Japanese
 NBRP Rat No: 0456 Strain Name: F344-Scn1am2Kyo Commmon Name: F344/NSlc-<i>Scn1a<sup>Kyo631</sup></i>
 Principal Investigator  Tadao Serikawa
 Organization   Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
 Address  Yoshidakonoe-cho, Sakyo-ku

606-8501 Kyoto

  JAPAN
 Telephone  075-753-4360  Fax:  075-753-4409  serikawa@anim.med.kyoto-u.ac.jp
 Inbred Generations   N8 (May 2009) 
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions   The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.  
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Scn1a: sodium channel, voltage-gated, type I, alpha
 Origin This strain was established by ENU mutagenesis (gene-driven). This strain possesses a point mutation in the <i>Scn1a</i> gene (E539A) (Mashimo, 2010). (Jun 4, 2010) 
 Strain Characteristics A point mutation in <i>Scn1a</i> gene. Please refer to F344-<i>Scn1a<sup>m2Kyo</sup></i> (NBRP No.0455). (Jun 4, 2010) 
 Breeding Conditions Good breeding performance. 
 Genotyping <a href="http://www.anim.med.kyoto-u.ac.jp/nbr/documents/PCR_Gene/Scn1a_m2kyo_en.pdf">Genotyping protocol for<i>Scn1a<sup>m2Kyo</i></sup></a> 
 References  A missense mutation of the gene encoding voltage-dependent sodium channel (Nav1.1) confers susceptibility to febrile seizures in rats.
Mashimo T, Ohmori I, Ouchida M, Ohno Y, Tsurumi T, Miki T, Wakamori M, Ishihara S, Yoshida T, Takizawa A, Kato M, Hirabayashi M, Sasa M, Mori Y, Serikawa T.
J Neurosci. 2010 Apr 21;30(16):5744-53.