Japanese
 NBRP Rat No: 0376 Strain Name: SD-Tg(HRAS)128Htsu Commmon Name: SD-<i>Tg(hHRAS)128</i>, Hras128
 Principal Investigator  Hiroyuki Tsuda
 Organization   Nagoya City University Graduate School of Medical Sciences Department of Molecular Toxicology
 Address  1 Kawasumi, Mizuho-cho Mizuho-ku, Nagoya

467-8601 Aichi

  Japan
 Telephone  052-853-8992  Fax:  052-853-8996  htsuda@med.nagoya-cu.ac.jp
 Inbred Generations    
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain prior written consent concerning usage from the DEPOSITOR. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene HRAS: v-Ha-ras Harvey rat sarcoma viral oncogene homolog [ Homo sapiens ]
 Origin This transgenic strain was generated by pronuclear injection of the transgene. 
 Strain Characteristics This strain is carrying three copies of the human c-Ha-ras proto-oncogene, including its own promoter region. The rats are extremely sensitive to the induction of mammary carcinomas induced by chemical carcinogen such as DMBA and MNU. 
 Breeding Conditions Maintained as hemizygous males. 
 Genotyping  
 References  Nohmi T, Masumura K, Toyoda-Hokaiwado N.
Transgenic rat models for mutagenesis and carcinogenesis.
Genes Environ. 2017 Feb 1;39:11.

Tsuda H, Fukamachi K, Ohshima Y, Ueda S, Matsuoka Y, Hamaguchi T, Ohnishi T, Takasuka N, Naito A.
High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis: a cancer-prone animal model.
Cancer Sci. 2005 96(6):309-16.

Asamoto M, Ochiya T, Toriyama-Baba H, Ota T, Sekiya T, Terada M, Tsuda H.
Transgenic rats carrying human c-Ha-ras proto-oncogenes are highly susceptible to N-methyl-N-nitrosourea mammary carcinogenesis.
Carcinogenesis. 2000 21(2):243-9.