Japanese
 NBRP Rat No: 0051 Strain Name: LEC/Tj Commmon Name: 
 Principal Investigator  Kozo Matsumoto
 Organization   The University of Tokushima Graduate School of Medicine Institute of Health Biosciences, Division of Animal Research Resources
 Address  3-18-15 Kuramoto-cho

770-8503 Tokushima

  JAPAN
 Telephone  088-633-9278  Fax:  088-600-9429  kozo@anex.med.tokushima-u.ac.jp
 Inbred Generations   F45+55 
   
 Coat Color
 Deposition Status
 
 cinnamon-like (A,B,C,D,r)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Atp7b: ATPase, Cu++ transporting, beta polypeptide, Ptprk: protein tyrosine phosphatase, receptor type, K
 Origin Found in Long Evans strain at Kobe University > Inbreeding at Hokkaido University > Otsuka Pharmaceutical Co. > The University of Tokushima 1989 
 Strain Characteristics Hepatitis, jaundice, and a defect of T cell maturation. 
 Breeding Conditions Good breeding performance. Sib mating. 
 Genotyping  
 References  Nakajima M, Kato J, Kohgo Y, Takeichi N, Niitsu T. Point mutation of aldehyde dehydrogenase-2 gene in mutant strains of Long-Evans rats. Alcohol Alcohol 29 Suppl 1:39-43, 1994

Kose H, Sakai T, Tsukumo S, Wei K, Yamada T, Yasutomo K, Matsumoto K.
Maturational arrest of thymocyte development is caused by a deletion in the receptor-like protein tyrosine phosphatase kappa gene in LEC rats.
Genomics. 2007 Jun;89(6):673-7.

Yoshihara M, Sato T, Saito D, Ohara O, Kuramoto T, Suyama M.
Application of target capture sequencing of exons and conserved non-coding sequences to 20 inbred rat strains.
Genomics Data. 2016 Dec; 10: 155-157