Strain information  NBRP Rat No: 0021  Strain name: WTC.DMY-Mrs2dmy/Kyo  Commmon Name: WTC.DMY-dmy Rat Genome Database Principal Investigator:  Tadao Serikawa  Graduate School of Medicine, Kyoto University       Yoshidakonoe-cho, Sakyo-ku    606-8501 Kyoto     JAPAN Tel: 075-753-4360    Fax: 075-753-4409 Email: serikawa@anim.med.kyoto-u.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  albino (c) Inbred Generations  N12F32 (April 2012) Usage Restrictions   Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Origin A congenic strain established with a background strain WTC at Kyoto University. Strain characteristics A congenic strain established with a background strain WTC. The dmy (demyelination) rat is an autosomal recessive mutant strain that exhibits severe myelin breakdown (demyelination) in the CNS and hind limb ataxia. The causative gene is located on rat Chr 17 and the dmy rat has a point mutation in intron 3 of the Mrs2gene (Kuramoto et al, 2011). Breeding Conditions Maintained in heterozygous condition. Genotyping SSLP markers linked with dmy locus Genotyping protocol for Mrs2 References Kuramoto T, Sotelo C, Yokoi N, Serikawa T, Gonalons Sintes E, Canto Martorell J, Guenet J-L. A rat mutation producing demyelination (dmy) maps to chromosome 17. Mamm Genome. 7: 890-894, 1996. Kitada K. et al Determination of the mouse homologous region for the rat dmy locus. J Exp Anim. Sci. 41:40-43, 2000. Kuwamura M, Kanehara T, Tokuda S, Kumagai D, Yamate J, Kotani T, Nakane Y, Kuramoto T, Serikawa T Immunohistochemical and morphometrical studies on myelin breakdown in the demyelination (dmy) mutant rat. Brain Res. 1;1022(1-2):110-6, 2004 Izawa T, Yamate J, Franklin RJ, Kuwamura M. Abnormal iron accumulation is involved in the pathogenesis of the demyelinating dmy rat but not in the hypomyelinating mv rat. Brain Res. 2010 Aug 19;1349:105-14. Kuramoto T, Kuwamura M, Tokuda S, Izawa T, Nakane Y, Kitada K, Akao M, Guénet JL, Serikawa T. A mutation in the gene encoding mitochondrial Mg²+ channel MRS2 results in demyelination in the rat. PLoS Genet. 2011 Jan 6;7(1):e1001262. Kuwamura M, Inumaki K, Tanaka M, Shirai M, Izawa T, Yamate J, Franklin RJ, Kuramoto T, Serikawa T. Oligodendroglial pathology in the development of myelin breakdown in the dmy mutant rat. Brain Res. 2011 May 10;1389:161-8. Shimotsuma Y, Tanaka M, Izawa T, Yamate J, Kuwamura M. Enhanced Expression of Trib3 during the Development of Myelin Breakdown in dmy Myelin Mutant Rats. PLoS One. 2016 Dec 15;11(12):e0168250. Kuwamura M, Tanimura S, Hasegawa Y, Hoshiai R, Moriyama Y, Tanaka M, Takenaka S, Nagayoshi H, Izawa T, Yamate J, Kuramoto T, Serikawa T. Downregulation of aspartoacylase during the progression of myelin breakdown in the dmy mutant rat with mitochondrial magnesium channel MRS2 defect. Brain Res. 2019 Sep 1:1718:169-175. Additional strain information WTC DMY