Japanese
 NBRP Rat No: Strain Name: EXHC/Ta Commmon Name: ExHC/Ta, Exogenously hypercholesterolemic rat
 Principal Investigator  Yuji Iizawa
 Organization   Takeda Chemical Industries, Ltd.  
 Address   2-17-85, jusohonmati, yodogawa-ku

532－8686 Osaka

  Japan
 Telephone  06-6300-6868  Fax:  06-6300-6207  Izawa_yuji@takeda.co.jp
 Inbred Generations   F116 (Mar 2008) 
   
 Coat Color
 Deposition Status
 
 albino(c)
  Embryo      Sperm      Live Animals
 Usage Restrictions   "USER" shall not utilize "THE RESOUCE (ExHC/Ta)" for research The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
aimed at discovering or validating drug candidates.
Should the results obtained from the use of "THE RESOURCE (ExHC/Ta)" be published or presented at meeting or symposia, "USER" shall send the manuscript to "DEPOSITOR" prior to submitting it for publication or presentation. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin EXHC rats were established from JcL:SD by repetitive inbreeding, in that a rat showing a higher serum total cholesterol was selected when fed 1% cholesterol-containing diet (Imai, 1973). (Jul 15, 2010) 
 Strain Characteristics EXHC rats develop hypercholesterolemia for exogenous cholesterol without hypertriglyceridemia. (Imai, 1973; Imaizumi, 1992)<br />
Significant QTLs for serum total cholesterol levels were mapped on rat chromosome 5 and 14 (<i>Dihc1</i> and <i>Dich2</i>, respectively) (Asahina, 2005). <i>SMEK2</i> was identified as a candidate gene for <i>Dich2</i> (Asahina, 2009). <br />
Fed a high cholesterol diet, EXHC rats develop proteinuria and characteristic glomerular lesion (Hattori, 1993; Miyazaki, 1997). (Jul 15, 2010) 
 Breeding Conditions  
 Genotyping  
 References  Imai Y, Matsumura H.
Genetic studies on induced and spontaneous hypercholesterolemia in rats.
Atherosclerosis. 1973 Jul-Aug;18(1):59-64.

Imaizumi K, Nagatomi A, Sato M, Tominaga A, Sugano M.
Cholesterol metabolism in ExHC (exogenous hypercholesterolemic) rats.
Biochim Biophys Acta. 1992 Jan 3;1123(1):101-9.

Asahina M, Sato M, Imaizumi K.
Genetic analysis of diet-induced hypercholesterolemia in exogenously hypercholesterolemic rats.
J Lipid Res. 2005 Oct;46(10):2289-94.

Asahina M, Haruyama W, Ichida Y, Sakamoto M, Sato M, Imaizumi K.
Identification of SMEK2 as a candidate gene for regulation of responsiveness to dietary cholesterol in rats.
J Lipid Res. 2009 Jan;50(1):41-6.

Hattori M, Yamaguchi Y, Kawaguchi H, Ito K.
Characteristic glomerular lesions in the ExHC rat: a unique model for lipid-induced glomerular injury.
Nephron. 1993;63(3):314-22.

Miyazaki K, Isbel NM, Lan HY, Hattori M, Ito K, Bacher M, Bucala R, Atkins RC, Nikolic-Paterson DJ.
Up-regulation of macrophage colony-stimulating factor (M-CSF) and migration inhibitory factor (MIF) expression and monocyte recruitment during lipid-induced glomerular injury in the exogenous hypercholesterolaemic (ExHC) rat.
Clin Exp Immunol. 1997 May;108(2):318-23.