Strain information

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NBRP Rat No: 0558

Strain name: ACI.F344-(D16Mit5-D16Nkg27)/Nkg

Commmon Name:

Rat Genome Database

Principal Investigator:

Hitoshi NakagamaNational Cancer center

Preservation Status:

Embryo Sperm Living Animals

Coat Color

agouti

Inbred Generations

F3 (Nov 2008)

Usage Restrictions

In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.

Genetic Status

Inbred Segregating Congenic Consomic Recombinant Coisogenic Spont. Mutant Transgene Ind. Mutant Category Other

Comercial Availability

Research Category

Diabetes Obesity Neurobiology Ophthalmology Dentistry Cardio Hypertension Cancer Metabolism Otorhinology Immunology Infectious Osteosis Internal Organ Dermatology Reproduction Development Behavior Hematology Urology Pharmacology Research Area Others

Control Strain Marker Strain

Gene Affected

Origin

F344 rats are susceptible and ACI rats are resistant to PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine)-induced ACF (aberrant crypt foci) formation (Nagao, 1998). This congenic strain was established by backcrossing ACI.F344-(D16Rat12-D16Mco2) onto ACI/N, followed by intercrossing in N6 generation, thereafter maintained by crossing homozygous individuals. (Jul 7, 2009)

Strain characteristics

ACF formation induced by feeding 2-weeks PhIP-containing diet and 4-weeks high-fat diet is higher in this congenic strain than that in ACI/N strain. (Jul 7, 2009)

Breeding Conditions

Genotyping

Determined by PCR-SSLP method. About D16Nkg27, please refer to http://www.ncc.go.jp/en/nccri/divisions/02bioc/02bioc01_3_1.html.

References

Additional strain information (Japanese only)