Origin
Kobe university→Hokkaido University, Laboratory of Experimental Animal Science(Hok) 1975→Hokkaido University, Center for Experimental Plants & Animals(Hok) 1982, F19. Long Evans Agouti derived originally from an outbred Long Evans stock at Hokkaido University and selected for agouti coat colour (though Long Evans stock is usually fixed for non-agouti, hooded genes).
Strain characteristics
The LEA rat was established from a Long-Evans rat closed colony as the control strain of the LEC rat, which is reported to exhibit several mutant phenotypes such as hepatic disorder (hts), blockage of the T cell differentiation (thid) and X-ray hypersensitivity (xhs1 and xhs2). But LEA rat is hypersensitive to X-rays to a similar degree as the LEC rat.
Breeding Conditions
Good breeding performance. Sib-mating.
References
Shimizu Y, Yanobu-Takanashi R, Nakano K, Hamase K, Shimizu T, Okamura T.
A deletion in the Ctns gene causes renal tubular dysfunction and cystine accumulation in LEA/Tohm rats.
Mamm Genome. 2019 Feb;30(1-2):23-33.
Igarashi M, Hippo Y, Ochiai M, Fukuda H, Nakagama H.
AKT is critically involved in cooperation between obesity and the dietary carcinogen amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) toward colon carcinogenesis in rats.
Biochem Biophys Res Commun. 2013 Dec 13. pii: S0006-291X(13)02128-1.
Torigoe D, Ichii O, Dang R, Ohnaka T, Okano S, Sasaki N, Kon Y, Agui T.
High-resolution linkage mapping of the rat hooded locus.
J Vet Med Sci. 2011 May;73(5):707-10.
Agui T, Miyamoto T, Tsumagari T
X-ray hypersensitivity in the LEA rat: genetic linkage analysis of responsible loci.
Exp Anim. 50(2):147-51, 2001.