Japanese
 NBRP Rat No: 0013 Strain NameSHR/Kyo Commmon Name: Spontaneously Hypertensive Rat
 Principal Investigator  Tadao Serikawa
 Organization   Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
 Address  Yoshidakonoe-cho, Sakyo-ku

606-8501 Kyoto

 JAPAN
 Telephone  075-753-4360  Fax:  075-753-4409  serikawa@anim.med.kyoto-u.ac.jp
 Inbred Generations   F97 (April 2012) 
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin The spontaneously hypertensive rat (SHR) was established by selective breeding of outbred Wistar-Kyoto rats which showing hypertension by Prof. Okamoto at Department of Pathology, Kyoto University School of Medicine in 1963 (Okamoto, 1963). To Institute of Laboratory Animals Graduate School of Medicine, Kyoto University in 1975. (Jun 1, 2010) 
 Strain Characteristics Hypertension. Control strain is WKY. 
 Breeding Conditions Good breeding performance. Sib mating. 
 Genotyping  
 References  McDermott-Roe C, Ye J, Ahmed R, Sun XM, Serafín A, Ware J, Bottolo L, Muckett P, Cañas X, Zhang J, Rowe GC, Buchan R, Lu H, Braithwaite A, Mancini M, Hauton D, Martí R, García-Arumí E, Hubner N, Jacob H, Serikawa T, Zidek V, Papousek F, Kolar F, Cardona M, Ruiz-Meana M, García-Dorado D, Comella JX, Felkin LE, Barton PJ, Arany Z, Pravenec M, Petretto E, Sanchis D, Cook SA.
Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function.
Nature. 2011 Oct 5;478(7367):114-8

Okamoto K, Aoki K.
Development of a strain of spontaneously hypertensive rats.
Jpn Circ J. 1963 Mar;27:282-93.