Japanese
NBRP Rat No: 0447
Strain Name
:
SHRSP.Z-
Lepr
fa
/IzmDmcr
Commmon Name: SHRSP fatty, SHRSP.ZF
Principal Investigator
Yukio Yamori
Organization
Disease Model Cooperative Research Association
Address
Seisan Kaihatsukagakukenkyujyo 3F-Simogamo Morimotocho15-Sakyoku
606-0805 Kyoto
Japan
Telephone
075-744-0071
Fax: 075-744-0071
dmcra@j.email.ne.jp
Inbred Generations
Coat Color
Deposition Status
Embryo
Sperm
Live Animals
Usage Restrictions
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The users must join a disease model cooperative research association, and obey various regulations stipulated in the rules of the association. They must also comply with the decisions made by the board of directors.
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Others
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio- Hypertension
Oncology
Metabolism
Otorhinology
Immunology
Infectious Disease
Osteology
Internal Medicine
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Others
Control Strains
Reporter gene Strains
Gene
Lepr: leptin receptor
Origin
The <i>Lepr<sup>fa</sup></i> allele was backcrossed from ZF strain onto SHRSP/Izm by 12 backcrossing. (Sep 14, 2009)
Strain Characteristics
obesity, hypertension, diabetes and cerebrovascular disorder (Sep 14, 2009)
Breeding Conditions
Maintained by crossing heterozygotes of the <i>fa</i>/<i>fa</i> locus.
Genotyping
References
Hiraoka-Yamamoto J, Nara Y, Yasui N, Onobayashi Y, Tsuchikura S, Ikeda K.
Establishment of a new animal model of metabolic syndrome: SHRSP fatty (fa/fa) rats.
Clin Exp Pharmacol Physiol. 2004 Jan-Feb;31(1-2):107-9.