Japanese
 NBRP Rat No: 0471 Strain Name: F344-Hrkrh/Kyo Commmon Name: F344-<i>krh</i>/Kyo, Hairless Kyoto, Hanako
 Principal Investigator  Tomoji Mashimo
 Organization    The University of Tokyo, The Institute of Medical Science Laboratory Animal Research Center
 Address  4-6-1 Shirokanedai-Minatoku-Tokyoto

108-8639 

  Japan
 Telephone  03-6409-2489  Fax:    mashimo@ims.u-tokyo.ac.jp
 Inbred Generations    
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.  
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Hr: hairless
 Origin A mutant rat showing abnormal skin phenotype was found in the G1 rats produced by ENU mutagenesis (phenotype-driven) using F344/Nslc. Also called Kyoto rhino rat (krh). 
 Strain Characteristics Coat hair start fall at 4-5 weeks of age and completely fall out by 8 weeks of age. <i>krh</i> rats develop wrinkled skin, cystic hair canals and long curved nails by 4 months of age. Genetic analysis revealed a nonsense mutation in the hairless gene <i>Hr</i> on chromosome 15. <i>krh</i> rats also develop focal glomerulosclerosis (FGS) and proteinuria. (Kuramoto, 2010) (Oct 4, 2010) 
 Breeding Conditions Male rats show good breeding performance. Females are fertile, but have poor breeding performance. Maintained in heterozygous condition by backcrossing onto F344/NSlc. 
 Genotyping Determined by phenotype.
<a href="http://www.anim.med.kyoto-u.ac.jp/nbr/documents/PCR_Gene/Hr_khr_en.pdf">Genotyping protocol for Hr</a> 
 References  Yoshimasu T, Kuramoto T, Kaminaka C, Kanazawa N, Yamamoto Y, Furukawa F.
Efficacy of 0.1% adapalene in a non-inflammatory Kyoto Rhino Rat acne model.
J Dermatol Sci. 76(2):143-8, 2014.

Kuramoto T, Kuwamura M, Tagami F, Mashimo T, Nose M, Serikawa T.
Kyoto rhino rats derived by ENU mutagenesis undergo congenital hair loss and exhibit focal glomerulosclerosis.
Exp Anim. 60(1):57-63, 2011.