Rat Strain Information (FOB: Stimulus Response)
Strain Name  BN/1Hok 
Approach Response  2,2,2,2,2,2  
Touch Response  2,2,2,2,2,2  
Eyelid Reflex  2,2,2,2,2,2  
Pinna Reflex  2,2,2,2,2,2  
Sound Response  2,2,2,2,2,2  
Tail Pinch Response  2,2,2,2,2,2  
Pupillary Reflex  2,2,2,2,2,2  
Righting Reflex  1,1,1,1,1,1  
 

Stimulus response

1) Approach response: Slowly move the tip of a dull object (e.g., tweezers) up to 2-3 cm in front of the animal and hold there for 4 seconds. Choose the item from the following list that best describes the animal's reaction to the dull object (scored).


1: No reaction
2: Slowly approaches, sniffs and pulls back/normal
3: Twitches (muscular tenseness)
4: Exhibits a violent overreaction such as jumping, biting, squeaking or attack


2) Touch response: Choose the item from the following list that best describes the animal's reaction to being gently touched on the abdomen with a dull object (e.g., tweezers) (scored).


1: No reaction
2: Slowly retreats/normal
3: Twitches (muscular tenseness)
4: Exhibits a violent overreaction such as jumping, biting, squeaking or attack


3) Eyelid reflex: Choose the item from the following list that best describes the animal's reflex upon being touched on the eyelid with a dull object (e.g., tweezers) (scored).


1: Does not blink
2: Blinks/normal


4) Pinna reflex: Choose the item from the following list that best describes the animal's twitch reflex upon being touched on the auricle with a dull object (e.g., tweezers) (scored).


1: Auricle does not twitch
2: Auricle twitches/normal


5) Sound response: Choose the item from the following list that best describes the twitch reflex of the animal's body upon having a clicker sounded approximately 5 cm from its back (scored).


1: No reaction
2: Mild reaction, hears sound/normal
3: Twitches (muscular tension)


6) Tail pinch response: Choose the item from the following list that best describes the animal's response to pain upon having the base of its tail squeezed with tweezers or a similar implement (scored).


1: No reaction
2: Looks back, moves forward and lightly squeaks/normal
3: Twitches (muscular tension)
4: Exhibits a violent overreaction such as jumping, biting, squeaking or attack


7) Pupillary reflex: Shine a penlight in the animal's eyes (scored).


1: Does not contract
2: Contracts


8) Righting reflex: Choose the item from the following list that best describes the animal's response to being dropped, belly up, from a height of 30 cm. Skip if animal is paralyzed or in an extremely poor state (scored).


1: Lands on four limbs/normal
2: All limbs do not touch at once
3: Lands on side
4: Lands on back