Strain information  NBRP Rat No: 0289  Strain name: WTC-Kcnq1dfk/Kyo  Commmon Name: WTC-dfk, deafness Kyoto Rat Genome Database Principal Investigator:  Tadao Serikawa  Graduate School of Medicine, Kyoto University       Yoshidakonoe-cho, Sakyo-ku    606-8501 Kyoto     JAPAN Tel: 075-753-4360    Fax: 075-753-4409 Email: serikawa@anim.med.kyoto-u.ac.jp Preservation Status:   Embryo        Sperm       Living Animals Coat Color  albino (c) Inbred Generations  F23 (May 2009) Usage Restrictions  The recipient of BIOLOGICAL RESOUCE shall obtain a prior written consent on use of it from the DEPOSITOR. For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient. Genetic Status   Inbred  Segregating   Congenic   Consomic   Recombinant   Coisogenic   Spont. Mutant  Transgene  Ind. Mutant  Category Other  Comercial Availability Research Category   Diabetes Obesity  Neurobiology  Ophthalmology   Dentistry  Cardio Hypertension  Cancer  Metabolism  Otorhinology  Immunology  Infectious  Osteosis   Internal Organ  Dermatology   Reproduction   Development  Behavior  Hematology  Urology   Pharmacology  Research Area Others   Control Strain  Marker Strain Gene Affected Kcnq1: potassium voltage-gated channel, subfamily Q, member 1 Origin Rats with abnormal behaviors such as head-tossing, drawing back, stepping back, and circling were discovered in the N12F10 generation of a WTC.ZI-Atrnzi congenic strain at the Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, in 1999. The WTC-Kcnq1dfk/Kyo rat is a mutant for circling behavior. although the Atrnzi allele of WTC.ZI-Atrnzi congenic rats was eliminated, the circling behavior remained. Strain characteristics Abnormal behaviors such as head-tossing, drawing back, stepping back, and circling. Complete deafness. Inner ear of the WTC-dfk rats showed collapsed endolymph. Prolonged QT interval in the electrocardiogram (ECG) Gastric achlorhydria associated with hypertrophic gastric mucosa. Breeding Conditions Both male and female rats are fertile. Genotyping Genotyping protocol for Kcnq1 References Gohma H, Kuramoto T, Kuwamura M, Okajima R, Tanimoto N, Yamasaki K, Nakanishi S, Kitada K, Makiyama T, Akao M, Kita T, Sasa M, Serikawa T. WTC deafness Kyoto (dfk): a rat model for extensive investigations of Kcnq1 functions. Physiol Genomics. 14;24(3):198-206, 2006. Kuwamura M, Okajima R, Yamate J, Kotani T, Kuramoto T, Serikawa T. Pancreatic Metaplasia in the Gastro-achlorhydria in WTC-dfk Rat, a Potassium Channel Kcnq1 Mutant. Vet Pathol. 45(4):586-91, 2008. Additional strain information WTC