English
 NBRP Rat No: 0640 系統名 :    SD-Tg(Dsp-mCherry,-DTR)Jog 通称: DSP-STOP-hDTR
 研究責任者:   Jonathan flint
 所属機関名:   University of Oxford The Wellcome Trust Centre for human Genetics
  住所:   〒 OX3 7BN  

 Oxford  Roosevelt Drive

 
 電話番号:  +44 (0)1865 287772  Fax: +44 (0)1865 287501   jf@well.ox.ac.uk
 近交世代数:  More than 5 
   
 毛色:  
 保存状況:
 
 White
  胚           精子          生体
  利用条件:  利用者は、研究成果の公表にあたって謝辞の表明を必要とする。
 
 分類:   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    その他  
  コマーシャルブリーダー:   
 研究分野:   糖尿病・肥満    脳神経疾患   眼疾患    歯科疾患   循環器系疾患・高血圧
  がん・腫瘍   代謝、内分泌    耳鼻疾患   発生   感染症
   骨形態異常   消化器疾患   皮膚疾患    生殖器疾患   免疫・アレルギー疾患
   行動・学習   血液疾患   泌尿器疾患   薬理学   その他  
  対照動物   レポーター遺伝子動物  
 遺伝子: Dsp
 由来: The rats were originally generated by the University of Michigan Transgenic Animal Model Core, University of Michigan. They use a Crl:CD(SD) sub strain of Sprague-Dawley rats, obtained from Charles River Laboratory (Wilmington, MA, USA). The F1 rats have been bred in the UK with Hsd:Sprague Dawley (Harlan laboratories, UK), which are direct descendants of the original 1925 SD-company colony (Madison, Wisconsin, USA).  
 特性など: This rat carries a transgene consisting of the Dsp promoter followed by a 'STOP’ cassette flanked by FRT sites. The stop cassette consists of an mcherry gene encoding for a red fluorescent protein and a kanamycin resistant gene and three SV40polyA adenylation signals. The STOP cassette is followed by a gene encoding for the human diphtheria toxin receptor. Red fluorescence can be detected from the skin of the animals but not the brain. 
繁殖・維持方法: Both males and fertiles are fertile and generate good litter sizes of 10-15 pups.  
 遺伝診断法:  
  参考文献:  
 追加の系統情報: