Origin |
Ikeda developed transgenic rats carrying the human growth hormone (Gh1) driven by murine Wap promoter, originated from Wistar-Imamichi (Ikeda, 1994). After that this transgenic strain has been maintained by artificial insemination to wild-type Wistar-Imamichi. Two lines of this transgenic strain were established named Line 1: characterized by relatively high level of serum Gh1 (high line, NBRPNo.0490), and Line 2: relatively low level of serum Gh1 (low line, NBRPNo.0491). (Oct 30, 2009) |
References |
Ikeda A, Matsuyama S, Nishihara M, Tojo H, Takahashi M. Changes in endogenous growth hormone secretion and onset of puberty in transgenic rats expressing human growth hormone gene. Endocr J. 41(5):523-9, 1994.
Ikeda A, Matsumoto Y, Chang KT, Nakano T, Matsuyama S, Yamanouchi K, Ohta A, Nishihara M, Tojo H, Sasaki F, Takahashi M. Different female reproductive phenotypes determined by human growth hormone (hGH) levels in hGH-transgenic rats. Biol Reprod. 56(4):847-51, 1997.
Cho Y, Ariga M, Uchijima Y, Kimura K, Rho JY, Furuhata Y, Hakuno F, Yamanouchi K, Nishihara M, Takahashi S. The novel roles of liver for compensation of insulin resistance in human growth hormone transgenic rats. Endocrinology. 147(11):5374-84, 2006. |