Strain information
 NBRP Rat No: 0002  Strain name: ACI-Lystbg-Kyo/Kyo  Commmon Name: ACI/NKyo-Lystbg-Kyo/Kyo, ACI/NKyo-Lystbg-Kyo, ACI/N-bg Rat Genome Database
Principal Investigator:  Tadao Serikawa  Graduate School of Medicine, Kyoto University       Yoshidakonoe-cho, Sakyo-ku    606-8501 Kyoto     JAPAN
Tel: 075-753-4360    Fax: 075-753-4409 Email:
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/ACI_N-bg/331a%20(Large).jpg ../images/Photos/ACI_N-bg/331z%20(Large).jpg
Coat Color  beige (A,B,hi,bg)
Inbred Generations  F35+F27 (May 2009)
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Lyst: lysosomal trafficking regulator
Origin Spontaneous mutation from ACI/NKyo inbred at Kyoto University in 1999.
Strain characteristics This mutant rat shows beige coat color, giant granule cells in various tissues, and prolonged bleeding time. This mutant strain is a disease model for human Chediak-Higashi syndrome (CHS). This mutation is a deletion of about 20 kb containing exons 28, 29 and 30, which constitute the 578 bp sequence missing in the Lyst cDNA on rat chromosome 17. This mutant gene is allelic to Lystbe (DA-beige rat) but the putative deletion break points in L1 elements were different from it (Mori, 2003). The nested PCR-RFLP analysis is useful to discriminate Lystbe-Kyo from Lystbe (Masui, 2004). (May 21, 2009)
Breeding Conditions Maintained by crossing of homozygoutes. Litter size is small.
References 山崎賢一、中西聡、北田一博、芹川忠夫、西川哲、並木千晶、浜田修一、橋本敦



Mori M, Yamasaki K, Nakanishi S, Kitada K, Higuchi K, Namiki C, Hamada S, Serikawa T.

A new beige mutant rat ACI/NKyo-Lyst

Exp. Anim. 52(1), 31-36, 2003.

Masui N, Mori M, Nishikawa T, Takagi Y, Asai H, Yanabe M, Yamasaki K, Serikawa T, Sato K.

An allele-specific genotyping method for rat lyst (lysosomal trafficking regulator) gene.

Exp Anim. 2004 53(1):77-80.
Additional strain information ACI