Origin
The spontaneously hypertensive rat (SHR) was established by selective breeding of outbred Wistar-Kyoto rats which showing hypertension by Prof. Okamoto at Department of Pathology, Kyoto University School of Medicine in 1963 (Okamoto, 1963). To Institute of Laboratory Animals Graduate School of Medicine, Kyoto University in 1975. (Jun 1, 2010)
Strain characteristics
Hypertension. Control strain is WKY.
Breeding Conditions
Good breeding performance. Sib mating.
References
McDermott-Roe C, Ye J, Ahmed R, Sun XM, Serafín A, Ware J, Bottolo L, Muckett P, Cañas X, Zhang J, Rowe GC, Buchan R, Lu H, Braithwaite A, Mancini M, Hauton D, Martí R, García-Arumí E, Hubner N, Jacob H, Serikawa T, Zidek V, Papousek F, Kolar F, Cardona M, Ruiz-Meana M, García-Dorado D, Comella JX, Felkin LE, Barton PJ, Arany Z, Pravenec M, Petretto E, Sanchis D, Cook SA.
Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function.
Nature. 2011 Oct 5;478(7367):114-8
Okamoto K, Aoki K.
Development of a strain of spontaneously hypertensive rats.
Jpn Circ J. 1963 Mar;27:282-93.