京都大学大学院医学研究科 実験動物学分野研究室

(附属動物実験施設)

業績

原著論文・総説

 

2021年

    Morita K., Hatanaka Y., Ihashi S., Asano M., Miyamoto K., Matsumoto. Symmetrically dimethylated histone H3R2 promotes global transcription during minor zygotic genome activation in mouse pronuclei. Scientific Reports volume 11, Article number: 10146 (2021) DOI: 10.1038/s41598-021-89334-w

 

    Uemura, N., Ueda, J., Yoshihara, T., Ikuno, M., Uemura, M.T., Yamakado, H., Asano, M., Trojanowski, J.Q., Takahashi, R. “α-Synuclein spread from olfactory bulb causes hyposmia, anxiety, and memory loss in BAC-SNCA mice”. Movement Disorder. 2021 Feb 6. doi: 10.1002/mds.28512.

 

    Hoang Trung, H., Yoshihara, T., Nakao, A., Hayashida, K., Hirata, Y., Shirasuna, K., Kuwamura, M., Nakagawa, Y., Kaneko, T., Mori, Y., Asano, M., and Kuramoto, T. “Deficiency of the RIβ subunit of protein kinase A causes body tremor and impaired fear conditioning memory in rats.” Scientific Reports 11:2039, 2021.

 

    Takarada-Iemata, M., Yoshihara, T., Okitani, N., Iwata, K., Hattori, T., Ishii, H., Roboon, J., Nguyen, D.T., Fan, Q., Tamatani, T., Nishiuchi, T., Asano, M., and Hori O. “Abnormal social behavior and altered gene expression in mice lacking NDRG2.” Neurosci Lett. 743:135563, 2021.

 

2020年

    Asano, M. “Various biological functions of carbohydrate chains learned from glycosyltransferase-deficient mice.”  Exp. Anim. 69: 261-268, 2020.

 

    成瀬智恵,浅野雅秀 神経幹細胞の分化におけるヒストン修飾因子HP1の役割 Clinical Neuroscience 38(12) 1513-15, 2020.

 

    Li M, Nishio SY, Naruse C, Riddell M, Sapski S, Katsuno T, Hikita T, Mizapourshafiyi F, Smith FM, Cooper LT, Lee MG, Asano M, Boettger T, Krueger M, Wietelmann A, Graumann J, Day BW, Boyd AW, Offermanns S, Kitajiri SI, Usami SI, Nakayama M. Digenic inheritance of mutations in EPHA2 and SLC26A4 in Pendred syndrome. Nature Communications. 11(1):1343, 2020.

 

    Naruse C, Abe K, Yoshihara T, Kato T, Nishiuchi T, Asano M. Heterochromatin protein 1γ deficiency decreases histone H3K27 methylation in mouse neurosphere neuronal genes. FASEB J. 34(3):3956-3968, 2020.

 

    Nishitani A, Nagayoshi H, Takenaka S, Asano M, Shimizu S, Ohno Y, Kuramoto T. Involvement of NMDA receptors in tremor expression in Aspa/Hcn1 double-knockout rats. Exp. Anim. 69(4):388-394, 2020.

 

2019年

    Honda, A., Tachibana, R., Hamada, K., Morita, K., Mizuno, N., Morita, K., and Asano, M. “Efficient derivation of knock-out and knock-in rats using embryos obtained by in vitro fertilization.” Scientific Reports 9: 11571, 2019.

 

    Nishitani, A., Yoshihara, T., Tanaka, M., Kuwamura, M., Asano, M., Tsubota, Y., and Kuramoto, T. “Muscle weakness and impaired motor coordination in Hcn1-deficient rats.” Exp. Anim. 69(1):11-17.2019.

 

    Takagaki, S., Yamashita, R., Hashimoto, N., Sugihara, K., Kanari, K., Tabata, K., Nishie, T., Oka, S., Miyanishi, M, Naruse, C., and Asano, M. “Galactosyl carbohydrate residues on hematopoietic stem/progenitor cells are essential for homing and engraftment to the bone marrow.” Scientific Reports 9: 7133, 2019.

 

    Yamamoto, Y., Liang, M., Munesue, S., Deguchi, K., Harashima, A., Furuhara, K., Yuhi, T., Zhong, J., Akther, S., Goto, H., Eguchi, Y., Kitao, Y., Hori, O., Shiraishi, Y., Ozaki, N., Shimizu, Y., Kamide, T., Yoshikawa, A., Hayashi, Y., Nakada, M., Lopatina, O., Gerasimenko, M., Komleva, Y., Malinovskaya, N., Salmina, A.B., Asano, M., Nishimori, K., Shoelson, S.E., Yamamoto, H., and Higashida, H. “Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice.” Communications Biology 2: 76, 2019.

 

    Nishitani, A., Kunisawa, N., Sugimura, T., Sato, K., Yoshida, Y., Suzuki, T., Sakuma, T., Yamamoto, T., Asano, M., Saito, Y., Ohno, Y., and Kuramoto, T. “Loss of HCN1 subunits causes absence seizures in rats.” Brain Research 1706: 209-217, 2019.

 

2018年

    Yoshihara, T., Satake, H., Nishie, T., Okino, N., Hatta, T., Otani, H., Naruse, C., Suzuki, H., Sugihara, K., Kamimura, E., Tokuda, N., Furukawa, K., Furukawa, K., Ito, M., and Asano, M. “Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in mice.” PLOS Genetics 14: e1007545, 2018.

 

    Nakajima, S., Imamura, R., Yoshino, M., Sakurai, M., Tsuchiya, K., Sugihara, K., Asano, M., and Suda, T. “Characterization of innate and adaptive immune responses in PYNOD-deficient mice.” ImmunoHorizons, 2018 ImmunoHorizons 2: 129-141, 2018.

 

2017年

    Naruse, C., Shibata, S., Tamura, M., Kawaguchi, T., Abe, K., Sugihara, K., Kato, T., Nishiuchi, T., Wakana, S., Ikawa, M., and Asano, M. “New insights on the role of Jmjd3 and Utx in axial skeletal formation in mice.” FASEB Journal 31(6): 2252-2266, 2017  doi: 10.1096/fj.201600642R

 

    Sun, M., Ha, N., Pham, D-H., Frederick, M., Sharma, B., Naruse, C., Asano, M., Pipkin, M., George, R. and Thai, To-Ha. “Cbx3/HP1γ deficiency confers enhanced tumor killing capacity on CD8+ T cells.” Scientific Reports 7: 42888, 2017.

 

 

 

2015年以前

2015年

    Sato, T., Ishikawa, M., Yoshihara, T., Nakazato, R., Asano, M., and Yoshioka, K. “Critical role of JSAP1 and JLP in axonal transport in cerebellar Purkinje cells of mice.” FEBS Lett.2805-2811, 2015.

 

    Wu, W., Nishikawa, H., Fukuda, T., Vittal, V., Asano, M., Miyoshi, Y., Klevit, R.E. and Ohta, T. “Interaction of BARD1 and HP1 is required for BRCA1 retention at sites of DNA damage.” Cancer Research 75: 1311-1321, 2015.

 

    Yaji, S., Manya, H., Nakagawa, N., Takematsu, H., Endo, T., Kannagi, R., Yoshihara, T., Asano, M. and Oka, S. “Major glycan structure underlying expression of the Lewis X epitope in the developing brain is O-mannose-linked glycans on phosphacan/RPTPβ.” Glycobiology 25: 376-385, 2015.

 

2014年

    Ha, N., Pham, D-H., Naruse, C., Asano, M., and Thai, T-H. “HP-1γ controls high-affinity antibody response to T-dependent antigens.” Frontiers in Immunology 5: 271, 2014.

 

    *Lopatina, O., *Yoshihara, T., *Nishimura, T., Zhong, J., Akther, S., Fakhrul, A.A., Liang, M., Higashida, C., Sumi, K., Furuhara, K., Inahata, Y., Huang, J., Koizumi, K., Yokoyama, S., Tsuji, T., Petugina, Y., Sumarukov, A., Salmina, A.B., Hashida, K., Kitao, Y., Hori, O., Asano, M., Kitamura, Y., Kozaka, T., Shiba, K., Zhong, F., Xie, M-J., Sato, M., Ishihara, K., and Higashida, H. “Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson’s disease.” Frontiers in Behavioral Neuroscience 8: 133, 2014. *equal contribution.

 

2013年

    Cui, H., Okamoto, Y., Yoshioka, K., Du, W., Takuwa, N., Zhang, W., Asano, M., Shibamoto, T., and Takuwa, Y. “Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice. ” J. Allergy Clin. Immunol. 132: 1205-14 doi: 10.1016/j.jaci.2013.07.026.

 

    Ohno, R., Nakayama, M., Naruse, C., Okashita, N., Takano, O., Tachibana, M., Asano, M., Saitou, M., and Seki, Y. “A replication-dependent passive mechanism modulates DNA demethylation in mouse primordial germ cells.” Development 140: 2892-2903, 2013.

 

    Hase, K., Nakatsu, F., Ohmae, M., Sugihara, K., Shioda, N., Takahashi, D., Obata, Y., Furusawa, Y., Fujimura, Y., Yamashita, T., Fukuda, S., Okamoto, H., Asano, M., Yonemura, S., and Ohno, H. “AP-1B-mediated protein sorting regulates polarity and proliferation of intestinal epithelial cells in mice.” Gastroenterology 145: 625-635, 2013.

 

    Nadanaka, S., Zhou, S., Kagiyama, S., Shoji, N., Sugahara, K., Sugihara, K., Asano, M. and Kitagawa, H. “EXTL2, a member of the EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner.” J. Biol. Chem. Mar 29;288(13):9321-33, 2013.

 

    *Liu, H-X., *Lopatina, O., Higashida, C., Fujimoto, H., Akther, S., Inzhutova, A., Liang, M., Zhong, J., Tsuji, T., Yoshihara, T., Sumi, K., Ishiyama, M., Ma, W-J., Ozaki, M., Yagitani, S., Yokoyama, S., Mukaida, N., Sakurai, T., Hori, O., Yoshioka, K., Hirao, A., Kato, Y., Ishihara, K., Kato, I., Okamoto, H., Cherepanov, S.M., Salmina, A.B., Hirai, H., Asano, M., Brown, D.A., Nagano, I., and Higashida, H. “Displays of paternal mouse pup retrieval following communicative interaction with maternal mates.” Nat. Commun. 4: 1346, 2013. *equal contribution.

 

    Thundyil, J., Manzanero, S., Pavlovski, D., Cully, T.R., Lok, K.Z., Widiapradja, A., Chunduri, P., Jo, D.G., Naruse, C., Asano, M., Launikonis, B.S., Sobey, C.G., Coulthard, M.G., and Arumugam, T.V. “Evidence that the EphA2 receptor exacerbates ischemic brain injury.” PLoS ONE 8:e53528, 2013.

 

2012年

    Yoshioka, K., Yoshida, K., Cui, H., Wakayama, T., Takuwa, N., Okamoto, Y., Du, W., Qi, X., Asanuma, K., Sugihara, K., Aki, S., Miyazawa, H., Biswas, K., Nagakura, C., Ueno, M., Iseki, S., Schwartz, J. R., Okamoto, H., Sasaki, T., Matsui, O., Asano, M., Adams, H. R., Takakura, N., and Takuwa, Y. “Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function.” Nat. Med. 18: 1560-1569, 2012.

 

    Sugahara, D., Kaji, H., Sugihara, K., Asano, M., and Narimatsu, H. “Large-scale identification of target proteins of a glycosyltransferase isozyme by Lectin-IGOT-LC/MS, an LC/MS-based glycoproteomic approach.” Scientific Reports, 2: 680, 2012.

 

    Yamaguchi, K., Shiozaki, K., Moriya, S., Koseki, K., Wada, T., Tateno, H., Sato, I., Asano, M., Iwakura, Y., and Miyagi, T. “Reduced susceptibility to colitis-associated colon carcinogenesis in mice lacking plasma membrane-associated sialidase.” PLoS ONE 7: e41132, 2012.

 

    Sato, A., Ohtaki, H., Tsumuraya, T., Song, D., Ohara, K., Asano, M., Iwakura, Y., Atsumi, T., and Shioda, S. “Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury.” J Neuroinflammation 9: 65, 2012.

 

    Shinzaki, S., Iijima, H., Fujii H., Kuroki, E., Tatsunaka, N., Inoue, T., Nakajima, S., Egawa, S., Kanto, T, Tsujii, M., Morii, E., Takeishi, S., Asano, M., Takehara, T., Hayashi, N. and Miyoshi, E. “Altered oligosaccharide structures reduce colitis induction in mice defective in β-1,4-galactosyltransferase.” Gastroenterology 142: 1172-1182, 2012.

 

    Ito, M., Sugihara, K., Asaka, T., Toyama, T., Yoshihara, T., Furuichi, K., Wada, T., Asano, M. “Glycoprotein Hyposialylation Gives Rise to a Nephrotic-Like Syndrome That Is Prevented by Sialic Acid Administration in GNE V572L Point-Mutant Mice.” PLoS ONE7(1): e29873. 2012.

 

2011年

    Yamamoto, Y., Harashima, A., Saito, H., Tsuneyama, K., Munesue, S., Motoyoshi, S., Han, D., Watanabe, T., Asano, M., Takasawa, S., Okamoto, H., Shimura, S., Karasawa, T., Yonekura, H., and Yamamoto, H. “Septic shock is associated with receptor for advanced glycation end products ligation of LPS.” J. Immunol., 186: 3248-3257, 2011.

 

    Kouno, T., Kizuka, Y., Nakagawa, N., Yoshihara, T., Asano, M. and Oka, S. "Specific enzyme complex of β-1, 4-

galactosyltransferase-II and GlcAT-P facilitates biosynthesis of N-linked HNK-1 carbohydrate." J. Biol. Chem. 286: 31337-31346, 2011.

 

    *Takada, Y., *Naruse, C., *Costa, Y., Shirakawa, T., Tachibana, M., Sharif, J., Kezuka-Shiotani, F., Kakiuchi, D., Masumoto, H., Shinkai, Y., Ohbo, K., Peters, A.H., Turner, J.M., #Asano, M. and #Koseki, H. "HP1γ links histone methylation marks to meiotic synapsis in mice." Development. 2011 Oct;138(19):4207-17. *equal contribution. #equal correspondence.

 

    Abe, K., Naruse, C., Kato, T., Nishiuchi, T., Saitou, M., and Asano, M. "Loss of heterochromatin protein 1γ reduces the number of primordial germ cells via impaired cell-cycle progression." Biol. Reprod., 85: 1013-1024, 2011.

 

2010年

    Nishie T, Hikimochi Y, Zama K, Fukusumi Y, Ito M, Yokoyama H, Naruse C, Ito M, Asano M. "β4-galactosyltransferase-5 is a lactosylceramide synthase essential for mouse extra-embryonic development." Glycobiology, 20: 1311-22, 2010.

 

    Izumikawa, T., Kanagawa, N., Watamoto, Y., Okada, M., Saeki, M., Sakano, M., Sugahara, K., Sugihara, K., Asano, M., and Kitagawa, H. “Impairment of embryonic cell Division and glycosaminoglycan biosynthesis in glucuronyltransferase-I deficient mice.” J. Biol. Chem., 285: 12190-12196, 2010.

 

    Kato, Y., Kubo, Y., Iwata, D., Kato, S., Sudo, T., Sugiura, T., Kagaya, T., Wakayama, T., Hirayama, A., Sugimoto, M., Sugihara, K., Kaneko, S., Soga, T., Asano, M., Tomita, M., Matsui, T., Wada, M., and Tsuji, A. “Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1.” Pharm. Res., 27: 832-840, 2010.

 

    Zhao, Y., Zhang, X., Guda, K., Lawrence, E., Sun, Q., Watanabe, T., Iwakura, Y., Asano, M., Wei, L., Yang, Z., Zheng, W., Dawn Dawson, D., Willis, J., Markowitz, S.D., Satake, M., and Wang, Z. “Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T.” Proc. Natl. Acad. Sci. USA, 107; 2592-2597, 2010.

 

    Du, W., Takuwa, N., Yoshioka, K., Okamoto, Y., Gonda, K., Sugihara, K., Fukamizu, A., Asano, M., and Takuwa, Y. “S1P2, the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice.” Cancer Research 70: 772-781, 2010.

 

2009年

    Tamase, A., Muraguchi, T., Naka, K., Tanaka, S., Kinoshita, M., Hoshii, T., Ohmura, M., Shugo, H., Ooshio, T., Nakada, M., Sawamoto, K., Onodera, M., Matsumoto, K., Oshima, M., Asano, M., Saya, H., Okano, H., Suda, T., Hamada, J., and Hirao, A. “Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin.” Proc. Natl. Acad. Sci. USA 106: 17163-17168, 2009.

 

    Takahashi, I., Noguchi, N., Nata, K., Yamada, S., Kaneiwa, T., Mizumoto, S., Ikeda, T., Sugihara, K., Asano, M., Yoshikawa, T., Yamauchi, A., Shervani, N.J., Uruno, A., Kato, I., Unno, M., Sugahara, K., Takasawa, S., Okamoto, H., and Sugawara, A. “Important role of heparan sulfate in postnatal islet growth and insulin secretion.” Biochem. Biophys. Res. Commun. 383: 113-118, 2009.

 

    Irie, N., Takada, Y., Watanabe, Y., Matsuzaki, Y., Naruse, C., Asano, M., Iwakura, Y., Suda, T., and Matsuo, K. “Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis.” J. Biol. Chem. 284: 14637-14644, 2009.

 

    *Yoshihara, T., *Sugihara, K., Kizuka, Y., Oka, S., and Asano, M. “Learning/memory impairment and reduced expression of the HNK-1 carbohydrate in β4-galactosyltransferase-II-deficient mice.” J. Biol. Chem. 284: 12550-12561, 2009. *equal contribution.

 

    *Chan, C.-B., *Abe, M., Hashimoto, N., Hao, C., Williams, I.R., Liu, X., Nakao, S., Yamamoto, A., Li, S.-Y., Hara-Nishimura, I., #Asano, M., and #Ye, K. “Mice lacking asparaginyl endopeptidase (AEP) develop disorders resembling hemophagocytic syndrome.” Proc. Natl. Acad. Sci. USA 106: 468-473, 2009. *equal contribution. #equal correspondence

 

    Ueno, M., Itoh, M., Sugihara, K., Asano, M., and Takakura, N. “Both alleles of PSF1 are required for maintenance of pool size of immature hematopoietic cells and acute bone marrow regeneration.” Blood 113: 555-562, 2009.

 

2008年

    Sato T, Torashima T, Sugihara K, Hirai H, Asano M, Yoshioka K. The scaffold protein JSAP1 regulates proliferation and differentiation of cerebellar granule cell precursors by modulating JNK signaling. Mol Cell Neurosci. 2008 Dec;39(4):569-78. Epub 2008 Aug 30.

 

    Iwanaga A, Wang G, Gantulga D, Sato T, Baljinnyam T, Shimizu K, Takumi K, Hayashi M, Akashi T, Fuse H, Sugihara K, Asano M, Yoshioka K. Ablation of the scaffold protein JLP causes reduced fertility in male mice. Transgenic Res. 2008 Dec;17(6):1045-58. Epub 2008 Jun 24.

 

    Liu Z, Jang SW, Liu X, Cheng D, Peng J, Yepes M, Li XJ, Matthews S, Watts C, Asano M, Hara-Nishimura I, Luo HR, Ye K. Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase. Mol Cell. 2008 Mar 28;29(6):665-78.

 

    Zhang G, Njauw CN, Park JM, Naruse C, Asano M, Tsao H. EphA2 is an essential mediator of UV radiation-induced apoptosis. Cancer Res. 2008 Mar 15;68(6):1691-6.

 

    Kaneda T, Naruse C, Kawashima A, Fujino N, Oshima T, Namura M, Nunoda S, Mori S, Konno T, Ino H, Yamagishi M, Asano M. A novel beta-myosin heavy chain gene mutation, p.Met531Arg, identified in isolated left ventricular non-compaction in humans, results in left ventricular hypertrophy that progresses to dilation in a mouse model. Clin Sci (Lond). 2008 Mar;114(6):431-40.

 

    Fukusumi Y, Naruse C, Asano M. Wtap is required for differentiation of endoderm and mesoderm in the mouse embryo. Dev Dyn. 2008 Mar;237(3):618-29.

 

    Okumura, A, Saito, T., Otani, I., Kojima, K., Yamada, Y., Ishida-Okawara, A., Nakazato, K., Asano, M., Kanayama, K., Iwakura, Y., Suzuki, K., and Yamagoe, S. “Suppressive role of leukocyte cell-derived chemotaxin 2 in mouse anti-type II collagen antibody-induced arthritis." Arthritis & Rheumatism 58: 413-421, 2013.

 

2007年

    Iwanaga A, Sato T, Sugihara K, Hirao A, Takakura N, Okamoto H, Asano M, Yoshioka K. Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death. Neurosci Lett. 2007 Dec 11;429(1):43-8. Epub 2007 Oct 2.

 

    Naruse C, Fukusumi Y, Kakiuchi D, Asano M. A novel gene trapping for identifying genes expressed under the control of specific transcription factors. Biochem Biophys Res Commun. 2007 Sep 14;361(1):109-15. Epub 2007 Jul 10.

 

    Nishie T, Miyaishi O, Azuma H, Kameyama A, Naruse C, Hashimoto N, Yokoyama H, Narimatsu H, Wada T, Asano M. Development of IgA nephropathy-like disease with high serum IgA levels and increased proportion of polymeric IgA in Beta-1,4-galactosyltransferase-deficient mice. Contrib Nephrol. 2007;157:125-8.

 

    Morita Y, Araki H, Sugimoto T, Takeuchi K, Yamane T, Maeda T, Yamamoto Y, Nishi K, Asano M, Shirahama-Noda K, Nishimura M, Uzu T, Hara-Nishimura I, Koya D, Kashiwagi A, Ohkubo I. Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells. FEBS Lett. 2007 Apr 3;581(7):1417-24. Epub 2007 Mar 5.

 

    Jin D, Liu HX, Hirai H, Torashima T, Nagai T, Lopatina O, Shnayder NA, Yamada K, Noda M, Seike T, Fujita K, Takasawa S, Yokoyama S, Koizumi K, Shiraishi Y, Tanaka S, Hashii M, Yoshihara T, Higashida K, Islam MS, Yamada N, Hayashi K, Noguchi N, Kato I, Okamoto H, Matsushima A, Salmina A, Munesue T, Shimizu N, Mochida S, Asano M, Higashida H. CD38 is critical for social behaviour by regulating oxytocin secretion. Nature. 2007 Mar 1;446(7131):41-5. Epub 2007 Feb 7.

 

    Nishie T, Miyaishi O, Azuma H, Kameyama A, Naruse C, Hashimoto N, Yokoyama H, Narimatsu H, Wada T, Asano M. Development of immunoglobulin A nephropathy- like disease in beta-1,4-galactosyltransferase-I-deficient mice. Am J Pathol. 2007 Feb;170(2):447-56.

 

2006年

    Myint KM, Yamamoto Y, Doi T, Kato I, Harashima A, Yonekura H, Watanabe T, Shinohara H, Takeuchi M, Tsuneyama K, Hashimoto N, Asano M, Takasawa S, Okamoto H, Yamamoto H. RAGE control of diabetic nephropathy in a mouse model: effects of RAGE gene disruption and administration of low-molecular weight heparin. Diabetes. 2006 Sep;55(9):2510-22.

 

    Furuichi K, Wada T, Iwata Y, Kokubo S, Hara A, Yamahana J, Sugaya T, Iwakura Y, Matsushima K, Asano M, Yokoyama H, Kaneko S. Interleukin-1-dependent sequential chemokine expression and inflammatory cell infiltration in ischemia-reperfusion injury. Crit Care Med. 2006 Sep;34(9):2447-55.

 

    Miura E, Fukaya M, Sato T, Sugihara K, Asano M, Yoshioka K, Watanabe M. Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain. J Neurochem. 2006 Jun;97(5):1431-46. Epub 2006 Apr 5.

 

    Zhu Y, Saito K, Murakami Y, Asano M, Iwakura Y, Seishima M. Early increase in mRNA levels of pro-inflammatory cytokines and their interactions in the mouse hippocampus after transient global ischemia. Neurosci Lett. 2006 Jan 30;393(2-3):122-6. Epub 2005 Dec 13.

 

2005年

    Ueno M, Itoh M, Kong L, Sugihara K, Asano M, Takakura N. PSF1 is essential for early embryogenesis in mice. Mol Cell Biol. 2005 Dec;25(23):10528-32.

 

    Sato T, Hidaka K, Iwanaga A, Ito M, Asano M, Nakabeppu Y, Morisaki T, Yoshioka K. Impairment of cardiomyogenesis in embryonic stem cells lacking scaffold protein JSAP1. Biochem Biophys Res Commun. 2005 Dec 16;338(2):1152-7. Epub 2005 Oct 21.

 

    Yamamoto Y, Doi T, Kato I, Shinohara H, Sakurai S, Yonekura H, Watanabe T, Myint KM, Harashima A, Takeuchi M, Takasawa S, Okamoto H, Hashimoto N, Asano M, Yamamoto H. Receptor for advanced glycation end products is a promising target of diabetic nephropathy. Ann N Y Acad Sci. 2005 Jun;1043:562-6.

 

    Akagi T, Usuda M, Matsuda T, Ko MS, Niwa H, Asano M, Koide H, Yokota T. Identification of Zfp-57 as a downstream molecule of STAT3 and Oct-3/4 in embryonic stem cells. Biochem Biophys Res Commun. 2005 May 27;331(1):23-30.

 

2004年

    Kagiwada K, Chida D, Sakatani T, Asano M, Nambu A, Kakuta S, Iwakura Y. IL-6, but not IL-1, induction in the brain downstream of Cox-2 is essential for the induction of febrile response against peripheral IL-1α. Endocrinology. 2004 Jul ;145(11):5044-8.

 

    Kitagawa K, Wada T, Furuichi K, Hashimoto H, Ishiwata Y, Asano M, Takeya M, Kuziel WA, Matsushima K, Mukaida N, Yokoyama H. Blockade of CCR2 ameliorates progressive fibrosis in kidney. Am J Pathol. 2004 Jul;165(1):237-46.

    Umemura M, Kawabe T, Shudo K, Kidoya H, Fukui M, Asano M, Iwakura Y, Matsuzaki G, Imamura R, Suda T. Involvement of IL-17 in Fas ligand-induced inflammation. Int Immunol. 2004 Aug;16(8):1099-108.

 

    Saito T, Okumura A, Watanabe H, Asano M, Ishida-Okawara A, Sakagami J, Sudo K, Hatano-Yokoe Y, Bezbradica JS, Joyce S, Abo T, Iwakura Y, Suzuki K, Yamagoe S. Increase in hepatic NKT cells in leukocyte cell-derived chemotaxin 2-deficient mice contributes to severe concanavalin A-induced hepatitis. J Immunol. 2004 Jul 1;173(1):579-85.

 

    Ashino T, Oguro T, Shioda S, Horai R, Asano M, Sekikawa K, Iwakura Y, Numazawa S, Yoshida T. Involvement of interleukin-6 and tumor necrosis factor alpha in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver. Drug Metab Dispos. 2004 Jul;32(7):707-14.

 

    Kotani N, Asano M, Inoue N, Iwakura Y, Takasaki S. Polylactosamine synthesis and branch formation of N-glycans in beta1,4-galactosyltransferase-1-deficient mice. Arch Biochem Biophys. 2004 Jun 15;426(2):258-65.

 

    Mori R, Kondo T, Nishie T, Ohshima T, Asano M. Impairment of skin wound healing in beta-1,4-galactosyltransferase-deficient mice with reduced leukocyte recruitment. Am J Pathol. 2004 Apr;164(4):1303-14.

 

    Kurohara K, Komatsu K, Kurisaki T, Masuda A, Irie N, Asano M, Sudo K, Nabeshima Y, Iwakura Y, Sehara-Fujisawa A. Essential roles of Meltrin beta (ADAM19) in heart development. Dev Biol. 2004 Mar 1;267(1):14-28.

 

    Wang J, Elghazi L, Parker SE, Kizilocak H, Asano M, Sussel L, Sosa-Pineda B. The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation. Dev Biol. 2004 Feb 1;266(1):178-89.

 

2003年

    Furuichi K, Wada T, Iwata Y, Kitagawa K, Kobayashi K, Hashimoto H, Ishiwata Y, Asano M, Wang H, Matsushima K, Takeya M, Kuziel WA, Mukaida N, Yokoyama H. CCR2 signaling contributes to ischemia-reperfusion injury in kidney. J Am Soc Nephrol. 2003 Oct;14(10):2503-15.

 

    Inano A, Sai Y, Nikaido H, Hasimoto N, Asano M, Tsuji A, Tamai I. Acetyl-L-carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2. Biopharm Drug Dispos. 2003 Nov;24(8):357-65.

 

    Nakae, S., Horai, R., Komiyama, Y., Nambu, A., Asano, M., Nakane, A., and Iwakura, Y. The role of IL-1 in the immune system. In Contemporary Immunology: Cytokine Knockouts, 2nd Edition (ed G., Fantuzzi), Humana Press Inc., Totowa, NJ, pp95-109, 2003.

 

    Ohtaki H, Funahashi H, Dohi K, Oguro T, Horai R, Asano M, Iwakura Y, Yin L, Matsunaga M, Goto N, Shioda S. Suppression of oxidative neuronal damage after transient middle cerebral artery occlusion in mice lacking interleukin-1. Neurosci Res. 2003 Mar;45(3):313-24.

 

    Ohtaki H, Takaki A, Yin L, Dohi K, Nakamachi T, Matsunaga M, Horai R, Asano M, Iwakura Y, Shioda S. Suppression of oxidative stress after transient focal ischemia in interleukin-1 knock out mice. Acta Neurochir Suppl. 2003;86:191-4.

 

    Takeda Y, Akasaka K, Lee S, Kobayashi S, Kawano H, Murayama S, Takahashi N, Hashimoto K, Kano M, Asano M, Sudo K, Iwakura Y, Watanabe K. Impaired motor coordination in mice lacking neural recognition molecule NB-3 of the contactin/F3 subgroup. J Neurobiol. 2003 Sep 5;56(3):252-65.

 

    Shirahama-Noda K, Yamamoto A, Sugihara K, Hashimoto N, Asano M, Nishimura M, Hara-Nishimura I. Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice. J Biol Chem. 2003 Aug 29;278(35):33194-9.

 

    Asano M, Nakae S, Kotani N, Shirafuji N, Nambu A, Hashimoto N, Kawashima H, Hirose M, Miyasaka M, Takasaki S, Iwakura Y. Impaired selectin ligand biosynthesis and reduced inflammatory responses in {beta}-1,4-galactosyltransferase-I-deficient mice. Blood. 2003 Sep 1;102(5):1678-85

 

    Nakae S, Komiyama Y, Yokoyama H, Nambu A, Umeda M, Iwase M, Homma I, Sudo K, Horai R, Asano M, Iwakura Y. IL-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response. Int Immunol. 2003 Apr;15(4):483-90.

 

    Li H, Takeda Y, Niki H, Ogawa J, Kobayashi S, Kai N, Akasaka K, Asano M, Sudo K, Iwakura Y, Watanabe K. Aberrant responses to acoustic stimuli in mice deficient for neural recognition molecule NB-2. Eur J Neurosci. 2003 Mar;17(5):929-36.

 

    Kirii H, Niwa T, Yamada Y, Wada H, Saito K, Iwakura Y, Asano M, Moriwaki H, Seishima M. Lack of Interleukin-1{beta} Decreases the Severity of Atherosclerosis in ApoE-Deficient Mice. Arterioscler Thromb Vasc Biol. 2003 Apr;23(4):656-660.

 

    Nakae S, Komiyama Y, Narumi S, Sudo K, Horai R, Tagawa Y, Sekikawa K, Matsushima K, Asano M, Iwakura Y. IL-1-induced tumor necrosis factor-alpha elicits inflammatory cell infiltration in the skin by inducing IFN-gamma-inducible protein 10 in the elicitation phase of the contact hypersensitivity response. Int Immunol. 2003 Feb;15(2):251-60.

 

    Kurisaki T, Masuda A, Sudo K, Sakagami J, Higashiyama S, Matsuda Y, Nagabukuro A, Tsuji A, Nabeshima Y, Asano M, Iwakura Y, Sehara-Fujisawa A. Phenotypic analysis of Meltrin alpha (ADAM12)-deficient mice: involvement of Meltrin alpha in adipogenesis and myogenesis. Mol Cell Biol. 2003 Jan;23(1):55-61.

 

 

2002年

    Sakamaki K, Inoue T, Asano M, Sudo K, Kazama H, Sakagami J, Sakata S, Ozaki M, Nakamura S, Toyokuni S, Osumi N, Iwakura Y, Yonehara S. Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart. Cell Death Differ. 2002 Nov;9(11):1196-206.

 

    Nakae S, Komiyama Y, Nambu A, Sudo K, Iwase M, Homma I, Sekikawa K, Asano M, Iwakura Y. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity. 2002 Sep;17(3):375-87.

 

    Yamamoto S, Oka S, Inoue M, Shimuta M, Manabe T, Takahashi H, Miyamoto M, Asano M, Sakagami J, Sudo K, Iwakura Y, Ono K, Kawasaki T. Mice deficient in nervous system-specific carbohydrate epitope HNK-1 exhibit impaired synaptic plasticity and spatial learning. J Biol Chem. 2002 Jul 26;277(30):27227-31.

 

    Mizushima H, Zhou CJ, Dohi K, Horai R, Asano M, Iwakura Y, Hirabayashi T, Arata S, Nakajo S, Takaki A, Ohtaki H, Shioda S. Reduced postischemic apoptosis in the hippocampus of mice deficient in interleukin-1. J Comp Neurol. 2002 Jun 24;448(2):203-16.

 

    Oguro T, Takahashi Y, Ashino T, Takaki A, Shioda S, Horai R, Asano M, Sekikawa K, Iwakura Y, Yoshida T. Involvement of tumor necrosis factor alpha, rather than interleukin-1alpha/beta or nitric oxides in the heme oxygenase-1 gene expression by lipopolysaccharide in the mouse liver. FEBS Lett. 2002 Apr 10;516(1-3):63-6.

 

    Saijo S, Asano M, Horai R, Yamamoto H, Iwakura Y. Suppression of autoimmune arthritis in interleukin-1-deficient mice in which T cell activation is impaired due to low levels of CD40 ligand and OX40 expression on T cells. Arthritis Rheum. 2002 Feb;46(2):533-44.

 

 

2001年

    Nakae S, Asano M, Horai R, Iwakura Y. Interleukin-1 beta, but not interleukin-1 alpha, is required for T-cell-dependent antibody production. Immunology. 2001 Dec;104(4):402-9.

 

    Nakae S, Naruse-Nakajima C, Sudo K, Horai R, Asano M, Iwakura Y. IL-1 alpha, but not IL-1 beta, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivity. Int Immunol. 2001 Dec;13(12):1471-8.

 

    Morita Y, Maravei DV, Bergeron L, Wang S, Perez GI, Tsutsumi O, Taketani Y, Asano M, Horai R, Korsmeyer SJ, Iwakura Y, Yuan J, Tilly JL. Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function. Cell Death Differ. 2001 Jun;8(6):614-20.

 

    Kotani, N., Asano, M., Iwakura, Y. and Takasaki, S.: Knockout of mouse β1,4-galactosyltransferase-1 gene results in a dramatic shift of outer chain moieties of N-glycans from type 2 to type 1 chains in hepatic membrane and plasma glycoproteins. Biochem. J. 357(Pt 3):827-34, 2001.

 

    Nakae, S., Asano, M., Horai, R., Sakaguchi N. and Iwakura Y.: IL-1 enhances T cell-dependent antibody production through induction of CD40L and OX40 on T cells. J. Immunol.167(1):90-97, 2001.

 

    Boutin, H., LeFeuvre, R.A., Smith, C., Horai, R., Asano, M., Iwakura, Y. and Rothwell, N.J.: Role of IL-1α and IL-1β in ischaemic brain damage. J Neurosci. 2001 Aug 1;21(15):5528-34.

 

    Ozaki, H., Watanabe, Y., Takahashi, K., Kitamura, K., Tanaka, A., Urase, K., Momoi, T., Sudo, K., Sakagami, J., Asano, M., Iwakura, Y. and Kawakami, K.: Six4, putative myogenin gene regulator, is not essential for mouse embryonal development. Mol. Cell. Biol. 21: 3343-3350, 2001.

 

    Naruse-Nakajima, C., Asano, M. and Iwakura, Y.: Involvement of EphA2 in the formation of the tail notochord via interaction with ephrinA1. Mech. Dev. 102: 95-105, 2001.

 

    Fukamauchi, F., Aihara, O., Wang, Y.J., Akasaka, K., Takeda, Y., Horie, M., Kawano, H., Sudo, K., Asano, M., Watanabe, K., Iwakura, Y.: TAG-1-deficient mice have marked elevation of adenosine A1 receptors in the hippocampus. Biochem. Biophys. Res. Commun. 281: 220-226, 2001.

 

    Higashi, Y., Yokogawa, K., Takeuchi, N., Tamai, I., Nomura, M., Hashimoto, N., Hayakawa, J., Miyamoto, K. and Tsuji, A: Effect of gamma-butyrobetaine on fatty liver in juvenile visceral steatosis mice. J Pharm Pharmacol. 53: 527-533, 2001.

 

    Ohashi, R., Tamai, I., Nezu, J., Nikaido, H., Hashimoto, N., Oku, A., Sai, Y., Shimane, M. and Tsuji, A.: Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol. 59: 358-366, 2001.

 

【総説など】

 

○      総説「ガラクトース糖鎖と炎症,発生,神経」浅野雅秀 生化学86: 382-390, 2014年6月.

 

○      「Asparaginyl endopeptidase欠損マウスにおける血球貪食症候群様病態について」浅野雅秀,橋本憲佳

 血液内科 Vol.63, No.6, 634-639, 2011年12月.

 

○      「第5節第2項 糖鎖リガンド」疾患モデルの作製と利用—免疫疾患(seriesモデル動物利用マニュアル),

 浅野雅秀 エル・アイ・シー,p523-529, 2011年6月.

 

○      「第8節 ガラクトース転移酵素」生物機能モデルと新しいリソース・リサーチツール(seriesモデル動物利用マニュアル),

 浅野雅秀 エル・アイ・シー,p346-353, 2011年2月.

 

○      「IgA腎症の発症には糖鎖がからんでいる」 第3の生命鎖:糖鎖の謎が今,解る,浅野雅秀

 クバプロ p123-130,2009年2月.

 

○      「免疫グロブリンAの糖鎖不全と腎臓疾患」 浅野雅秀 蛋白質核酸酵素(2008年9月号増刊),

 共立出版,Vol.53, No.12, 1611-1616, 2008年9月.

 

○      ミニレビュー「IgAの糖鎖不全とIgA腎症」浅野雅秀,西江敏和

 生化学 Vol.79, No.7, 673-678, 2007年7月.

 

○      「β-1,4-ガラクトース転移酵素I(β4GalT-I)遺伝子ノックアウトマウスによる糖鎖機能の解明」未来を拓く糖鎖科学

 (永井克孝監修)浅野雅秀 金芳堂,392, 2005年12月.

 

○      「β4-ガラクトース転移酵素遺伝子欠損とIgA腎症」未来を拓く糖鎖科学(永井克孝監修)

 浅野雅秀 金芳堂,364-365, 2005年12月.

 

○      「IgA腎症と糖鎖不全IgA」糖鎖と病気(谷口直之編集),

 西江敏和,浅野雅秀 遺伝子医学MOOK 3号,メディカルドウ,53-58, 2005年9月.

 

○      「糖転移酵素遺伝子破壊による新たなIgA腎症モデル」

 浅野雅秀,西江敏和 Annual Review 2005腎臓 中外医学社,57-61, 2005年1月

 

○      「遺伝子トラップ法」成瀬智恵,浅野雅秀 発生工学,日本生物工学会 第81巻 第8号 351-354, 2003年8月.

 

○      「糖鎖とIgA腎症」浅野雅秀,西江敏和,宮石理 Molecular Medicine 中山書店Vol. 40, No.9, 1056-1061, 2003年8月.

 

○      「5章分子生物学的方法論,個体を用いる方法」浅野雅秀 改訂第2版 分子生物学イラストレイテッド

 (田村隆明,山本雅編集),羊土社,198-206, 2002年10月.

 

○      「チロシン脱リン酸化酵素δのノックアウトマウスは物覚えが悪い」上谷則子,浅野雅秀,岩倉洋一郎

 細胞工学 秀潤社,1498-1500, 2000年10月.

 

○      「細菌誘導性劇症肝炎モデルにおけるIL-1の役割」浅野雅秀 医学のあゆみ(別冊)

 医歯薬出版,117-120, 2000年7月.

 

○      「遺伝子改変動物研究のめざすもの」,浅野雅秀 モダンメディア 栄研化学 44: 85-90, 1999年3月.

 

○      「6章分子生物学的方法論,関連する技術」浅野雅秀 分子生物学イラストレイテッド(田村隆明,山本雅編集),

 羊土社,203-212, 1998年10月.

 

○      「α-1,3-fucosyltransferase VII」180,「β-1,4-galactosyltransferase」190-191浅野雅秀 ノックアウトマウス・データブック

 (黒川清,笹月健彦監修,野口茂,平井久丸編集),中山書店,1997年12月.

 

○      「転写因子」,浅野雅秀 KEY WORD 1996-97 炎症・免疫系(柏崎禎夫,室田誠逸,垣生園子編集)

 先端医学社,138-139,1996年2月.

 

 

○      「トランスジェニックマウスの作製法」,浅野雅秀,西城忍,岩倉洋一郎 分子医科学実験プロトコール

 (東京大学医科学研究所学友会編集)秀潤社,249-258,1995年12月.

 

 

○      「遺伝子ノックアウトマウスの作製法」,田川陽一,浅野雅秀,岩倉洋一郎 分子医科学実験プロトコール

 (東京大学医科学研究所学友会編集)秀潤社,238-248, 1995年12月.

 

○      「インターフェロン遺伝子を導入したトランスジェニックマウスの作製」,浅野雅秀,岩倉洋一郎

 モダンメディア別冊,34: 610-619, 1988年12月.

 

○      トピックス「トランスジェニックマウスの医学への応用」,浅野雅秀,岩倉洋一郎

 検査と技術,Vol.15, No.11, 1987年10月.