Strain information
 NBRP Rat No: 0289  Strain name: WTC-Kcnq1dfk/Kyo  Commmon Name: WTC-dfk, deafness Kyoto Rat Genome Database
Principal Investigator:  Tadao Serikawa  Graduate School of Medicine, Kyoto University       Yoshidakonoe-cho, Sakyo-ku    606-8501 Kyoto     JAPAN
Tel: 075-753-4360    Fax: 075-753-4409 Email:
Preservation Status:   Embryo        Sperm       Living Animals ../images/Photos/WTC.dfk/681a%20(Large).jpg ../images/Photos/WTC.dfk/681z%20(Large).jpg
Coat Color  albino (c)
Inbred Generations  F23 (May 2009)
Usage Restrictions  The recipient of BIOLOGICAL RESOUCE shall obtain a prior written consent on use of it from the DEPOSITOR. For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.
Genetic Status
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  Category Other 
Comercial Availability
Research Category
 Diabetes Obesity  Neurobiology  Ophthalmology  Dentistry  Cardio Hypertension
 Cancer  Metabolism  Otorhinology  Immunology  Infectious
 Osteosis  Internal Organ  Dermatology  Reproduction  Development
 Behavior  Hematology  Urology  Pharmacology  Research Area Others 
 Control Strain  Marker Strain
Gene Affected Kcnq1: potassium voltage-gated channel, subfamily Q, member 1
Origin Rats with abnormal behaviors such as head-tossing, drawing back, stepping back, and circling were discovered in the N12F10 generation of a WTC.ZI-Atrnzi congenic strain at the Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, in 1999. The WTC-Kcnq1dfk/Kyo rat is a mutant for circling behavior. although the Atrnzi allele of WTC.ZI-Atrnzi congenic rats was eliminated, the circling behavior remained.
Strain characteristics Abnormal behaviors such as head-tossing, drawing back, stepping back, and circling. Complete deafness. Inner ear of the WTC-dfk rats showed collapsed endolymph. Prolonged QT interval in the electrocardiogram (ECG) Gastric achlorhydria associated with hypertrophic gastric mucosa.
Breeding Conditions Both male and female rats are fertile.
Genotyping Genotyping protocol for Kcnq1
References Gohma H, Kuramoto T, Kuwamura M, Okajima R, Tanimoto N, Yamasaki K, Nakanishi S, Kitada K, Makiyama T, Akao M, Kita T, Sasa M, Serikawa T.
WTC deafness Kyoto (dfk): a rat model for extensive investigations of Kcnq1 functions.
Physiol Genomics. 14;24(3):198-206, 2006.

Kuwamura M, Okajima R, Yamate J, Kotani T, Kuramoto T, Serikawa T.
Pancreatic Metaplasia in the Gastro-achlorhydria in WTC-dfk Rat, a Potassium Channel Kcnq1 Mutant.
Vet Pathol. 45(4):586-91, 2008.
Additional strain information WTC