Japanese
NBRP Rat No: 0612
Strain Name
:
WKY/Kiha
Commmon Name: HA-WKY
Principal Investigator
Hiroyuki Ito
Organization
Kinki University Faculty of Medicine
Address
377-2, Ohnohigashi, Oosaka-sayama-shi
589-8511 Osaka
Japan
Telephone
072-366-0221 (x3142)
Fax: 072-360-2028
takao@med.kindai.ac.jp
Inbred Generations
F32 (Apr 2010)
Coat Color
Deposition Status
albino (c)
Embryo
Sperm
Live Animals
Usage Restrictions
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Others
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio- Hypertension
Oncology
Metabolism
Otorhinology
Immunology
Infectious Disease
Osteology
Internal Medicine
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Others
Control Strains
Reporter gene Strains
Gene
Origin
In 1974, WKY strain was transferred Dr. Okamoto from Kyoto University to. In Department of Pathology, Kinki University School of Medicine, a rat showing higher serum adiponectin concentration was found (Inoue, 2010). (Aug 31, 2010)
Strain Characteristics
WKY/Kiha (HA-WKY) rats exhibit about 4-fold higher serum adiponectin concentration at 6 weeks of age compared with that of WKY/Izm. When fed high-fat diets, WKY/Kiha rats show hyperinsulinemia and severe hypercholesterolemia. The lack of adiponectin binding to skeletal muscle seems to cause these phenotypes of WKY/Kiha (Inoue, 2010). (Aug 31, 2010)
Breeding Conditions
Sib mating.
Genotyping
No data.
References
Inoue T, Takemori K, Yamamoto K, Ito H.
Characterization of Wistar-Kyoto rats showing hyperadiponectinemia.
Life Sci. 2010 Feb 27;86(9-10):344-50.