Japanese
NBRP Rat No: 0531
Strain Name
:
BN.LEC-(
D4Rat128-D4Rat106
)/Hkv
Commmon Name: B3
Principal Investigator
Takashi Agui
Organization
Graduate School of Veterinary Medicine Experimental Animal Sciences
Address
Nishi 9 Kita 18 jou Kita-ku, Sapporo
060-0818 Hokkaido
Japan
Telephone
011-706-5106
Fax: 011-706-5106
agui@vetmed.hokudai.ac.jp
Inbred Generations
N6F14
Coat Color
Deposition Status
non-agouti brown
Embryo
Sperm
Live Animals
Usage Restrictions
An article is in progress. Users should be required an approval form from dipositor.
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Others
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio- Hypertension
Oncology
Metabolism
Otorhinology
Immunology
Infectious Disease
Osteology
Internal Medicine
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Others
Control Strains
Reporter gene Strains
Gene
Origin
The genetic region between D4Rat128 and D4Rat106 of LEC/Ncu was introgressed to BN/Ncu using “speed congenic” method to establish the congenic strain. One QTL which showed very strong linkage to the X-ray hypersensitivity of LEC rats was mapped on chromosome 4 (Agui, 2000). (Jul 15, 2010)
Strain Characteristics
The congenic rats don't have the X-ray sensitivity that of LEC rats. (Jul 15, 2010)
Breeding Conditions
Sib mating.
Genotyping
References
Agui T, Miyamoto T, Jung CG, Tsumagari T, Masuda K, Manabe T.
Genetic linkage analysis of X-ray hypersensitivity in the LEC mutant rat.
Mamm Genome. 11(10):862-5, 2000.