NBRP Rat No: 0021 |
Strain name: WTC.DMY-Mrs2dmy/Kyo |
Commmon Name: WTC.DMY-dmy |
Rat Genome Database |
Principal Investigator: |
Tadao Serikawa Graduate School of Medicine, Kyoto University Yoshidakonoe-cho, Sakyo-ku 606-8501 Kyoto JAPAN |
Tel: 075-753-4360 Fax: 075-753-4409 |
Email: serikawa@anim.med.kyoto-u.ac.jp |
Preservation Status: |
Embryo Sperm Living Animals |
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Coat Color |
albino (c) |
Inbred Generations |
N12F32 (April 2012) |
Usage Restrictions |
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Genetic Status |
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Comercial Availability |
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Research Category |
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Gene Affected |
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Origin |
A congenic strain established with a background strain WTC at Kyoto University. |
Strain characteristics |
A congenic strain established with a background strain WTC. The dmy (demyelination) rat is an autosomal recessive mutant strain that exhibits severe myelin breakdown (demyelination) in the CNS and hind limb ataxia. The causative gene is located on rat Chr 17 and the dmy rat has a point mutation in intron 3 of the Mrs2gene (Kuramoto et al, 2011). |
Breeding Conditions |
Maintained in heterozygous condition. |
Genotyping |
SSLP markers linked with dmy locus
Genotyping protocol for Mrs2 |
References |
Kuramoto T, Sotelo C, Yokoi N, Serikawa T, Gonalons Sintes E, Canto Martorell J, Guenet J-L.
A rat mutation producing demyelination (dmy) maps to chromosome 17.
Mamm Genome. 7: 890-894, 1996.
Kitada K. et al
Determination of the mouse homologous region for the rat dmy locus.
J Exp Anim. Sci. 41:40-43, 2000.
Kuwamura M, Kanehara T, Tokuda S, Kumagai D, Yamate J, Kotani T, Nakane Y, Kuramoto T, Serikawa T
Immunohistochemical and morphometrical studies on myelin breakdown in the demyelination (dmy) mutant rat.
Brain Res. 1;1022(1-2):110-6, 2004
Izawa T, Yamate J, Franklin RJ, Kuwamura M.
Abnormal iron accumulation is involved in the pathogenesis of the demyelinating dmy rat but not in the hypomyelinating mv rat.
Brain Res. 2010 Aug 19;1349:105-14.
Kuramoto T, Kuwamura M, Tokuda S, Izawa T, Nakane Y, Kitada K, Akao M, Guénet JL, Serikawa T.
A mutation in the gene encoding mitochondrial Mg²+ channel MRS2 results in demyelination in the rat.
PLoS Genet. 2011 Jan 6;7(1):e1001262.
Kuwamura M, Inumaki K, Tanaka M, Shirai M, Izawa T, Yamate J, Franklin RJ, Kuramoto T, Serikawa T.
Oligodendroglial pathology in the development of myelin breakdown in the dmy mutant rat.
Brain Res. 2011 May 10;1389:161-8.
Shimotsuma Y, Tanaka M, Izawa T, Yamate J, Kuwamura M.
Enhanced Expression of Trib3 during the Development of Myelin Breakdown in dmy Myelin Mutant Rats.
PLoS One. 2016 Dec 15;11(12):e0168250. |
Additional strain information |
WTC DMY |
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