-4409  serikawa@anim.med.kyoto-u.ac.jp
 Inbred Generations   F13+10 
   
 Coat Color
 Deposition Status
 
 c
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin Zitter rat was detected in a Sprague Dawley colony (SD) in Hannover in 1978 by Rehm. 1983 introduced to Kyoto University and established ZI/Kyo.
＞東京大学医科学研究所＞（財）動物繁殖研究所＞獨協医科大学＞1999年に京都大学大学院医学研究科附属動物実験施設 
 Strain Characteristics vacuole formation, tremor 
 Breeding Conditions Good breeding performance 
 Genotyping 8 bp deletion in intron 12 of Attractin gene 
 References  T. Kuramoto, K. Kitada, T. Inui, Y. Sasaki, K. Ito, T. Hase, Y. Ogawa, K. Nakao, G.S. Barsh, M. Nagao, T. Ushijima, and T. Serikawa
Attractin/Mahogany/Zitter plays a critical role in myelination of the central nervous system.
Proc Natl Acad Sci USA, 98 (2): 559-564, 2001

Ueda S, Sakakibara S, Watanabe E, Yoshimoto K, Koibuchi N.
Vulnerability of monoaminergic neurons in the brainstem of the zitter rat in oxidative stress.
Prog Brain Res. 2002;136:293-302.

Joyce JN, Yoshimoto K, Ueda S.
The zitter mutant rat exhibits loss of D3 receptors with degeneration of the dopamine system.
Neuroreport. 2000 Jul 14;11(10):2173-5.

Ueda S, Aikawa M, Ishizuya-Oka A, Yamaoka S, Koibuchi N, Yoshimoto K.
Age-related dopamine deficiency in the mesostriatal dopamine system of zitter mutant rats: regional fiber vulnerability in the striatum and the olfactory tubercle.
Neuroscience. 2000;95(2):389-98.

Muto Y, Hayashi T, Higashi Y, Endo T, Yamamoto T, Sato K.
Age-related decrease in brain-derived neurotrophic factor gene expression in the brain of the zitter rat with genetic spongiform encephalopathy.
Neurosci Lett. 1999 Aug 20;271(2):69-72.

Ueda S, Aikawa M, Ishizuya-Oka A, Koibuchi N, Yamaoka S, Yoshimoto K.
Age-related degeneration of the serotoninergic fibers in the zitter rat brain.
Synapse. 1998 Sep;30(1):62-70.