Origin |
F344 rats are susceptible and ACI rats are resistant to PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine)-induced ACF (aberrant crypt foci) formation (Nagao, 1998). This congenic strain was established by backcrossing ACI.F344-(<i>D16Rat12-D16Mco2</i>) onto ACI/N, followed by intercrossing in N9 generation, thereafter maintained by crossing homozygous individuals. (Jul 7, 2009) |