Japanese
 NBRP Rat No: 0300 Strain Name: LEW-Tg(Gt(ROSA)26Sor-luc)21Jmsk Commmon Name: LEW-<i>Tg(Rosa-luc)21Jmsk</i>, Luc21
 Principal Investigator  Eiji Kobayashi
 Organization   Center for Molecular Medicine, Jichi Medical School Division of Organ Replacement Research
 Address  3311-1, Yakushiji, Shimono-shi, Tochigi

329-0498 Tochigi

  Japan
 Telephone  0285-58-7446  Fax:  0285-44-5365  eijikoba@jichi.ac.jp
 Inbred Generations    
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions  In publishing, the references designated by the DEPOSITOR are requested to be cited. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene luc: luciferase, firefly
 Origin This strain was established at Jichi Medical School. This transgenic rat was originated from LEW (RT1<sup>l</sup>) strain purchased from Charles River Japan. 
 Strain Characteristics This strain expresses luciferase ubiquitously driven by the gene trap ROSA 26 promoter. The strength of the transgene expression of this strain is poorer than that of luc11 (NBRP No.0299). The expression of transgene is ubiquitous except for bone-marrow cell and blood. 
 Breeding Conditions Good breeding performance. 
 Genotyping  
 References  Hata T, Uemoto S, Fujimoto Y, Murakami T, Tateno C, Yoshizato K, Kobayashi E.
Transplantation of Engineered Chimeric Liver With Autologous Hepatocytes and Xenobiotic Scaffold.
Ann Surg. 2013 Mar;257(3):542-7.

Hata T, Iwasaki J, Hishikawa S, Fujimoto Y, Uemoto S, Kobayashi E.
Development of a portocaval shunt using a small intestinal segment in rats.
Microsurgery. 2010 May;30(4):302-6.

Iwasaki J, Hata T, Hishikawa S, Fujimoto Y, Uemoto S, Murakami T, Kobayashi E.
Use of rat segmental intestine for fetal pancreatic transplantation.
Microsurgery. 2010 May;30(4):296-301.

Hakamata Y, Murakami T, Kobayashi E.
"Firefly rats" as an organ/cellular source for long-term in vivo bioluminescent imaging.
Transplantation. 27;81(8):1179-84, 2006.