Japanese
 NBRP Rat No: 0572 Strain Name: KFRS4/Kyo Commmon Name: SRR04
 Principal Investigator  Takashi Kuramoto
 Organization   Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
 Address  Yoshidakonoe-cho, Sakyo-ku

606-8501 Kyoto

  Japan
 Telephone  075-753-4494  Fax:  075-753-4409  kuramot@anim.med.kyoto-u.ac.jp
 Inbred Generations   F24 (April 2012) 
   
 Coat Color
 Deposition Status
 
 light brown
  Embryo      Sperm      Live Animals
 Usage Restrictions   The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin One male rat "TSR Louis" was introduced from American fancy rat colony (Spoiled Ratten Rattery: SRR, in Kansas City, Missouri) to Kyoto University on July 13, 2005. Inbreeding started from F1 progeny of male "TSR Louis" and a female PVG/Seac. (Sep 25, 2009) 
 Strain Characteristics This strain carries two mutations, head spot (<i>hs</i>) which causes white spotting on the head, and dumbo (<i>dmbo</i>) which causes abnormal ear morphology (Kuramoto, 2010). Ears are set lower on the head, and are larger and rounder. Genetic analyses mapped <i>hs</i> to Chr 15 and <i>dmbo</i> to Chr 14. A SINE insertion was identified in the exon 7 of Hermansky-Pudlak syndrome 5 (Hps5)gene (Kuramoto, 2010). (Jul 4, 2011) 
 Breeding Conditions Good breeding performance. (Sep 25, 2009) 
 Genotyping  
 References  Yoshihara M, Sato T, Saito D, Ohara O, Kuramoto T, Suyama M.
A deletion in the intergenic region upstream of Ednrb causes head spot in the rat strain KFRS4/Kyo.
BMC Genet. 2017 Mar 29;18(1):29.

Yoshihara M, Saito D, Sato T, Ohara O, Kuramoto T, Suyama M.
Design and application of a target capture sequencing of exons and conserved non-coding sequences for the rat.
BMC Genomics. 2016 Aug 9;17:593.

Kuramoto T, Yokoe M, Tanaka D, Yuri A, Nishitani A, Higuchi Y, Yoshimi K, Tanaka M, Kuwamura M, Hiai H, Kabashima K, Serikawa T.
Atopic dermatitis-like skin lesions with IgE hyperproduction and pruritus in KFRS4/Kyo rats.
J Dermatol Sci. 2015 Nov;80(2):116-23.


Quina L, Kuramoto T, Luquetti DV, Cox TC, Serikawa T, Turner EE.
Deletion of a conserved regulatory element required for Hmx1 expression in craniofacial mesenchyme in the dumbo rat: a novel cause of congenital ear malformation.
Dis Model Mech. 2012 Nov;5(6):812-22.

Watanabe K, Wada K, Ohashi T, Okubo S, Takekuma K, Hashizume R, Hayashi J, Serikawa T, Kuramoto T, Kikkawa Y.
A 5-bp Insertion in Mip Causes Recessive Congenital Cataract in KFRS4/Kyo Rats.
PLoS One, 2012, 7 (11), e50737.

Kuramoto T, Yokoe M, Yagasaki K, Kawaguchi T, Kumafuji K, Serikawa T.
Genetic analyses of fancy rat-derived mutations.
Exp Anim. 2010;59(2):147-55.

Takashi Kuramoto, Satoshi Nakanishi, Ken-ichi Yamasaki, Kenta Kumafuji, Yuichi Sakakibara, Yuki Neoda, Akiko Takizawa, Takehito Kaneko, Mito Otsuki, Ryoko Hashimoto, Birger Voigt, Tomoji Mashimo and Tadao Serikawa
Genetic Quality Control of the Rat Strains at the National Bio Resource Project-Rat.
ibc.2010 Volume 2 Article no. 0012