Origin |
F344 rats are susceptible and ACI rats are resistant to PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine)-induced ACF (aberrant crypt foci) formation (Nagao, 1998). This congenic strain was established using 'speed congenic' method by backcrossing (F344/JclxACI/N)F1 onto ACI/N, followed by intercrossing in N8 generation. Thereafter this strain is maintained by crossing homozygous individuals. (Jul 7, 2009) |