NBRP Rat No: 0260 系統名 :    BB/OK 通称: 
 研究責任者:   Ingrid Kloting
 所属機関名:  University of GreifswaldLaboratory Animal Science
  住所:   〒17495 


 電話番号:  +4938348619261  Fax: +4938348619111  kloeting@uni-greifswald.de
 近交世代数:  F62 
 albino (a,b,c,h)
  胚           精子          生体
  利用条件:  利用者は、研究成果の公表にあたって謝辞の表明を必要とする。 
 分類:   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    その他  
 研究分野:   糖尿病・肥満    脳神経疾患   眼疾患    歯科疾患   循環器系疾患・高血圧
  がん・腫瘍   代謝、内分泌    耳鼻疾患   発生   感染症
   骨形態異常   消化器疾患   皮膚疾患    生殖器疾患   免疫・アレルギー疾患
   行動・学習   血液疾患   泌尿器疾患   薬理学   その他  
  対照動物   レポーター遺伝子動物  
 由来: 1983年にカナダ・オタワ州のBio Breeding Laboratoriesで飼育していた非近交系動物を、ドイツのKarlsburgに持ち込み近親交配を始めた。 
 特性など: 80-100%の雌雄ラットが、30~90日齢の間に1型糖尿病を自然発症する。 
  参考文献: Stark,O.,Kloting,I.,Reiher,K. and K.D. Kohnert
The major histocompatibility complex and insulin-dependent diabetes in BB rats. Acta biol.med. germ.41,1982,1129-1133

Kloting, I., Hubner, R. and O. Stark
Major histocompatibility complex (MHC)-independent differences between diabetes-prone BB rats and their parental Wistar rat strain in some hematologic and metabolic traits. Res. Exp. Med.182,1983,231-236

Kloting, I., O. Stark and H.J. Hahn
Animal model of the insulin-dependent diabetes mellitus in BB rats: Their RT1u homogeneity and prolonged survival of allogeneic skin grafts. Folia Biol.30,1984,24-32

Kloting, I., Stark, O. and R. Brdicka
Incidence of insulin-dependent diabetes mellitus in BB rats: Their genetic heterogeneity and susceptibility to infection. Folia Biol.30,1984,33-42

Kloting, I. and Stark, O.
Results of the local graft-versus-host reaction support the immunogenetic concept of the insulin-dependent diabetes mellitus in BB rats. Folia Biol.30,1984,202-208

Kloting, I. und K. Reiher
Einige Aspekte zur Haltung und Reproduktion spontandiabetischer BB-Ratten. Z.Versuchstierkd.27,1985,5-12

Kloting, I. and O. Stark
Occurrence of antibodies against gene products of the major histocompatibility complex in normal sera of diabetes-prone BB rats. Folia Biol.31,1985,34-37

Kloting, I. and O. Stark
Genetic studies of IDDM in BB rats: The incidence of diabetes in F2 and first backcross hybrids allows rejection of recessive hypothesis. Exp.Clin.Endocrinol.89,1987,312-318

Kloting, I., Vogt, L., Stark, O.and U. Fischer
Genetic heterogeneity in different BB rat subpopulations. Diabetes Res.6,1987,145-149

Knospe, S., Kohler, E. and I. Kloting
Cell-mediated immune reactions against islets of Langerhans in diabetes-prone BB rats. Exp.Clin.Endocrinol.89,1987,290-296

Ziegler, B., Kloting, I., Besch, W., Ziegler, M. and H.J. Hahn
Cytotoxic activity of sera from diabetic BB rats against BB rat islet-a functional study. Diabetes Res. 4,1987,67-72

Kloting, I. and L. Vogt
Breeding problems in diabetes-prone BB rats after "wet hysterectomy". Z.Versuchstierkd.31, 1988,19-22

Hehmke, B., Schröder, D. and I. Kloting
Early appearance of complement-dependent antibody-mediated cytotoxicity (C , AMC) to islet cells in serum of diabetes-prone BB/OK rats. Diabetes Res.15,1990,183-186

Vogt, L. and I. Kloting
Breeding management of BB rats by the aid of the computer program BB_RADABA. J.Exp.Anim.Sci.35,1992,34,184-188

Kloting, I. and L. Vogt
BB/O(ttawa)K (arlsburg) rats: Features of a subline of diabetes-prone BB rats.Diabetes Res., 1991,18,79-87

Dunger, A., Kloting, I., Besch, W. and H.J. Hahn
The effect of serum concentration and sources on DNA synthesis and insulin secretion of cultured islets. Exp.Clin.Endocrinol.99, 1992, 34-38

Kloting, I. and L. Vogt
On the influence of metabolic state of parents at conception and pregnancy on incidence and age at onset of diabetes in the progeny of BB/OK rats. Diabetes Res. 19,1992, 37-40

Kloting, I., Voigt B. and L. Vogt
Molecular analysis of diabetes-prone BB rat sublines and derivatives of their common ancestor as a tool to search for candidate loci causing different phenotypes in BB rats. Diabetes Res. 29, 1995, 65-71

Lucke, S., Kloting, I., Pusch, A., Heinrich, H.W. and H.J. Hahn
Endocrine pancreas histology of congenic BB-Rat strains with reduced diabetes incidence after genetic manipulation on chromosomes 4, 6 and X. Autoimmunity 36, 2003, 143-149

Hahn, H.J., Lucke, S., Kloting, I. and W. Besch
Prospective investigations of long-term normoglycaemic BB/OK-rats: Serial determination of glucose tolerance, insulitis, B-cell volume density and pancreatic insulin content. Exp.Clin.Endocrinol.98, 1991, 185-192 
 追加の系統情報:  BB