Strain information
 NBRP Rat No: 0029  Strain name: KMI/Tky  Commmon Name: KMI, Komeda miniature rat Ishikawa Rat Genome Database
Principal Investigator:  Eiichi Kawamoto  Tokyo Medical University       6-1-1 Shinjuku, Shinjuku-ku,    160-8402 Tokyo     JAPAN
Tel: 03-3351-6141    Fax: 03-3350-8689 Email:
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/ ../images/Photos/
Coat Color  albino (c)
Inbred Generations  
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability Ishikawa Laboratory Animals
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Prkg2: protein kinase, cGMP-dependent, type II
Origin Miniature Rat Ishikawa derived from a breeding colony of Wistar rats at the Ishikawa Animal Laboratory (Saitama). Introduced to Tokyo Medical College.
Strain characteristics Experimental model for pituitary miniaturism with an autosomal recessive mode of inheritance. Body growth in MRI was retarded in 56% and 71% of normal control rats for males and females, respectively.
Breeding Conditions Heterozygous female and homozygous male are selected to cross by the phenotype.
Genotyping Genotyping protocol for prkg2
References Chikuda H, Kugimiya F, Hoshi K, Ikeda T, Ogasawara T, Shimoaka T, Kawano H, Kamekura S, Tsuchida A, Yokoi N, Nakamura K, Komeda K, Chung UI, Kawaguchi H
Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes.
Genes Dev 1;18(19):2418-29, 2004.

Serizawa N.
[Initial characterization of a new miniature animal model in the rat: studies on anatomy, pituitary hormones and GH mRNA in miniature rat Ishikawa]
Nippon Naibunpi Gakkai Zasshi 20;69(1):33-45, 1993.

Tsuchida A, Yokoi N, Namae M, Fuse M, Masuyama T, Sasaki M, Kawazu S, Komeda K.
Phenotypic characterization of the Komeda miniature rat Ishikawa, an animal model of dwarfism caused by a mutation in Prkg2.
Comp Med. 58(6):560-7, 2008.
Additional strain information KMI