Strain information
 NBRP Rat No: 0021  Strain name: WTC.DMY-Mrs2dmy/Kyo  Commmon Name: WTC.DMY-dmy Rat Genome Database
Principal Investigator:  Tadao Serikawa  Graduate School of Medicine, Kyoto University       Yoshidakonoe-cho, Sakyo-ku    606-8501 Kyoto     JAPAN
Tel: 075-753-4360    Fax: 075-753-4409 Email:
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/WTC.DMY-dmy/WTC.DMY-dmy_hetero_1024.jpg ../images/Photos/
Coat Color  albino (c)
Inbred Generations  N12F32 (April 2012)
Usage Restrictions  
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected
Origin A congenic strain established with a background strain WTC at Kyoto University.
Strain characteristics A congenic strain established with a background strain WTC. The dmy (demyelination) rat is an autosomal recessive mutant strain that exhibits severe myelin breakdown (demyelination) in the CNS and hind limb ataxia. The causative gene is located on rat Chr 17 and the dmy rat has a point mutation in intron 3 of the Mrs2gene (Kuramoto et al, 2011).
Breeding Conditions Maintained in heterozygous condition.
Genotyping SSLP markers linked with dmy locus Genotyping protocol for Mrs2
References Kuramoto T, Sotelo C, Yokoi N, Serikawa T, Gonalons Sintes E, Canto Martorell J, Guenet J-L.
A rat mutation producing demyelination (dmy) maps to chromosome 17.
Mamm Genome. 7: 890-894, 1996.

Kitada K. et al
Determination of the mouse homologous region for the rat dmy locus.
J Exp Anim. Sci. 41:40-43, 2000.

Kuwamura M, Kanehara T, Tokuda S, Kumagai D, Yamate J, Kotani T, Nakane Y, Kuramoto T, Serikawa T
Immunohistochemical and morphometrical studies on myelin breakdown in the demyelination (dmy) mutant rat.
Brain Res. 1;1022(1-2):110-6, 2004

Izawa T, Yamate J, Franklin RJ, Kuwamura M.
Abnormal iron accumulation is involved in the pathogenesis of the demyelinating dmy rat but not in the hypomyelinating mv rat.
Brain Res. 2010 Aug 19;1349:105-14.

Kuramoto T, Kuwamura M, Tokuda S, Izawa T, Nakane Y, Kitada K, Akao M, Guénet JL, Serikawa T.
A mutation in the gene encoding mitochondrial Mg²+ channel MRS2 results in demyelination in the rat.
PLoS Genet. 2011 Jan 6;7(1):e1001262.

Kuwamura M, Inumaki K, Tanaka M, Shirai M, Izawa T, Yamate J, Franklin RJ, Kuramoto T, Serikawa T.
Oligodendroglial pathology in the development of myelin breakdown in the dmy mutant rat.
Brain Res. 2011 May 10;1389:161-8.

Shimotsuma Y, Tanaka M, Izawa T, Yamate J, Kuwamura M.
Enhanced Expression of Trib3 during the Development of Myelin Breakdown in dmy Myelin Mutant Rats.
PLoS One. 2016 Dec 15;11(12):e0168250.
Additional strain information WTC DMY