Japanese
 NBRP Rat No: 0573 Strain Name: KFRS5A/Kyo Commmon Name: SRR05-Rex
 Principal Investigator  Takashi Kuramoto
 Organization   Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
 Address  Yoshidakonoe-cho, Sakyo-ku

606-8501 Kyoto

  Japan
 Telephone  075-753-4494  Fax:  075-753-4409  kuramot@anim.med.kyoto-u.ac.jp
 Inbred Generations    
   
 Coat Color
 Deposition Status
 
 black hooded
  Embryo      Sperm      Live Animals
 Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin One male rat "SRR Coming Home" was introduced from American fancy rat colony (Spoiled Ratten Rattery: SRR, in Kansas City, Missouri) to Kyoto University on July 13, 2005. Inbreeding started from F1 progeny of male "SRR Coming Home" and a female TM/Kyo. (Sep 25, 2009) 
 Strain Characteristics The rat autosomal dominant Rex (<i>Re</i>) mutation on chromosome 7 causes curly hair in <i>Re</i>/+ and hair loss in <i>Re</i>/<i>Re</i> rats. Histopathologically, the <i>Re</i>/+ rat showed dilatation of the hair follicle and hairs with irregularly-coated cuticles, and the <i>Re</i>/<i>Re</i> rat showed more severe effects. <i>Re</i> is a 7-bp deletion at the splicing acceptor site of intron 1 of the keratin 71 (<i>Krt71</i>) gene. (Kuramoto, 2010) (Apr 20, 2010) 
 Breeding Conditions Maintained by crossing of heterozygous and homozygous for Rex gene. Good breeding performance. (Sep 25, 2009) 
 Genotyping  
 References  Kuramoto T, Hirano R, Kuwamura M, Serikawa T.
Identification of the Rat Rex Mutation as a 7-Bp Deletion at Splicing Acceptor Site of the Krt71 Gene.
J Vet Med Sci. 2010 Jul;72(7):909-12.

Kuramoto T, Yokoe M, Yagasaki K, Kawaguchi T, Kumafuji K, Serikawa T.
Genetic analyses of fancy rat-derived mutations.
Exp Anim. 2010;59(2):147-55.