Japanese
 NBRP Rat No: 0443 Strain Name: F344-Apcm1Kyo Commmon Name: F344-<i>Apc<sup>Kyo1588</i></sup>/Kyo, Apc delta 2523, Kyoto Apc Delta rat
 Principal Investigator  Takashi Kuramoto
 Organization   Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
 Address  Yoshidakonoe-cho, Sakyo-ku

606-8501 Kyoto

  Japan
 Telephone  075-753-4494  Fax:  075-753-4409  kuramot@anim.med.kyoto-u.ac.jp
 Inbred Generations   N12 F5 (April 2012) 
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.  
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability  Japan SLC, Inc 
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Apc: adenomatous polyposis coli
 Origin Established by ENU mutagenesis (gene-driven).　Background strain: F344/NSlc 
 Strain Characteristics A point mutation　(S2523X) in <i>Apc</i> gene. This strain is an efficient rat model for colitis-associated colorectal cancer, azoxymethane and dextran sodium sulfate (AOM/DSS)-induced colon carcinogenesis  
 Breeding Conditions  
 Genotyping <a href="http://www.anim.med.kyoto-u.ac.jp/nbr/documents/PCR_Gene/Apc_m1kyo_en.pdf">Genotyping protocol for Apc</a> 
 References  Kochi T, Shimizu M, Shirakami Y, Yoshimi K, Kuramoto T, Tanaka T, Moriwaki H.
Utility of Apc-mutant rats with a colitis-associated colon carcinogenesis model for chemoprevention studies.
Eur J Cancer Prev. 2015 May;24(3):180-7.

Irving AA, Yoshimi K, Hart ML, Parker T, Clipson L, Ford MR, Kuramoto T, Dove WF, Amos-Landgraf JM.
The utility of Apc-mutant rats in modeling human colon cancer.
Dis Model Mech. 7(11):1215-1225, 2014.

Tanaka T, Shimizu M, Kochi T, Shirakami Y, Mori T, Watanabe N, Naiki T, Moriwaki H, Yoshimi K, Serikawa T, Kuramoto T.
Apc-Mutant Kyoto Apc Delta (KAD) Rats Are Susceptible to 4-NQO-Induced Tongue Carcinogenesis.
Cancers. 2014 Jul 21;6(3):1522-39.

Yoshimi K, Tanaka T, Serikawa T, Kuramoto T.
Tumor Suppressor APC Protein Is Essential in Mucosal Repair from Colonic Inflammation through Angiogenesis.
Am J Pathol. 2013 Apr;182(4):1263-74.

Yoshimi K, Hashimoto T, Niwa Y, Hata K, Serikawa T, Tanaka T, Kuramoto T.
Use of a chemically induced-colon carcinogenesis-prone Apc-mutant rat in a chemotherapeutic bioassay.
BMC Cancer. 2012 Oct 3;12(1):448.

Yoshimi K, Tanaka T, Takizawa A, Kato M, Hirabayashi M, Mashimo T, Serikawa T, Kuramoto T.
Enhanced colitis-associated colon carcinogenesis in a novel Apc mutant rat.
Cancer Sci. 2009 Nov;100(11):2022-7.

吉見一人、真下知士、滝澤明子、加藤めぐみ、平林真澄、芹川忠夫、庫本高志
Kyoto Apc Deltaラットを用いた大腸腫瘍誘発試験
関西実験動物研究会第100回記念大会 2008.12.5