Japanese
 NBRP Rat No: 0635 Strain Name: SD-Tg(Pbsn-TAg)1Obs Commmon Name: SV40ラット、TRAPラット
 Principal Investigator  Tomoyuki Shirai
 Organization   Nagoya City University Graduate School of Medical Sciences Department of Experimental Pathology
 Address  

467-8601  Nagoya

  Japan
 Telephone  052-853-8156  Fax:  052-842-0817  sattak@med.nagoya-cu.ac.jp
 Inbred Generations    
   
 Coat Color
 Deposition Status
 
 albino
  Embryo      Sperm      Live Animals
 Usage Restrictions  In publishing, a citation of the following literature(s) designated by the DEPOSITOR is requested. (see references) 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene ・SV40 Large T Antigen領域(No.5146-2676) ・Rat probasin promoter
 Origin This transgenic strain was generated by microinjection into Jcl:SD fertilized eggs and carries SV40 Large T Antigen drived by Rat probasin promoter.
 
 Strain Characteristics This male Tg rats develop prostate cancer.
 
 Breeding Conditions Tg female ×Jcl:SD male
 
 Genotyping  
 References  1.　Asamoto, M., et al., Prostate carcinomas developing in transgenic rats with SV40 T antigen expression under probasin promoter control are strictly androgen dependent. Cancer Res, 2001. 61(12): p. 4693-700.
2.　Asamoto, M., et al., Effects of genetic background on prostate and taste bud carcinogenesis due to SV40 T antigen expression 　　　　　　　　　　　　　 under probasin gene promoter control. Carcinogenesis, 2002. 23(3): p. 463-7.
3.　Cho, Y.M., et al., Age-dependent histopathological findings in the prostate of probasin/SV40 T antigen transgenic rats: lack of influence of carcinogen or testosterone treatment. Cancer Sci, 2003. 94(2): p. 153-7.
4.　Cho, Y.M., et al., Suppressive effects of antiandrogens, finasteride and flutamide on development of prostatic lesions in a transgenic rat model. Prostate Cancer Prostatic Dis, 2007.
5.　Hokaiwado, N., et al., Lack of effect of human c-Ha-ras proto-oncogene overexpression on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats. Cancer Sci, 2003. 94(12): p. 1042-5.
6.　Kandori, H., et al., Influence of atrazine administration and reduction of calorie intake on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats. Cancer Sci, 2005. 96(4): p. 221-6.
7.　Said, M.M., et al., Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by leuprorelin, a luteinizing hormone-releasing hormone agonist. Cancer Sci, 2006. 97(6): p. 459-67.
8.　Tang, M., et al., Protective effects of citrus nobiletin and auraptene in transgenic rats developing adenocarcinoma of the prostate (TRAP) and human prostate carcinoma cells. Cancer Sci, 2007. 98(4): p. 471-7.