NBRP Rat No: 0289 |
Strain name: WTC-Kcnq1dfk/Kyo |
Commmon Name: WTC-dfk, deafness Kyoto |
Rat Genome Database |
Principal Investigator: |
Tadao Serikawa Graduate School of Medicine, Kyoto University Yoshidakonoe-cho, Sakyo-ku 606-8501 Kyoto JAPAN |
Tel: 075-753-4360 Fax: 075-753-4409 |
Email: serikawa@anim.med.kyoto-u.ac.jp |
Preservation Status: |
Embryo Sperm Living Animals |
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Coat Color |
albino (c) |
Inbred Generations |
F23 (May 2009) |
Usage Restrictions |
The recipient of BIOLOGICAL RESOUCE shall obtain a prior written consent on use of it from the DEPOSITOR. For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient. |
Genetic Status |
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Comercial Availability |
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Research Category |
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Gene Affected |
Kcnq1: potassium voltage-gated channel, subfamily Q, member 1 |
Origin |
Rats with abnormal behaviors such as head-tossing, drawing back, stepping back, and circling were discovered in the N12F10 generation of a WTC.ZI-Atrnzi congenic strain at the Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, in 1999. The WTC-Kcnq1dfk/Kyo rat is a mutant for circling behavior. although the Atrnzi allele of WTC.ZI-Atrnzi congenic rats was eliminated, the circling behavior remained. |
Strain characteristics |
Abnormal behaviors such as head-tossing, drawing back, stepping back, and circling. Complete deafness. Inner ear of the WTC-dfk rats showed collapsed endolymph. Prolonged QT interval in the electrocardiogram (ECG) Gastric achlorhydria associated with hypertrophic gastric mucosa. |
Breeding Conditions |
Both male and female rats are fertile. |
Genotyping |
Genotyping protocol for Kcnq1 |
References |
Gohma H, Kuramoto T, Kuwamura M, Okajima R, Tanimoto N, Yamasaki K, Nakanishi S, Kitada K, Makiyama T, Akao M, Kita T, Sasa M, Serikawa T.
WTC deafness Kyoto (dfk): a rat model for extensive investigations of Kcnq1 functions.
Physiol Genomics. 14;24(3):198-206, 2006.
Kuwamura M, Okajima R, Yamate J, Kotani T, Kuramoto T, Serikawa T.
Pancreatic Metaplasia in the Gastro-achlorhydria in WTC-dfk Rat, a Potassium Channel Kcnq1 Mutant.
Vet Pathol. 45(4):586-91, 2008. |
Additional strain information |
WTC |
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