Japanese
 NBRP Rat No: 0548 Strain Name: BCR/Nn Commmon Name: DR150-2
 Principal Investigator  Nobuyuki Nukina
 Organization   RIKEN Brain Science Institute(RIKEN BSI) Laboratory for Structural Neuropathology
 Address  2-1 Hirosawa Wako-city, Saitama

351-0198  Saitama

  Japan
 Telephone  048-462-1111　内線7644  Fax:  048-462-4796  nukina@brain.riken.jp
 Inbred Generations   F22 (Aug 2008) 
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin In the course of producing transgenic rats (DRPLA promoter + huntingtin exon1+EGFP on a Slc:SD background), a mutant rat showing involuntary movements (circling) and symptoms of dystonia was found in F6 progeny. Subsequent by the selection of the involuntary movement segregated the transgene from the phenotype. Thereafter this strain was maintained by only the phenotype (not the transgene). (Jul 7, 2009) 
 Strain Characteristics Involuntary movements and symptoms of dystonia appear after 4 weeks of age. These phenotypes have little effect on life span. (Jul 7, 2009) 
 Breeding Conditions This strain is maintained by crossing heterozygous females (without involuntary movement) with homozygous males (with involuntary movement). Homozygous females have less performance of nursing behavior for their pups. Homozygous males are fertile until about 25 weeks of age. Sib mating. (Jul 7, 2009) 
 Genotyping Determined by phenotype. (Jul 7, 2009) 
 References