NBRP Rat No: 0041 Strain NameLEA/Hok Commmon Name: KEA, Long Evans Agouti
 Principal Investigator  Kazuhiro Kitada
 Organization   Creative Research Initiative "Sousei", Hokkaido University Laboratory of Mammalian Genetics
 Address  Kita 10 Nishi 8, Kita-ku

060-0810 Hokkaido

 Telephone  011-706-3582  Fax:  011-726-3476  kkitada@cast.hokudai.ac.jp
 Inbred Generations   F102 (Jul 2007) 
 Coat Color
 Deposition Status
 agouti (A,B,C,h)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Origin Kobe university→Hokkaido University, Laboratory of Experimental Animal Science(Hok) 1975→Hokkaido University, Center for Experimental Plants & Animals(Hok) 1982, F19. Long Evans Agouti derived originally from an outbred Long Evans stock at Hokkaido University and selected for agouti coat colour (though Long Evans stock is usually fixed for non-agouti, hooded genes).  
 Strain Characteristics The LEA rat was established from a Long-Evans rat closed colony as the control strain of the LEC rat, which is reported to exhibit several mutant phenotypes such as hepatic disorder (<i>hts</i>), blockage of the T cell differentiation (<i>thid</i>) and X-ray hypersensitivity (<i>xhs1</i> and <i>xhs2</i>). But LEA rat is hypersensitive to X-rays to a similar degree as the LEC rat. 
 Breeding Conditions Good breeding performance. Sib-mating. 
 References  Igarashi M, Hippo Y, Ochiai M, Fukuda H, Nakagama H.
AKT is critically involved in cooperation between obesity and the dietary carcinogen amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) toward colon carcinogenesis in rats.
Biochem Biophys Res Commun. 2013 Dec 13. pii: S0006-291X(13)02128-1.

Torigoe D, Ichii O, Dang R, Ohnaka T, Okano S, Sasaki N, Kon Y, Agui T.
High-resolution linkage mapping of the rat hooded locus.
J Vet Med Sci. 2011 May;73(5):707-10.

Agui T, Miyamoto T, Tsumagari T
X-ray hypersensitivity in the LEA rat: genetic linkage analysis of responsible loci.
Exp Anim. 50(2):147-51, 2001.