Japanese
 NBRP Rat No: 0446 Strain Name: SHR.Cg-Leprcp/NDmcr Commmon Name: 
 Principal Investigator  Yukio Yamori
 Organization   Disease Model Cooperative Research Association 
 Address  Seisan Kaihatsukagakukenkyujyo 3F-Simogamo Morimotocho15-Sakyoku

606-0805 Kyoto

  Japan
 Telephone  075-744-0071  Fax:  075-744-0071  dmcra@j.email.ne.jp
 Inbred Generations   ? 
   
 Coat Color
 Deposition Status
 
 
  Embryo      Sperm      Live Animals
 Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The users must join a disease model cooperative research association, and obey various regulations stipulated in the rules of the association. They must also comply with the decisions made by the board of directors.  
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Lepr: leptin receptor
 Origin Nonsense mutation of leptin receptor gene in the obese spontaneously hypertensive Koletsky rat was transferred to SHR/N strain at NIH. This strain has been maintained at Disease Model Cooperative Research Association (DMCRA) scince 1999. (Sep 24, 2009) 
 Strain Characteristics obesity, hypertension and diabetes 
 Breeding Conditions Maintained by crossing heterozygotes of the <i>fa<sup>k</sup></i>/<i>fa<sup>k</sup></i> locus. 
 Genotyping  
 References  Takaya K, Ogawa Y, Hiraoka J, Hosoda K, Yamori Y, Nakao K, Koletsky RJ.
Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat.
Nat Genet. 1996 Oct;14(2):130-1