Japanese
 NBRP Rat No: 0570 Strain Name: KFRS3A/Kyo Commmon Name: SRR03-mink,Pearl
 Principal Investigator  Takashi Kuramoto
 Organization   Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
 Address  Yoshidakonoe-cho, Sakyo-ku

606-8501 Kyoto

  Japan
 Telephone  075-753-4494  Fax:  075-753-4409  kuramot@anim.med.kyoto-u.ac.jp
 Inbred Generations    
   
 Coat Color
 Deposition Status
 
 mink, Pearl
  Embryo      Sperm      Live Animals
 Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin One male rat "SRR-Rocket Science" was introduced from American fancy rat colony (Spoiled Ratten Rattery: SRR, in Kansas City, Missouri) to Kyoto University on July 13, 2005. Inbreeding started from F1 progeny of male "SRR-Rocket Science" and a female PVG/Seac. Homozygous rats for mink were selected for inbreeding. (Sep 25, 2009) 
 Strain Characteristics This strain has two mutations, American mink (<i>am</i>) which causes light brown body hair and Pearl (<i>Pel</i>) which causes lighter coat color and is lethal in the embryonic period if homozygous. Genetic analyses mapped <i>am</i> to Chr 1 (Kuramoto, 2010). A SINE insertion was identified in the exon 7 of Hermansky-Pudlak syndrome 5 (Hps5)gene (Kuramoto, 2010). (Jul 4, 2011) 
 Breeding Conditions Maintained by crossing of heterozygous and wild-type for Pearl mutation. This strain is heterozygous for Pearl mutation (segregating strain) and homozygous for mink mutation. Good breeding performance. (Sep 25, 2009) 
 Genotyping  
 References  Kuramoto T, Yokoe M, Yagasaki K, Kawaguchi T, Kumafuji K, Serikawa T.
Genetic analyses of fancy rat-derived mutations.
Exp Anim. 2010;59(2):147-55.

Takashi Kuramoto, Satoshi Nakanishi, Ken-ichi Yamasaki, Kenta Kumafuji, Yuichi Sakakibara, Yuki Neoda, Akiko Takizawa, Takehito Kaneko, Mito Otsuki, Ryoko Hashimoto, Birger Voigt, Tomoji Mashimo and Tadao Serikawa
Genetic Quality Control of the Rat Strains at the National Bio Resource Project-Rat.
ibc.2010 Volume 2 Article no. 0012