Japanese
 NBRP Rat No: 0599 Strain Name: SD-Tg(Eno2-ATXN3*64Q)29Kakiz Commmon Name: NSE-Q64C(L29)
 Principal Investigator  Akira Kakizuka (Hori Seiji)
 Organization   Graduate School of BIOSTUDIES, Kyoto University Department of Functional Biology
 Address  Yoshidakonoe-cho, Sakyo-ku, Kyoto

606-8501 Kyoto

  Japan
 Telephone  075-753-7677  Fax:  075-753-7676  shori@lif.kyoto-u.ac.jp
 Inbred Generations   10 (Oct 2009) 
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions  The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent indicating the extent of experimental use of it from the DEPOSITOR. For a commercial use of this resource, a new contract must be concluded between the DEPOSITOR and the RECIPIENT.  
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Eno2: enolase 2, gamma, neuronal; ATXN3: ataxin 3
 Origin Background strain is Slc:SD. Please refer to SD-Tg(Eno2-ATXN3*64Q)16Kakiz (NBRP No.0598). (Jun 22, 2010) 
 Strain Characteristics This transgenic strain contains human <i>ATXN3</i> (<i>MJD1</i>, polyQ repeat 64) gene fragment driven by rat <i>Eno2</i> (NSE: neuron specific enolase) promoter. Transgene ATXN3*64Q is the construct containing of C-terminal part and polyglutamine part of human <i>ATXN3</i>, but not of N-terminal part. Aggregation of ATXN3*64Q polygultamine leads to ataxia. Line 16 is more likely to develop ataxia than Line 29. (Jun 22, 2010) 
 Breeding Conditions Maintained by crossing between Tg hemizygous and wild rats. (Jun 22, 2010) 
 Genotyping Genotyping by PCR analysis. 
 References  in preparation