Strain information

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NBRP Rat No: 0456

Strain name: F344-Scn1a^m2Kyo

Commmon Name: F344/NSlc-Scn1a^Kyo631

Rat Genome Database

Principal Investigator:

Tadao SerikawaGraduate School of Medicine, Kyoto University

Preservation Status:

Embryo Sperm Living Animals

Coat Color

albino (c)

Inbred Generations

N8 (May 2009)

../images/Photos/F344_ScnlaKyo631_homo/1951a1024.jpg

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Usage Restrictions

The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.

Genetic Status

Inbred Segregating Congenic Consomic Recombinant Coisogenic Spont. Mutant Transgene Ind. Mutant Category Other

Comercial Availability

Research Category

Diabetes Obesity Neurobiology Ophthalmology Dentistry Cardio Hypertension Cancer Metabolism Otorhinology Immunology Infectious Osteosis Internal Organ Dermatology Reproduction Development Behavior Hematology Urology Pharmacology Research Area Others

Control Strain Marker Strain

Gene Affected

Scn1a: sodium channel, voltage-gated, type I, alpha

Origin

This strain was established by ENU mutagenesis (gene-driven). This strain possesses a point mutation in the Scn1a gene (E539A) (Mashimo, 2010). (Jun 4, 2010)

Strain characteristics

A point mutation in Scn1a gene. Please refer to F344-Scn1a^m2Kyo (NBRP No.0455). (Jun 4, 2010)

Breeding Conditions

Good breeding performance.

Genotyping

Genotyping protocol forScn1a^m2Kyo

References

A missense mutation of the gene encoding voltage-dependent sodium channel (Nav1.1) confers susceptibility to febrile seizures in rats.
Mashimo T, Ohmori I, Ouchida M, Ohno Y, Tsurumi T, Miki T, Wakamori M, Ishihara S, Yoshida T, Takizawa A, Kato M, Hirabayashi M, Sasa M, Mori Y, Serikawa T.
J Neurosci. 2010 Apr 21;30(16):5744-53.

Additional strain information (Japanese only)