Strain information

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NBRP Rat No: 0446

Strain name: SHR.Cg-Lepr^cp/NDmcr

Commmon Name:

Rat Genome Database

Principal Investigator:

Yukio Yamori Disease Model Cooperative Research Association

Preservation Status:

Embryo Sperm Living Animals

Coat Color

Inbred Generations

Usage Restrictions

The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The users must join a disease model cooperative research association, and obey various regulations stipulated in the rules of the association. They must also comply with the decisions made by the board of directors.

Genetic Status

Inbred Segregating Congenic Consomic Recombinant Coisogenic Spont. Mutant Transgene Ind. Mutant Category Other

Comercial Availability

Research Category

Diabetes Obesity Neurobiology Ophthalmology Dentistry Cardio Hypertension Cancer Metabolism Otorhinology Immunology Infectious Osteosis Internal Organ Dermatology Reproduction Development Behavior Hematology Urology Pharmacology Research Area Others

Control Strain Marker Strain

Gene Affected

Lepr: leptin receptor

Origin

Nonsense mutation of leptin receptor gene in the obese spontaneously hypertensive Koletsky rat was transferred to SHR/N strain at NIH. This strain has been maintained at Disease Model Cooperative Research Association (DMCRA) scince 1999. (Sep 24, 2009)

Strain characteristics

obesity, hypertension and diabetes

Breeding Conditions

Maintained by crossing heterozygotes of the fa^k/fa^k locus.

Genotyping

References

Takaya K, Ogawa Y, Hiraoka J, Hosoda K, Yamori Y, Nakao K, Koletsky RJ.
Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat.
Nat Genet. 1996 Oct;14(2):130-1

Additional strain information (Japanese only)