Usage Restrictions
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.
Origin
From a closed colony of Sprague Dawley (SD) rats in the laboratory animal facilities of the Universitat Autónoma de Barcelona (Bellaterra Campus) in 1991. Via Institute Pasteur, Paris, to Kyoto University (1996).
Strain characteristics
DMY rats exhibit hind limb ataxia and severe myelin breakdown in the CNS during the late stage of postnatal myelination (Kuramoto, 1996; Kuwamura, 2004). By genetic analysis, the causative gene dmy (demyelination) was mapped to rat chromosome 17, very close to the prolactin (Prl) locus (Kuramoto, 1996) and the corresponding mouse genomic region was determined on mouse chromosome 13 (Kitada, 2000). DMY rats show an abnormal ion accumulation and significant upregulation of iron regulatory proteins in the spinal cord white matter (Izawa, 2010). (Oct 8, 2010)
Breeding Conditions
Maintained in heterozygous condition.
References
Kuramoto T, Sotelo C, Yokoi N, Serikawa T, Gonalons Sintes E, Canto Martorell J, Guenet J-L.
A rat mutation producing demyelination (dmy) maps to chromosome 17.
Mamm Genome. 7: 890-894, 1996.
Kitada K. et al
Determination of the mouse homologous region for the rat dmy locus.
J Exp Anim. Sci. 41:40-43, 2000.
Kuwamura M, Kanehara T, Tokuda S, Kumagai D, Yamate J, Kotani T, Nakane Y, Kuramoto T, Serikawa T
Immunohistochemical and morphometrical studies on myelin breakdown in the demyelination (dmy) mutant rat.
Brain Res. 2004 Oct 1;1022(1-2):110-6.
Izawa T, Yamate J, Franklin RJ, Kuwamura M.
Abnormal iron accumulation is involved in the pathogenesis of the demyelinating dmy rat but not in the hypomyelinating mv rat.
Brain Res. 2010 Aug 19;1349:105-14.
Kuramoto T, Kuwamura M, Tokuda S, Izawa T, Nakane Y, Kitada K, Akao M, Guénet JL, Serikawa T.
A mutation in the gene encoding mitochondrial Mg²+ channel MRS2 results in demyelination in the rat.
PLoS Genet. 2011 Jan 6;7(1):e1001262.