京都大学医学部附属動物実験施設報　第１号

動物実験施設利用者研究業績

（1992年〜1993年）

 1) 解剖学教室
　　　解剖学第1講座

 2) 医化学教室
　　　医化学第1講座

 3) 病理学教室
　　　病理学第1講座

 4) 感染・免疫学講座

 5) 生体情報科学講座

 6) 内科学教室
　　　内科学第2講座
　　　内科学第3講座

 7) 外科学教室
　　　外科学第1講座
　　　外科学第2講座

 8) 眼科学教室

 9) 婦人科学産科学教室

10) 小児科学教室

11) 皮膚病学黴毒学教室

12) 泌尿器科学教室

13) 耳鼻咽喉科学教室

14) 整形外科学教室

15) 麻酔学教室

16) 脳神経外科学教室

17) 老年医学教室

18) 核医学教室

19) 心臓血管外科学教室

20) 臨床検査医学教室

21) 形成外科学教室

22) 病態栄養部

23) 附属動物実験施設

1）解剖学教室

解剖学第1講座

1) Minote H, Inoue K, Higashide S, Tobe T, Takeuchi E, Mori C, and Shiota K. (1992)Immunohistochemical study on epidermal growth factor (EGF) receptor during carcinogenesis in the rat liver. Arch. Jpn. Chirurg. 61(3), 249-258

2) Higashide S, Inoue K, Minote H, Tobe T, Mori C, and Shiota K. (1992) Expression of epidermal growth factor receptor after partial pancreatectomy in adult rats: An immunohistochemical study. Arch. Jpn. Chirurg. 61(4), 311-319

3) 塩田浩平　(1992) 哺乳類全胚培養の発生毒性学への応用 組織培養 18(3),100-104

4) Arishima K, Yamamoto M, Takizawa T, Shomiya H, Eguchi Y, and Shiota K. (1993) Effect of acute maternal alcohol consumption on the fetal ductus arteriosus in the rat. Biol. Neonate 63(1), 40-43

5) Ukita K, Fukui Y, and Shiota K. (1993) Effects of prenatal alcohol exposure in mice: Influence of an ADH inhibitor and achronic inhalation study. Reprod. Toxicol. 7(3), 273-281 

6) Ukita K, Arishima K, Takizawa T, Shirai M, Yamamoto M, Fukui Y, and Shiota K. (1993) Lack of constrictive effects of cocaine on the fetal ductus arteriosus in the rat. Cong. Anom. 33(2),143-146

7) 塩田浩平 　(1993) 発生毒性試験における in vitro 試験法とその意義について, 関西実験動物研究会誌 No. 13, pp. 37-43

2）医化学教室

医化学第1講座

1) Okamoto M, Murakami M, Shimizu A, Ozaki S, Tsubata T, Kumagai S, and Honjo T. (1992) A transgenic model of autoimmune hemolytic anemia. J. Exp. Med. 175, 71-79

2) Murakami M, Tsubata T, Okamoto M, Shimizu A, Kumagai S, Imura H, and Honjo T. (1992) Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease intransgenic mice. Nature 357, 77-80

3) Shimada M, Yamada Y, Nakakuki Y, Okamoto K, Fukumoto M, Honjo T, and Hiai H. (1993) SL/KH strain of mice: a model of spontaneous pre-B-lymphomas. Leukemia Research 17, 573-578

4) Nisitani S, Tsubata T, Murakami M, Okamoto M, and Honjo T. (1993) The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow. J. Exp. Med. 178, 1247-1254

3）病理学教室

病理学第1講座

1) Hiai H, Yokota Y, and Buma Y. (1992) Epigenetic control of endo-genous MuLV expression and lymphomagenesis by a maternal resistance factor. In: Molecular Approaches to Study and Treatment of Human Diseases, pp171-175, Yoshida, T.O and Wilson, J.M.(eds.) Elsevier Science Publishers B.V. Amsterdam

2) Kubo Y, Nakagawa Y, Kakimi K, Yanagawa Y, Iwashiro M, Kuribayashi K, Masuda T, Hiai H, and Ishimoto A. (1992) The presence of transplantable T lymphoid cells in C57BL/6 mice infected with murine AIDS virus. J. Virol. 66, 5691-5695

3) Yanagawa S, Kakimi K, Tanaka H, Murakami A, Nakagawa Y, Kubo Y, Yamada Y, Hiai H, Kuribayashi K, Masuda T, and Ishimoto A. (1992) Mouse mammary tumor virus with rearranged long terminal repeats causes murine lymphomas. J. Virol. 67, 112-118

4) Lu J, Sakai Y, Wajjawalku W, Isobe K, Saito M, Amo H, Kojima A, Utsumi K.R, Takahashi M, Hiai H, and Matsuyama M. (1992) Establishment of transplantable tumor lines and in vitro cell lines of malignant thymoma developed in a BUF/Mna rat Jpn. J. Cancer Res. 83, 618-624

5) Sawada M, Nishikawa M, Adachi T, Midorikawa O, and Hiai H. (1993) A paneth cell specific zinc-binding protein in the rat: Purification and immunohistochemical localization. Lab. Invest. 68, 338-344

6) Shimada M.O, Yamada Y, Nakakuki Y, Okamoto K, Fukumoto M, Honjo T, and Hiai H. (1993) SL/Kh strain mice: A novel animal model of pre B lymphomas. Leuk. Res. 17, 573-578

7) Sawada M, Midorikawa O, and Hiai H. (1993) Effect of dithizone and purification of zinc-binding protein in rat Paneth cell. Ann. Rep. Interdiscipl. Res. Inst. Environ. Sci. 12, 89-93

4）感染・免疫学講座

1) Iwashiro M, Kondo T, Shimizu T, Yamagishi H, Takahashi K, Matsubayashi Y, Masuda T, Ohtaka A, Fujii N, Ishimoto A, Miyazawa M, Robertson M.N, Chesebro B, and Kuribayashi K. (1993) Multiplicity of Virus-Encoded Helper T-Cell Epitopes Expressed on FBL-3 Tumor Cells. Journal of Virology 67, 4533-4542

2) Teramura Y, Watanabe Y, Kan N, Masuda T, and Kuribayashi K. (1993) Interferon-γ-producing Tumor Induces Host Tumor-specific T Cell Responses. Jpn. J. Cancer Res. 84, 689-696

5）生体情報科学講座

1) Tanabe Y, Masu M, Ishii T, Shigemoto R, and Nakanishi S. (1992) A family of metabotropic glutamate receptors. Neuron 8, 169-179

2) Hori S, Komatsu Y, Shigemoto R, Mizuno N, and Nakanishi S. (1992) Distinct tissue distribution and cellular localization of two mRNAs encoding different subtypes of rat endothelin receptors Endocrinology 130, 1885-1895

3) Abe T, Sugihara H, Nawa H, Shigemoto R, Mizuno N, and Nakanishi S. (1992) Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction J Biol Chem. 267, 13361-13368

4) Sugihara H, Moriyoshi K, Ishii T, Masu M, and Nakanishi S. (1992) Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing. Biochem. Biophys. Res. Commun. 185, 826-832

5) Akazawa C, Sasai Y, Nakanishi S, and Kageyama R. (1992) Molecular characterization of a rat negative regulator with a basic helix-loop-helix structure predominantly expressed in the developing nervous system. J. Biol. Chem. 267, 21879-21885

6) Nakanishi S. (1992) Molecular diversity of glutamate receptors and implications for brain function. Science 258, 597-603

7) Sasai Y, Kageyama R, Tagawa Y, Shigemoto R, and Nakanishi S. (1992) Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes Dev. 6, 2620-2634

8) Ishii T, Moriyoshi K, Sugihara H, Sakurada K, Kadotani H, Yokoi M, Akazawa C, Shigemoto R, Mizuno N, Masu M, and Nakanishi S. (1993) Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J. Biol. Chem. 268, 2836-2843

9) Bessho Y, Nawa H, and Nakanishi S. (1993) Glutamate and quisqualate regulate expression of metabotropic glutamate receptor mRNA in cultured cerebellar granule cells. J. Neurochem. 60, 253-259

10) Nakajima Y, Iwakabe H, Akazawa C, Nawa H, Shigemoto R, Mizuno N, and Nakanishi S. (1993) Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate. J. Biol. Chem. 268, 11868-11873

11) Hayashi Y, Momiyama A, Takahashi T, Ohishi H, Ogawa-Meguro R, Shigemoto R, Mizuno N, and Nakanishi S. (1993) Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb. Nature 366, 687-690

6）内科学教室

内科学第2講座

1) Hashimoto Y, Nakao K, Hama N, Mukoyama M, Imura H, Yasuhara M, and Hori R. (1992) Pharmacokinetics of brain natriuretic peptide in rats. Chem.Pharm.Bull. 40, 1650-1652

2) Himeno A, Niwa M, Nakao K, Suga S, Yamashita K, Kataoka Y, Nakane Y, Imura H, and Taniyama K. (1992) C-type natriuretic peptide-22 differentiates between natriuretic peptide receptors in rat choroid plexus and subfornical organ. Eur. J. Pharmacol. 215, 337-340

3) Itoh H, Nakao K, and Imura H. (1993) Natriuretic peptide system in the brain and its implication in central cardiovascular regulation. In Central Neural Mechanisms in Cardiovascular Regulation volume 2 edited by G.Kunos and J. Ciriello. Birkhauser Publishers, Boston p.266-279

4) Shirakami G, Itoh H, Suga S, Komatsu Y, Hama N, Mori K, and Nakao K. (1993) Central action of C-type natriuretic peptide on vasopressin secretion in conscious rats. Neurosci. Let. 159, 25-28

内科学第3講座

1) Ishida M, Fujiwara H, Kida M, Kawai C, Nakayama S, Yamashita S, Miura I, and Yabuuchi Y. (1992) Protective effect of carteolol, a β-blocker, on myocardial cellular damage in ischemic and reperfused pig hearts: assessment of gated in vivo 31-phosphorus magnetic resonance spectroscopy and electron microscopy. J. Mol. Cell Cardiol 24, 21-34

2) Kawamura A, Fujiwara H, Uegaito T, Tanaka M, and Kawai C. (1992) Comparative effects of diltiazem, nifedipine, and verapamil on large and small coronary artery constriction induced by intracoronary acetylcoline in pigs. J. Cardiovasc Pharmacol 19, 915-921

3) Tanaka M, Fujiwara H, Shibata Y, Kida M, Suzuka H, Kimura K, and Kawai C. (1992) Effects of chronic oral administration of nifedipine and diltiazem on occlusive thrombus of small coronary arteries in (NZW×BXSB)F1 male mice. Cardiovasc Res. 26, 586-592

4) 久萬田俊明、谷尾仁志、林田　済、石川　昇 (1992) 性僧帽弁閉鎖不全に対する強心血管拡張薬（inodilator ) の効果。臨床成人病 22, 1454-1456

5) Miyamae M, Fujiwara H, Kida M, Yokota R, Tanaka M, Katsuragawa M, Hasegawa K, Ohura M, Koga K, and Yabuuchi Y. (1993) Preconditioning improves energy metabolism during reperfusion but does not attenuate myocardial stunning in procine hearts. Circulation 88, 223-234

6) Kida M, Fujiwara H, Uegaito T, Miyamae M, Ohura M, Miura I, and Yabuuchi Y. (1993) Dobutamine prevents both myocardial stunning and phosphocreatine overshoot without affecting ATP level. J. Mol. Cell Cardiol 25, 875-885

7) Katsuragawa M, Fujiwara H, Kawamura A, Htay T, Yoshikuni T, Mori K, and Sasayama S. (1993) An animal model of coronary thrombosis: Comparsion of vascular damage and thrombus formation in the coronary and femoral arteries after balloon angioplasty. Jpn. Cir. J. 57, 1000-1006

7）外科学教室

外科学第1講座

1) 菅　典道、山崎誠二、原田武尚、他 (1992) 癌のリンパ球移入療法の効果増強　−　特に宿主リンパ球と移入リンパ球相互作用の観点から．Human Cell 5(3), 236-242

2) Takaori K, Nio Y, Inoue K, et al. (1992) A comparative study on immunosuppressive effects of cyclosporin A and FK506 on peripheral blood lymphocytes in dogs. Biotherapy 4, 129-137

3) Kogire M, Inoue K, Sumi S, et al. (1992) Effects of gastric inhibitory polypeptide and glucagon on portal venous and hepatic arterial flow in conscious dogs. Dig. Dis. & Sci. 37, 1660-1670

4) Kaji H, Inoue K, Yun M, et al. (1992) Morphological changes of B-cells in canine autotransplanted pancreas. Transplant. Pro. 24, 801-803

5) Higashide S, Inoue K, Minote H, et al. (1992) Expression of epidermal growth factor receptor after partial pancreatectomy in adult rats: An immunohistochemical study. Arch. Jpn. Chir. 61, 311-319

6) Minote H, Inoue K, Higashide S, et al. (1992) Immunohistochemical study on epidermal growth factor (EGF) receptor during carcinogenesis in the rat liver. Arch. Jpn. Chir. 61, 249-258

7) Takaori K, Inoue K, Nio Y, et al. (1992) Basic study on immunological effects of cyclosporin A and FK506 for application to pancreatic transplantation. Transplant. Pro. 24, 894-896

8) Kaji H, Inoue K, Yun M, et al. (1992) Qualitative and quantitative changes of islet cells in autotransplanted pancreas in dogs in relation to glucose metabolism. Pancreas 7, 642-648

9) Inoue.K, Gu Y J, Shinohara S, et al. (1992) Experimental xenotransplantation of isolated adult pig islets. Transplant. Pro. 24, 658

10) Takaori K, Inoue K, Kogire M, et al. (1992) Effect of endothelin on microcirculation of the pancreas. Life Sciences 51, 615-622

11) Inoue K, Fujisato T, Gu Y J, et al. (1992) Experimental hybrid islet transplantation: Application of polyvinyl alcohol membrane for entrapment of islets. Pancreas 7, 562-568

12) Kogire M, Inoue K, Sumi S, et al. (1992) Effects of ethanol and wine on hepatic arterial and portal venous flows in conscious dogs. Digestion 52, 47-54

13) Inoue K, Gu Y J, Shinohara S, et al. (1992) Isolation of adult pig islet; In vitro assessment and xenotransplantation. Int. J. Pancreat. 12, 173-180

14) Takaori K, Inoue K, Kogire M, et al. (1992) Effects of endothelin-3 on splanchnic circulation in dogs. Microcirculation Annual 1992, 71-72

15) Kogire M, Inoue K, Sumi S, et al. (1992) Differential effects of structurally-related gut hormones of the secretin family on hepatic circulation. Microcirculation Annual 1992, 55-56

16) Tsubono M, Nio Y, Tseng C. C, et al. (1992) Experimental chemotherapy for xenograft cell lines of human bile duct and gall bladder cancers in nude mice. J. Surg. Oncol. 51, 274-280

17) Hirano T, Manabe T, Ohshio G, et al. (1992) Improved survival in mice with diet-induced pancreatitis treated with new potent protease inhibitor, E-3123 and a broad spectrum antibiotic, cefmetazole. Arch. Jap. Chir. 61, 213-223

18) Hirano T, Manabe T, Ohshio G, et al. (1992) Protective effects of combined therapy with a protease inhibitor, ONO 3307, and a xanthine oxidase inhibitor, allopurinol on temporary ischemic model of pancreatitis in rats. Arch. Jap. Chir. 61, 224-223

19) Hirano T, Manabe T, Ohshio G, et al. (1992) Effect of short-termed pancreatico-biliary duct obstruction on lysosomal enzyme in rats: protective effect of a potent new protease inhibitor, E-3123. Arch. Jap. Chir. 61, 234-248

20) Nio Y, Kimura H, Tsubono M, et al. (1992) Antitumor activity of 5'-deoxy-5-fluorouridine in human digestive organ cancer xenografts and pyrimidine nucleoside phosphorylase activity in normal and neoplastic tissues from human digestive organs. Anticancer Res. 12, 1141-1146

21) Nio Y, Shiraishi T, Tsubono M, et al. (1992) Comparative effects of a recombinant and a mutein type of granulocyte colony stimulating factor on the growth of meth-A fibrosarcoma with 5-fluorouracil chemotherapy. Biother. (Netherland) 4, 81-86

22) Nio Y, Kimura H, Tsubono M, et al. (1992) A comparative study of antitumor activities of 5'-deoxy- 5-fluorouridine (5'-DFUR) and its prodrug trimethoxybenzoy1-5'-deoxy-5-fluorocytidine (Ro09-1390) on human digestive organ cancer xenograft line transplanted into nude mice. Anti-Cancer Drugs 3, 387-393

23) Hirano T, Manabe T, Imanishi K, et al. (1992) Protective effect of cetraxate hydrochloride on subcellular redistribution on lysosomal enzymes during caerulein-induced acute pancreatitis. Surg. Res. Commun. 11, 321-326

24) Tseng C. C, Nio Y, Tsubono M, et al. (1992) The role of chemotherapy with oral UFT in intravenous combination chemotherapy with cisplatin and 5-fluorouracil for human gastric cancer xenograft lines transplanted in nude mice. Anticancer Res. 12, 1295-1300

25) Morimoto H, Nio Y, Imai S, et al. (1992) Hepatectomy accelerates the growth of transplanted liver tumor in mice. Cancer Detect. Prevent. 16, 137-147

26) 原田武尚、菅　典道 (1993) IL-1の制癌作用．造血因子4(2), 121-127

27) Inoue K, Kawano T, Kogire M, et al. (1993) Microcirculatory response of the pancreas to feeding, sham feeding, and truncal vagotomy in conscious dogs. Pancreas 8, 28-33

28) Kogire M, Inoue K, Doi R, et al. (1993) Pancreatic exocrine deficiency after partial pancreatectomy in conscious dogs. Eur. J. Surg. 159, 283-286

29) Sumi S, Inoue K, Kitagawa K, et al. (1993) A disulfotyrosyl hybrid of CCK and gastrin (Cionin) increases pancreatic blood flow. Microcirculation Annual 1993, 49-50

30) Kogire M, Inoue K, Gu Y J, et al. (1993) Chronic effects of camostate on growth and endocrine function of the pancreas in streptozotocin induced diabetic rats. Pro. Soc. Exp. Biol. & Med. 204, 201-205

31) Echigo Y, Inoue K, Kogire M, et al. (1993) Effects of cyclosporin A and FK506 on acute Pancreatitis in mice. Surg. Forum. 44, 177-178

32) Nio Y, Tsubono M, Morimoto H, et al. (1993) Loxiglumide (CR1505), a cholecystokinin antagonist, specifically inhibits the growth of human pancreatic cancer lines xenografted into nude mice. Cancer 72, 3599-3606

33) Morimoto H, Nio Y, Tsubono M, et al. (1993) Inhibitory effects of a cholecystokinin antagonist, loxiglumide (CR-1505), on the growth of freshly separated and xenografted human pancreatic cancer. J. Surg. Oncol. 53, 47-53

34) 正井良和、仁尾義則、坪野充彦、他 (1992) 肝切除後の肝再生に及ぼすCisplatin 化学療法の影響. 消化器と免疫 27, 268-273

35) 仁尾義則、林　一資、今井正之 (1993) Cisplatin(CDDP)による抗腫瘍免疫能の増強−特に腫瘍細胞の細胞障害性リンパ球に対す る感受性増強について. BIOTHERAPY 7, 1133-1140

36) 正井良和、仁尾義則、坪野充彦、他 (1993) ヒト膵癌のＤＮＡ合成能と制癌剤感受性. 消化器癌 3, 171-176

37) 真辺忠夫、大塩学而、仁尾義則、他 (1993) 膵癌の化学療法、放射線療法. 外科治療 68, 71-77

外科学第２講座

1) Yamaguchi T, Takada Y, Shimahara Y, Kiuchi T, Higashiyama H, Mori K, Kobayashi N, Yamaoka Y, and Ozawa K. (1992) A mixture of nucleosides and a nucleotide alters hepatic energy metabolism 24 hours after hepatectomy in rabbits. The J. Nutr. 122, 340-344

2) Egawa H, Morimoto T, Takeuchi T, Yamaoka Y, Ozawa K, Yamaguchi T, and Yamamoto N. (1992) Extent of ischaemia caused by hepatic vascular exclusion as evaluated in canine model. Clin. Sci. 82, 335-338

3) Tanaka A, Uyama S, Katayama T, Yamamoto N, Tanaka K, Yamaoka Y, and Ozawa K. (1992) The role of enhanced mitochondrial phosphorylation in rat liver transplantation. J. Surg. Res. 52, 59-64

4) Tokunaga T, Zaima M, Tanaka K, Ueda J, Sasaki Y, Yamamoto N, Kikuchi T, Egawa H, Ozaki N, Yamaoka Y, and Ozawa K. (1992) Effects of transection and perfusion in situ on graft viability in partial liver transplantation. Surg. Res. Comm. 13, 1-11

5) Kataoka M, Tanaka A, Yamaoka Y, Egawa H, Yamaguchi T, Takada Y, and Ozawa K. (1992) The role of cytoplasmic Free-ADP in regenerating rabbit liver. J. Lab. Clin. Med. 119, 354-358

6) Takeuchi T, Egawa H, Yamaoka Y, Taki Y, Ueda J, Konishi Y, Yamamoto N, Kagawa R, Washida M, Okamoto R, Kumada K, and Ozawa K. (1992) A prolongation of hepatic vascular exclusion by in situ hypothermic perfusion in dogs. Arch. Surg. 127, 427-431

7) Washida M, Okamoto R, Manaka D, Yokoyama T, Yamamoto Y, Ino K, Yamamoto N, Ozaki N, Shimahara Y, Yamaoka Y, Kumada K, and Ozawa K. (1992) Beneficial effect of combined 3-5-3'- triiodothyronine and vasopressin administration on hepatic energy status and systemic hemodynamics after brain death. Transplant. 54, 44-49

8) Okamura R, Tanaka A, Uyama S, and Ozawa K. (1992) Low-temparature fluorometric techniqu for evaluating the viability of rat liver grafts after simple cold strage. Transplant. Int. 5, 165-169

9) Takada Y, Shimahara Y, Yamaguchi T, Nishizawa F, Mori K, Yamaoka Y, and Ozawa K. (1992) Protective effect of platelet-activating factor antagonist on hepatic energy metabolism following transient hepatic inflow occlusion in rabbits. Circ. Shock 38, 130-137

10) Morimoto T, Ozawa K, and Isselhard W. (1992) Conversion of mitochondrial redox states toward oxidation by prostacyclin in 70% - hepatectomized rats. Res. Exp. Med. 192, 161-168

11) Kitai T, Tanaka A, Tokuka A, Ozawa K, Iwata S, and Chance B. (1992) The changes in the redox distribution of rat liver by ischemia. Anal. Biochem. 206, 131-136

12) Manaka D, Okamoto R, Yokoyama T, Yamamoto Y, Washida M, Ino K, Yamaoka Y, Kumada K, and Ozawa K. (1992) Maintenance of liver graft viabiltiy in the state of brain death: Synergistic effects of vasopressin and epinephrine on hepatic energy metabolism in brain-dead dogs. Transplant. 53, 545-550

13) Tokuka A, Tanaka A, Fujita T, Hayashi M, Kitai T, Yamaoka Y, Ozawa K, and Ohnishi T. (1992) Protective effect of a prostaglandin oligomer on liver mitochondria in situ: Time-shared measurements of fluorescence and reflectance in the cold-preserved rat liver. Transplant. Int. 5, 193-196

14) Nakano M, Sugano M, Terasaki M, Morimoto T, Mashima S, Mitsuyoshi A, Sasaki H, Kumada K, and Ozawa K. (1992) Preserved mitochondrial function by allopurinol despite deteriorated hemodynamics in warm ischemia-damaged canine liver. Res. Exp. Med. 192, 389-399

15) Higashiyama H, Yamaguchi M, Kumada K, Sasaki H, Yamaguchi T, and Ozawa K. (1992) Tolerance of the liver as measured by ketone body ratio and hepatocyte energy charge to 120 minutes acute venous congestion in dogs. Circ. Shock 38, 202-208

16) Iwata S, Tanaka A, and Ozawa K. (1992) Alterations in the proton ATPase activity of rat liver mitochondria after hemorrhagic shock. J. Lab. Clin. Med. 120, 420-427

17) Ino K, Manaka D, Washida M, Yokoyama T, Okamoto R, Yamaoka Y, and Ozawa K. (1993) Effects of triiodothyronine on canine hepatic ischemia caused by pringle's manuever. Surgery 113, 669-675

18) Kataoka M, Tanaka A, Ikai I, Yamaoka Y, Ozawa K, and Chance B. (1993) Kinetic analysis of ATP-synthetase and ATPase in regenerating rabbit liver. Eur. Surg. Res. 25, 91-97

19) Nishizawa H, Tokunaga Y, Sugano M, Tokuka A, Awane M, Kitai T, Zin M, Terasaki M, Takeda T, Morimoto T, Mori K, Tanaka K, Yamaoka Y, and Ozawa K. (1993) Experience of en bloc technique for abdominal organ harvesting for experimental transplantation. Transplantation Proceedings 25, 1942-1943

20) Hayashi M, Tokunaga Y, Fujita T, Tanaka K, Yamaoka Y, and Ozawa K. (1993) The effects of cold preservation on steatotic graft viability in rat liver transplantation. Transplant. 56, 282-287

21) Takahashi K, Yamamoto N, Egawa H, Takeuchi T, Yamaguchi T, Takada Y, Nishizawa F, Takayasu T, Narita M, Mori K, Yamaoka Y, and Ozawa K. (1993) Effect of prostaglandin E1on preservation injury of canine liver grafts preserved in UW solution. Transplant. Int. 6, 245-250

22) Kitai T, Tanaka A, Tokuka A, Tanaka K, Yamaoka Y, Ozawa K, and Hirao K (1993) Quantitative detection of hemoglobin saturation in the liver with near infrared spectroscopy. Hepatology 18, 926-936

23) Tanaka A, Kitai T, Tokuka A, Inomoto T, Kim H.J, Tanaka K, Yamaoka Y, and Ozawa K. (1993) Increased span of oxido-reduction states between pyridine nucleotide and cytochrome c oxidase in the regenerating rabbit liver as measured by arterial ketone body ratio and near-infrared spectroscopy. Research in Experimental Medicine 193, 353-359

24) Kitai T, Tanaka A, Tokuka A, Tanaka K, Yamaoka Y, Ozawa K, and Hirao K. (1993) Changes in the hepatic oxygenation state during hemorrhagic shock and following epinephrine or dextran infusion as assessed by near-infrared spectroscopy. Circ. Shock 41, 197-205

25) Fujita S, Hamamoto I, Nakamura K, Tanaka K, and Ozawa K. (1993) Isolated perfusionof rat livers: effect of temperature on O2 consumption, enzyme release, energy store, and morphology. Archiv fur Japanishe Chirurgie. 62, 58-70

8）眼科学教室

1) Chuang H C, Kawano S, Arai M, Tsukada T, Kita M, Negi A, and Honda Y. (1992) The influence of argon laser panretinal photocoagulation on the rabbit ERG c-wave. Acta Ophthalmol. Copenh. 70, 303-307

2) Kiryu J, Yamamoto F, and Honda Y. (1992) Effects of sodium iodate on the electroretinogram c-wave in the cat. Vision Res. 32, 2221-2227

3) Kimura H, Ogura Y, Moritera T, Honda Y, Wada R, Hyon S H, and Ikada Y. (1992) Injectable microspheres with controlled drug release for glaucoma filtering surgery. Invest. Ophthalmol. Vis. Sci. 33, 3436-3441

4) Ohuchi T, Yoshimura N, Tanihara H, Kuriyama S, Ito S, and Honda Y (1992) Ca2+ mobilization in nontransformed ciliary nonpigmented epithelial cells. Invest. Ophthalmol. Vis. Sci. 33, 1696-1705

5) Ohuchi T, Tanihara H, Yoshimura N, Kuriyama S, Ito S, and Honda Y. (1992) Neuropeptide-induced [Ca2+] i transients in cultured bovine trabecular cells. Invest. Ophthalmol. Vis. Sci. 33, 1676-1684

6) Mandai M, Iwaki M, and Honda Y. (1992) Simple and accurate assay for tyrosine hydroxylase from bovine retina by high-performance liquid chromoatography with fluorescence detection. Ophthalmic Res. 24, 228-233

7) Sakaue H, Kiryu J, Takeuchi A, Yamamoto F, and Honda Y. (1992) Effects of endothelin on retinal blood vessels. Nippon Ganka Gakkai Zasshi 96, 469-472

8) Takahashi M, Honda Y, Ogawa K, and Barka T. (1992) Immunofluorescence localization of cystatins in human lacrimal gland and in the exorbital lacrimal grand of the rat. Acta Ophthalmol. Copenh. 70, 625-631

9) Tanihara H, Yoshida M, and Yoshimura N. (1992) Tumor necrosis factor-alpha gene is expressed in stimulated retinal pigment epithelial cells in culture. Biochem. Biophys. Res. Commun. 187, 1029-1034

10) Takahashi M, Fujimoto T, Honda Y, and Ogawa K (1992) Distributional change of fodrin in the wound healing process of the corneal epithelium. Invest. Ophthalmol. Vis. Sci. 33, 280-285

11) Takahashi M, Honda Y, Ogawa K, and Barka T. (1992) Immunofluorescence localization of cystatins in human lacrimal gland and in the exorbital lacrimal gland of the rat. Acta Ophthalmol. Copenh. 70, 625-631

12) Yoshimura N, Kuriyama S, Ohuchi T, Takemura M, Honda Y, and Hiraoka M. (1992) Hyperthermia reduces the occurrence of proliferative vitreoretinopathy in a rabbit model. Invest. Ophthalmol. Vis. Sci. 33, 404-409

13) Kiryu J, Ogura Y, Moritera T, Yoshimura N, and Honda Y. (1993) Breakdown of the blood-retinal barrier after radiofrequency-induced ocular hyperthermia. Ophthalmologica 206, 107-110

14) Matsumoto M, Takagi H, and Yoshimura N. (1993) Synergistic suppression of retinal pigment epithelial cell proliferation in culture by radiation and hyperthermia. Invest. Ophthalmol. Vis. Sci. 34, 2068-2073

15) Yamamoto F, and Honda Y. (1993) Effects of intravenous iodoacetate and iodate on pH outside rod photoreceptors in the cat retina. Invest. Ophthalmol. Vis. Sci. 34, 2009-2017

16) Yamamoto F, Hiroi K, and Honda Y. (1993) Effects of ischemia-reperfusion on light-evoked alkalinization outside rod photoreceptors in the cat retina. Ophthalmic Res. 1 25, 371-377

17) Yamamoto F, Kiryu J, and Hiroi K. (1993) Effects of iodate on intraretinal b- and c-waves of the cat electroretinogram. Ophthalmologica 206, 152-157

18) 山本文昭、広井佳野、本田孔士 (1992) ネコ視細胞周囲の pＨにおける Iodoacetate および Iodate の影響.　厚生省特定疾患　網脈絡膜萎縮症調査研究班　平成３年度報告書,　67ｰ69

19) 山本文昭、桐生純一、愛川裕子、広井佳野、本田孔士 (1992) 猫網膜におけるIodate 硝子体注入および静注の影響．-電気生理学的検討- 厚生省特定疾患網脈絡膜萎縮症調査研究班　平成３年度報告書，53ｰ55

20) 山本文昭、本田孔士 (1993) イオン選択性ガラス微小電極法による虚血−再潅流網膜の病態生理学的研究. 病態生理　12，396-399

21) 広井佳野、山本文昭、本田孔士 (1993) 猫網膜電図におけるオルニチンの影響　−急性実験での検討−．厚生省特定疾患　網脈絡膜萎縮症調査研究班　平成４年度報告書，77-79

22) 三住千明、清水久雄、本田治、大平明弘、本田孔士、淀井淳司（1993） 酸化ストレスによる Adult T cell Leukemia Derived Factor (ADF/TRX) の網膜内誘導、厚生省特定疾患　網脈絡膜萎縮症調査研究班　平成４年度報告書，30

23) 柏井聡、高橋政代、万代道子、清水久雄、笹征史、赤池昭紀、本田孔士（1993） 網膜遅発性細胞壊死に対するドーパミンの保護作用、厚生省特定疾患　網脈絡膜萎縮症調査研究班　平成４年度報告書，42

24) 田辺晶代、吉村長久、本田孔士 (1993) ラット網膜における NMDA receptor および metabotropic glutamate receptor mRNAs の局在、厚生省特定疾患　網脈絡膜萎縮症調査研究班　平成４年度報告書，19

9）婦人科学産科学教室

1) Noda Y. (1992) Embryonic development in vitro. Assisted Reproduction Reviews 2, 9-15

2) Goto Y, Noda Y, Narimoto K, Umaoka Y, Tokura T, and Mori T. (1992) Pregnancy achieved by transferring blastocysts into endometrial stroma in mice. Human Reproduction 7, 681-684

3) Goto Y, Noda Y, Narimoto K, Umaoka Y, and Mori T. (1992) Oxidative stress on mouse embryo development in vitro. Free Radical Biology and Medicine 13, 47-53

4) Goto Y, Noda Y, Narimoto K, Umaoka Y, and Mori T. (1992) Estrous cycle independent embryo growth promoting activity of mouse uterus. Journal of Reproduction and Development 38, 211-217

5) Umaoka Y, Noda Y, Narimoto K, and Mori T. (1992) Effects of oxygen toxicity on early development of mouse embryos. Molecular Reproduction and Development 31, 28-33

6) Umaoka Y, Noda Y, Nakayama T, Narimoto K, Mori T, and Iritani A. (1992) Effect of visual light on in vitro embryonic development in the hamster. Theriogenology 38, 1043-1054

7) Natsuyama S, Noda Y, Narimoto K, Umaoka Y, and Mori T. (1992) Release of two-cell block by reduction of protein disulfide with thioredoxin from Escherichia coli. Journal of Reproduction and Fertility 95, 649-656

8) Tokura T, Noda Y, Narimoto K, Umaoka Y, Mori T, and Ogawa K. (1992) Effects of superoxide dismutase on development following the implantation stage in mice. Acta Histochemica and Cytochemica 25, 491-498

9) Noda Y, Narimoto K, Umaoka Y, Natsuyama S, and Mori T. (1993) Analysis of oviduct-derived embryonic growth stimulator activity. International Journal of Fertility 38, 57-64

10) Goto Y, Noda Y, Mori T, and Nakano M. (1993) Increased generation of reactive oxygen species in embryos cultured in vitro. Free Radical Biology and Medicine 15, 69-75

11) Goto Y, Noda Y, Shiotani M, Kishi J, Nonogaki T, and Mori T. (1993) The fate of embryos transferred into the uterus. Journal of Assisted Reproductio and Genetics 10, 197-201

12) Goto Y, Noda Y, Narimoto K, Shiotani M, Tokura T, Umaoka Y, Natsuyama S, Mori T, and Ogawa K. (1993) Oviduct-derived embryo growth promoting activity: A comparison of three ductal organs. Journal of Reproduction and Development 39, 85-89

13) Umaoka Y, Noda Y, Nakayama T, Narimoto K, Mori T, and Iritani A. (1993) Development of hamster one-cell embryos recovered under different conditions to the blastocyst stage. Theriogenology 39, 485-498

14) Matsumoto H, Noda Y Goto Y, Kishi J, Nonogaki T, and Mori T. (1993) The effect of heavy metal ions on the in vitro development of mouse embryos: A comparison of the developmental ability between Ham's F-10 and α-MEN. Journal of Reproduction and Development 39, 223-228

15) Natsuyama S, Noda Y, Yamashita M, Nagahama Y, and Mori T. (1993) Superoxide dismutase and thioredoxin restore defective p34cdc2 kinase activation in mouse two-cell block. Biocheimica et Biophysica Acta 1176, 90-94

16) Natsuyama S, Noda Y, and Mori T. (1993) Role of protein supplements in the culture of mouse embryos. Theriogenology 40: 149-157

17) Nakayama T, Noda Y, Umaoka Y, Narimoto K, and Mori T. (1993) Development to the four-cell stage of hamster embryos fertilized in vitro. Theriogenology 39, 1221-1233

18) Tokura T, Noda Y, Goto Y, and Mori T. (1993) Sequential observation of mitochondrial distribution in mouse oocytes and embryos. Journal of Assisted Reproduction and Genetics 10, 417-426

19) 後藤康夫、野田洋一、森　崇英 (1992)  子宮内膜と初期胚発育. 日本受精着床学会雑誌　第 9 巻, 13-15

20) 岸　淳二、野田洋一、成本勝彦、森　崇英 (1992)  リン酸がラット初期胚発生に与える影響. 日本受精着床学会雑誌　第9巻, 214-215

21) 夏山　知、野田洋一、馬岡　陽、成本勝彦、森　崇英 (1992) 金属イオンキレート物質による初期胚発生促進効果とその意. 日本受精着床学会雑誌 第 9 巻, 216-218

22) 野田洋一、後藤康夫、馬岡　陽、松本　央、森　崇英 (1993) 哺乳類初期胚の in vitro 発生停止の一因は酸化的ストレスによる. Medical Immunology 第 26 巻　第 5 号, 557-565

10）小児科学教室

1) Shirasaka H, Ito M, Mikawa H, Serikawa T, and Yamada J. (1992) Alterations of benzodiazepine receptor binding in tremor rats with absence-like seizures. J. Neurochem. 58, 2292-2295

2) Tsuda H, Ito M, Oguro K, Mutoh K, Shiraishi Y, Shirasaka H, and Mikawa H. (1993) Age- and seizure-related changes in noradrenaline and dopamine in several brain regions of epileptic El mice. Neurochem Res. 18, 111-117

3) Mitsuyoshi I, Ito M, Shirasaka H, Mikawa H, Serikawa T, and Yamada J. (1993) Changes of NMDA receptor binding in spontaneously epileptic rat and parent strains. Neurochem. Res. 18, 1169-1173

4) 武藤庫参、伊藤正利、津田英夫、白石英幸、奥野武彦、小黒克彦、白坂幸義、三河春樹 (1992) Ｅｌマウスの深部脳波の検討． Neurosciences 18, 135-138

5) 奥野武彦、武藤庫参、三河春樹 (1992) 先天性水頭症ラットＨＴＸ系における聴性脳幹反応−刺激頻度の潜時、振幅に対する影響ｰ. 厚生省特定疾患難治性水頭症調査研究班平成３年度研究報告書, 58-63

6) 武藤庫参、毎原敏郎、服部春生、奥野武彦、三河春樹 (1992) 先天性水頭症ラットＨＴＸ系における視覚誘発電位−刺激頻度による変化の検討−．厚生省特定疾患難治性水頭症調査研究班平成４年度研究報告書, 90-95

11）皮膚病学黴毒学教室

1) Ikai K, Shimizu K, Kanauchi H, Ando Y, Furukawa F, and Imamura S. (1992) The presence of autoantibody to lipocortin-I in autoimmune-prone MRL mice (correspondence). Autoimmunity 12, 239 

2) Guo Z-P, Okamoto H, and Imamura S. (1992) The effect of 1,25 (OH)2-vitamin D3 on Langerhans cells and contact hypersensivity in mice (short communication). Arch. Dermatol. Res. 284, 368-370

3) Guo Z-P, Okamoto H, Danno K, and Imamura S. (1992) The effects of non-interval PUVA treatment on Langerhans cells and contact hypersensivity. J. Dermatol. Sci. 3, 91-96

4) Guo Z-P, Okamoto H, Danno K, and Imamura S. (1992) The effects of 1,25 (OH)3 D2 and non-interval PUVA on LCs and contact hypersensivity. Proceedings of the 3rd China-Japan Joint Meeting of Dermatology, 43

5) Hamanaka H, Miyachi Y, Imamura S. (1992) Photoprotection of guinea pig skin by superoxide dismutase: comparison with sunscreen. Cytoprotection Cytobiol. 9, 241-246

6) Danno K, Ikai K, Imamura S. (1993) Anti-inflammatory effects of eicosapentaenoic acid on experimental skin inflammation models. Arch. Dermatol. Res. 285, 432-435

7) Sayeed QK, Danno K, Horiguchi Y, Imamura S. (1993) Lectin staining of the endothelial cell membrane is more sensitive to ultraviolet radiation than the epidermal cell staining in guinea-pig skin. J. Dermatol. Sci. 5, 190-196

8) Furukawa F, Ohshio G, Imamura S. (1993) Pathogenesis of lupus dermatoses in autoimmune mice. XIX. Attempts to induce subepidermal immunoglobulin deposition in MRL/Mp-+/+ mice. Arch. Dermatol. Res. 285, 20-26

9) Imazu LE, Tachibana T, Danno K, Imamura S. (1993) Histamine-releasing factor(s) in sera of uraemic pruritus patients in a possible mechanism of UVB therapy. Arch. Dermatol. Res. 285, 723-727

10) 金内日出男 (1992) ＳＬＥの皮膚病変発症における免疫担当細胞の研究：外的因子と遺伝的背景との関連について. 日本リディアオリリー協会平成３年度年報 71-74

11) 立花隆夫，今津ルーシア笑子，戸田憲一，段野貴一郎，今村貞夫 (1992) 慢性腎不全患者の痒に対する光化学療法の作用機序について：肥満細胞に及ぼすＵＶＢの直接的，間接的影響．皮膚科紀要 593-598

12）泌尿器科学教室

1) Yu A, Hashimura T, Nishio Y, Kanamaru H, Fukuzawa S, and Yoshida.O. (1992) Antipromoting Effgct of Nordihydroguaiaretic acid on N-Butyl-N-(4-hydroxybutyl)nitrosamine and Sodium Saccharin-induced Rat Urinary Bladder Carcinogenesis. Jpn. J. Cancer Res. 83, 944-948

2) 橋村孝幸、日裏　勝、吉田　修、寺村康史、栗林景容、渡部好彦（1993） 膀胱癌細胞へのIFN-γ遺伝子導入による癌免疫療法．泌尿紀要 39, 1205ー1208

13) 耳鼻咽喉科学教室

1) 川野道夫、伊藤寿一、本庄　巌、他（1992） 言語習得前失聴小児に対する人工内耳装着後のリハビリテーション　Audiol Jpn. 35, 367-368

2) Fujino K, Ito J, and Tsuji J. (1993) Efferent vestibular fibers to otolith organs in guinea pigs. Acta Oto-Larungologica 113(5), 598-600

3) 内藤　泰、内藤恵理、本庄　巌（1993） 前庭神経節細胞のシトクロム酸化酵素活性　Equilibrium Res. 52(4), 552-558

14）整形外科学教室

1) Kawanabe K, Yamamuro T, Kotani S, and Nakamura T. (1992) Acute nehprotoxicity as an adverse effect after intraperitoneal injection of massive amounts of bioactive ceramic powders in mice and rats. J. Biomed. Mater. Res. 26, 209-219

2) Neo M, Kotani S, Fujita T, Nakamura T, and Yamamuro T. (1992) Differences in ceramic-bone interface between surface-active ceramics and resorbable ceramics: A study by scanning and transmission electron microscopy. J. Biomed. Mater. Res. 26, 255-267 

3) Takahashi S, Sugimoto M, Kotoura Y, Oka M, Sasai K, Abe M, and Yamamuro T. (1992) Long-lasting tolerance of articular cartilage after experimental intraoperative radiation in rabbits. Clin. Orthop. 275, 300-305

4) Ohura K, Nakamura T, Yamamuro T, Ebisawa Y, Kokubo T, Kotoura Y, and Oka M. (1992) Bioactivity of CaO.SiO2 glasses added with various ions. J. Mater. Sci. : Materials in Medicine 3, 95-100

5) Kotani S, Yamamuro T, Nakamura T, Kitsugi T, Fujita Y, Kawanabe K, and Kokubo T. (1992) Enhancement of bone bonding to bioactive ceramics by demineralized bone powder. Clin. Orthop. 278, 226-234

6) Suzuki K, Shimizu K, Hamamoto T, Nakagawa Y, Murachi T, and Yamamuro T. (1992) Characterization of proteoglycan degradation by calpain. Biochem. J. 285, 857-862

7) Kitsugi T, Yamamuro T, Nakamura T, Yoshii S, Kokubo T, Takagi M, and Shibuya T. (1992） Influence of substituting B₂O₃ for CaF₂ on the bonding behaviour to bone of glass-ceramics containing apatite and wollastonite. Biomaterials 13, 393-399

8) Iwasaki R, Yamamuro T, Kotoura Y, Okumura H, Kasai R, and Nakashima Y. (1992） Immunohistochemical study of bone GLA protein in primary bone tumors. Cancer 70, 621-624

9) Fujita Y, Yamamuro T, Nakamura T, Kitsugi T, Kotani S, Ohtsuki C, and Kokubo T. (1992) Mechanism and strength of bone bonding between two bioactive ceramics in vivo. J. Biomed. Mater. Res. 26, 1311-1324

10) Neo M, Kotani S, Nakamura T, Yamamuro T, Ohtsuki C, Kokubo T, and Bando Y. (1992) A comparative study of ultrastructures of the interface between four kinds of surface-active ceramic and bone. J. Biomed. Mater. Res. 26, 1419-1432

11) Sugimoto M, Toguchida J, Kotoura Y, Yamamuro T, and Utsumi H. (1992)　Intrinsic radiosensitivity and PLD repair in osteosarcoma cell lines. Int. J. Radiat. Biol 62, 469-474

12) Matsusue Y, Yamamuro T, Oka M, Shikinami Y, Hyon S-Y, and Ikada Y .(1992) In vitro and in vivo studies on bioabsorbable ultra-high-strength poly (L-lactide) rods. J. Biomed. Mater. Res. 26, 1553-1567

13) Yoshii S, Yamamuro T, Nakamura T, Oka M, Takagi H, and Kotani S. (1992) Glass-ceramic implant in acetabular bone defect: An experimental study. J. Appl. Biomater. 3, 245-249

14) Ikeda T, Kohno H, Yamamuro T, Kasai R, Ohta S, Okumura H, Konishi J, Kikuchi H, and Shigeno C. (1992) The effect of active Vitamine D3 analog and dexamethasone of the expression of osteocalcin gene in rat tibiae in vivo. Biochem. Biophys. Res. Commun. 189, 1231-1235

15) Neo M, Nakamura T, Tamamuro T, Ohtsuki C, and Kokubo T. (1992) Transmission electron microscopic study of apatite formation on bioactive ceramics in vivo. Ducheyne P, Kokubo T and van Blitterswijk, C.A. ed. Bone-Bonding Biomaterials, Leiderdrop, Leed Healthcare Communications 111-120

16) Kawanabe K, Yamamuro T, Nakamura T, Kokubo T, Yoshihara Y, and Shibuya T. (1992) A new bioactive bone cement consisting of BIS-GMA resin and bioactive glass-powder. idem 233-239

17) Takatsuka K, Yamamuro T, Nakamura T, Kitsugi T, Kotani S, Shibuya T, Okunaga K, and Goto T. (1992) Dvelopment of new bioactive glass-ceramic coating on titanium alloy: Modification of apatite-wollastonite containing glass-ceramic. idem 267-274

18) Nishimura N, Taguchi Y, Yamamuro T, Nakamura T, Kokubo T, and Yoshihara S. (1993) A study of the bioactive bone cement-bone interface: Quantitative and histological evaluation. J. Appl. Biomater. 4, 29-38

19) Kitsugi T, Yamamuro T, Nakamura T, Kotani S, Kokubo T, and Takeuchi H. (1993) Four calcium phosphate ceramics as bone substitutes for non-weight-bearing. Biomater. 14, 216-224

20) Kawanabe K, Tamura J, Yamamuro T, Nakamura T, Kokubo T, and Yoshihara S. (1993) A new bioactive bone cement consisting of BIS-GMA resin and bioactive glass power. J. Appl. Biomater. 4, 135-142

21) Kitsugi T, Yamamuro T, Nakamura T, Oka M, and Kokubo T. (1993) Influence of disodium (1-hydroxythylidene) diphosphonate on bonding between glass-ceramic containig apatite and wollastonite and mature male rabbit bone. Calcif. Tissue Int. 52, 378-385

22) Matsuda Y, Yamamuro T, Okaumura H, Ido K, and Nakamura T. (1993) Glass ceramic augmentation of the acetabulum: Total hip arthroplasties in 24 dogs. Acta Orthop. Scand. 64, 277-281

23) Neo M, Nakamura T, Ohtsuki C, Kokubo T, and Yamamuro T. (1993) Apatite formation on three kinds of bioactive material at an early stage in vivo: A comparative study by transmission electron microscopy. J. Biomed. Mater. Res. 27, 999-1006

24) Nakagawa Y, Shimizu K, Hamamoto T, Kotani S, and Yamamuro T. (1993) Electron microscopy of calcification during high-density suspension culture of chondrocytes. Calcif. Tissue Int. 53, 127-134

25) Takatsuka K, Yamamuro T, Kitsugi T, Nakamura T, Shibuya T, and Goto T. (1993) A new bioactive glass-ceramic as a coating material on titanium alloy. J. Appl. Biomater. 4, 317-329

26) Fujimori K, Shimizu Kat, Suzuki Y, Nakagawa Y, Yamamoto S, and Yamamuro T. Immunohistochemical demonstration of calcium-dependent cysteine proteinase (calpain) in collagen-induced arthritis in mice. Zetschr. f. Rheumatol. 

27) Ikenaga M, Ohura K, Yamamuro T, Kotoura Y, Oka M, and Kokubo T. Localized hyperthermic treatment of experimental bone tumors with ferromagnetic ceramics. J. Orthop. Res.

28) Ikenaga M, Ohura K, Kotoura Y, Yamamuro T, Nakamura T, Oka M, Hiraoka M, and Abe M. Hyperthermic treatment of canine tibia through RF inductive heating of an intramedullary nail: A new experimental approach to hyperthermia for metastatic bone tumors. Int. J. Hypertherm.

29) Nakagawa Y, Shimizu Kat, Hamamoto T, Suzuki K, Ueda M, and Yamamuro T. Calcium-dependent neutral proteinase (Calpain) in fracture healing of rats. J. Orthop. Res.

30) Ijiri S, Yamamuro T, Nakamura T, Kotani S, Shibuya T, Notoya K, and Sato Y. (1993) Ectopic bone induction in porous A-W glass ceramic combined with bone morphogenetic protein. Ducheyne P, Christiansen, D. ed. Bioceramics Vol.6, 15-20 Butterworth Heinemann, Philadelphia

31) Tamura J, Kawanabe K, Yamamuro T, Nakamura T, Kokubo T, Yoshihara S, and Shibuya T. (1993) Bioactive bone cement - Effect of amount of glass powder on its bioactivity and mechanical properties. Ducheyne P, Christiansen, D. ed. Bioceramics Vol.6, 463-468 Butterworth Heinemann, Philadelphia

32) Ijiri S, Yamamuro T, Nakamura T, Kotani S, and Notoya K. Effect of sterilization on bone morphogenetic protein. J. Orthop. Res. 33) Neo M, Nakamura T, Ohtsuki C, Kasai R, Kokubo T, and Yamamuro T. Ultrastructural study of the A-W G-C-bone interface after long-term implantation in rat and human bone. J. Biomed. Mater. Res. 28:

33) Neo M, Nakamura T, Ohtsuki C, Kasai R, Kokubo T, and Yamamuro T. Ultrastructural study of the A-W G-C-bone interface after long-term implantation in rat and human bone. J. Biomed. Mater. Res. 28:

34) Sugimoto M, Takahashi S, Kotoura Y, Shibamoto Y, Takahashi M, Abe M, Ishizaki K, and Yamamuro T. (1993) Osteocyte viability after high-dose irradiation in the rat. Clin. Orthop. Rel. Res. 297, 247-252

35) Matsuda Y, and Yamamuro T. Matallosis due to abnormal abrasion of the femoral head in bipolar hip prosthesis: Implant retrieval and analysis in six cases. J. Long-Term Effect Med. Impl.

15）麻酔学教室

1) Murayama T, Shingu K, Ogawa T, Tomoda K, Shindo K, Tamai S, and Mori K. (1992) Flumazenil does not antagonize halothane, thiamylal or propofol anaesthesia in rats. Br. J. Anaesth. 69, 61-4

2) Ogawa T, Shingu K, Shibata M, Osawa M, and Mori K. (1992) The divergent actions of volatile anaesthetics on background neuronal activity and reactive capability in the central nervous system in cats. Can. J. Anaesth. 39, 862-72

3) Toda H, Nakamura K, Hatano Y, Nishiwada M, Kakuyama M, and Mori K. (1992) Halothane and isoflurane inhibit endothelium-dependent relaxation elicited by acetylcholine. Anesth. Analg 75, 198-203

4) Yakushiji T, Nakamura K, Hatano Y, and Mori K. (1992) Comparison of the vasodilator effects of thiopentone and pentobarbitone. Can. J. Anaesth. 39, 604-9

5) Nakamura K, Hatano Y, Hirakata H, Nishiwada M, Toda H, and Mori K. (1992) Direct vasoconstrictor and vosodilator effects of propofol in isolated dog arteries. Br. J. Anaesth. 68, 193-197

6) Toda H, Nakamura K, Hatano Y, and Mori K. (1992) Direct vascular effect of ropivacaine in femoral artery and vein of the dog. Anesthesiology 77, A650

7) Fukuda K, Kato S, Mori K, Nishi M, and Takeshima H. (1993) Primary structures and expression from cDNAs of rat opioid receptor delta- and mu-subtypes. Febs. Lett. 327, 311-4

8) Kito K, Arai T, Mori K, Morikawa S, and Inubushi T. (1993) Hepatic blood flow and energy metabolism during hypotension induced by prostaglandin E1 and nicardipine in rabbits: an in vivo magnetic resonance spectroscopic study. Anesth. Analg. 77, 606-12

9) Nakamura K, Toda H, Hatano Y, and Mori K. (1993) Comparison of the direct effects of sevoflurane, isoflurane and halothane on isolated canine coronary arteries. Can. J. Anaesth. 40, 257-61

10) Nakamura K, Toda H, Kakuyama M, Nishiwada M, Yamamoto M, Hatano Y, and Mori K. (1993) Direct vascular effect of ropivacaine in femoral artery and vein of the dog. Acta. Anaesthesiol Scand 37, 269-73

11) Nakao S, Arai T, Mori K, Yasuhara O, Tooyama I, and Kimura H. (1993) High-dose ketamine does not induce c-Fos protein expression in rat hippocampus. Neurosci. Lett. 151, 33-6

12) Tomoda K, Shingu K, Osawa M, Murakawa M, and Mori K. (1993) Comparison of CNS effects of propofol and thiopentone in cats. Br. J. Anaesth. 71, 383-7

13) Terasako K, Nakamura K, Toda H, Hatano Y, and Mori K. (1993) Barturates inhibit both endothelium-dependent and independent relaxation mediated by cGMP. Anesthesiology 79, A659

14) Yamamoto M, Kakuyama M, Nakamura K, Tachibana T, and Hatano Y. (1993) Effects of halothane, isoflurane, and sevoflurane on sarcoplasmic reticulum of vascular smooth muscle in dog mesenteric artery. Anesthesiology 70, A603

16）脳神経外科学教室

1) Hashimoto K, Kikuchi H, Ishikawa M, and Kobayashi S. (1992) Changes in cerebral energy metabolism and calucium levels in relation to delayed neuronal death after ischemia. Neurosci. Lett. 137, 165-168

2) Hashimoto K, Kikuchi H, Ishikawa M, and Kobayashi S. (1992) Regional imaging of brain tissue calucium ions using aequorin. J. Cereb. Blood. Flow. Metab. 12, 306-310

3) Nakahara I, Kikuchi H, Taki W, Nishi S, Kito M, Yonekawa Y, Goto Y, and Ogata N. (1992) Changes in major phospholipids of mitochondria during post ischemic reperfusion in rat brain. J. Neurosurg. 76, 244-250

4) Yanamoto H, Kikuchi H, Okamoto S, and Nozaki K. (1992) Preventive effect of synthetic serine protease inhibitor, FUT-175, on cerebral vasospasm in rabbits. Neurosurgery 30-, 351-357

5) Kim C, Cervos-Navarro J, Kikuchi H, Hashimoto N, and Hazama F. (1992) Alterations in cerebral vessels in experimental animals and their possible relationship to the development of aneurysms. Surg. Neurol. 38, 331-337

6) Yoshizumi H, Fujibayashi Y, and Kikuchi H. (1993) A new approach to the integrity of dual blood-brain barrier functions of globa ischemic rats Barrier and carrier functions. Stroke 24, 279-285

7) Nishi S, Taki W, Uemura Y, Higashi T, Kikuchi H, Kudoh H, Satoh M, and Nagata K (1993) Ischemic tolerance due to the induction of HSP 70 in a rat ischemic and recirculation model. Brain. Res. 615, 281-288

8) 南川　順（1992）.　Magnetic resonance imaging (MRI) 及び Magnetic resonance spectrscopy (MRS) を用いた先天 性水頭症の病態及び治療に関する実験的研究.　日本外科宝函　61,35-61

17）老年医学教室

1) Otani H, Kita T, Ueda Y, Kawai C, Takama T, Matsuzawa Y, Nakaya N, Ishihara H, Domae N, Yoshii M, and Miyazaki S. (1992) Long-term effects of a cholesterol-free diet on serum cholesterol levels in zen monks. N. Engl. J. Med. 326, 416

2) Nagano Y, Nakamura T, Matsuzawa Y, Cho M, Ueda Y, and Kita T. (1992) Probucol and atherogenic effect and effects on established plaques. Atherosclerosis 92, 131-140

3) Hara S, Nagano Y, Sasada M, and Kita T. (1992) Probucol pre-treatment enhances the chemotaxis of mouse peritoneal macrophages. Arteriosclerosis and Thrombosis 12, 593-600

4) Arai H, Nagano Y, Narumiya S, and Kita T. (1992) Decreased arachidonate metabolism in mouse peritoneal macrophages after foam cell transformation with oxidized low-density lipoproteins. J. Biochem. 112, 482-487

5) Yoshioka H, et al. (1992) Immunohistochemical demonstration of a new thiamine diphosphate-binding proteins in the rat digestive tract. Histochemistry 97, 121-124

6) Kita T, Yokode M, Ishii K, Kume N, Nagano Y, Arai H, Otani H, Ueda Y, and Hara S. (1992) The role of oxidized lipoproteins in the pathogenesis of atherosclerosis. Clinical and Experimental Pharmacology and physiology 19 (Suppl.20), 37-42

7) Iiyama M, Shimada Y, Kita T, and Ito H. (1992) Effect of aging on macrophage adherence to extracellular matrix proteins. Mechanisms of Ageing and Development 66, 149-158

8) Kita T, Yokode M, Arai H, Iiyama M, Ueda Y, Ueyama K, and Narumiya S. (1993) Cigarette smoke, LDL and cholesteryl ester accumulation in macrophages. Ann. N.Y. Acad. Sci. 686, 91-98

9) Ueda Y, Arai H, Kawashima A, Nagano Y, Cho M, Tanaka M, and Kita T. (1993) Different expression of modified low density lipoprotein receptors in rabbit peritoneal macropahges and Kupffer cells. Atherosclerosis 101, 25-35

10) Tanaka M, Jingami H, Otani H, Cho M, Ueda Y, Arai H, Nagano Y, Doi T, and Kita T. (1993) Regulation of apolipoprotein B production and secretion in response to the change of intracellular cholesteryl ester contents in rabbit hepatocytes. J. Biol. Chem. 268, 12713-12718

11) Wakatsuki Y, et al. (1993) Cross-linking CD40 by receombinant murine ligands induces B cell proliferation and directs isotype differentiation. In Current Topics in Mucosal Immunology 1993, pp75-81. Tsuchiya M, Yodoi J, Hibi T, and Miura S, (eds.), EXcerpta Medica Amsterdam.

12) Watanabe S, Wakatsuki Y, et al (1993) Biochemical and Histological studies of liver fatty acid binding protein in alcohol-treated rats. J. Clin. Biochemia et Cytochemica 14, 1771-181

13) Usui T, et al. (1993) Age-associated change in Th1 like and Th2 like helper T cells in the Peyer's patch of senescence-accelerated mice. In Current Topics in Mucosal Immunology 1993, pp283-285 Excerpta Medica, Amsterdam. 14) Yoshioka H, et al. (1993) Spontaneous development of anti-collagen type Ii antibodies with NTA, and anti-DNA antibodies in senescence-accelerated mice. Autoimmunity 14, 215-220

15) 吉岡秀幸（1993）　消化管免疫の最近の進歩　- パイエル板の免疫を中心に -.　 医学の歩み、167(4), 221

18）核医学教室

1) Kondo S, Nakatsu S, Sakahara H, Kobayashi H, Konishi J, and Namba Y. (1993) Antitumor activity of an immunoconjugate composed of anti-human astrocytoma monoclonal antibody and neocarzinostatin. 　Eur. J. Cancer 29, 420-423

2) Sakahara H, Saga T, Endo K, Hattori N, Hosono M, Kobayashi H, Shirato M, Yamamuro T, Toyama S, Arano Y, Yokoyama A, and Konishi J. (1993) In vivo instability of reduction-mediated 99mTc-labeled monoclonal antibody. Nucl. Med. Biol. 20, 617-623

3) Kobayashi H, Sakahara H, Saga T, Hosono M, Shirato M, Kanda H, Ishibashi K, Watanabe T, Endo K, Ishiwata I, and Konishi J (1993) A human/mouse chimeric monoclonal antibody against CA125 for radioimmunoimaging of ovarian cancer. Cancer Immunol. Immunother. 37, 143-149

4) Kobayashi H, Sakahara H, Hosono M, Shirato M, Konishi J, Takahashi J A, Oda Y, Kikuchi H, Endo K, Kozai Y, and Hatanaka M. (1993) Scintigraphic detection of xenografted tumors producing human basic fibroblast growth factor. Cancer Immunol. Immunother. 37, 281-285

5) 細野　真、小林久隆、白土　誠、阪原晴海、小西淳二、細野雅子、遠藤啓吾、上田龍三 (1993)　131I標識モノクローナル抗体による肺小細胞癌移植マウスの治療, 免疫核医学 8, 38-40

6) 小林久隆、阪原晴海、細野　真、白土　誠、小西淳二、近藤精二、宮武伸一、菊池晴彦、難波雄二郎、遠藤啓吾（1993）抗グリオーマ抗体による神経外胚葉由来の肺小細胞癌の画像診断、免疫核医学 8, 50-52

19）心臓血管外科学教室

1) Oda T, Miyamoto A.T, Okamoto Y, and Ban T. (1992) Skeletal muscle powered pumps can work under low preload - Design considerations -. Asaio Transactions Vol.38 No.3 M341-346

2) Oda T, Miyamoto A T, Okamoto Y, and Ban T. (1993) Skeletal muscle - powered ventricle. J. Thorac. Cardiovascu. Surg. Vol.105 No.1 p.66-77.

3) Oda T, Ban T, Okamoto Y, and Miyamoto A T. (1993) Dual chamber skeletal muscle - powered pump: Performance at low filling pressure. Artificial Heart 4 p.335-338, Akutsu T, and Koyanagi H (eds.). Springer - Verlog Tokyo.

4) 中山正吾、伴　敏彦、岡本好史 (1992) 凍結保存ヒト大動脈弁作製のための実験的研究.　日本心臓血管外科学会誌、（Vol.21 No.3）238-244

5) 織田禎二、腰地孝昭、宮本忠臣、岡本好史、伴　敏彦 (1993) DUAL CHAMBER SKELETAL MUSCLE VENTRICLE : 並列型と直列型の比較.　人工臓器、(Vol.22 No.3）、708-712

6) 織田禎二、宮本忠臣、岡本好史、伴　敏彦 (1993) 生理的前負荷駆動に適した新しい骨格筋ポンプの開発　−”二連銃”型骨格筋ポンプと従来型骨格筋ポンプの比較− 日本胸部外科学会誌、（Vol.41 No.3）、ｐ10（356）-16 （362）

7) 中山正吾、伴　敏彦、岡本好史 (1993)　凍結保存大動脈弁における線維芽細胞生存性の定量評価. 日本胸部外科学会誌、（Vol.41 No.8）ｐ.83（1357）-88（1362）

20）臨床検査医学教室

1) Sugawa H, Miyamoto M, Higuchi K, Smith E, Mori T, and Imura H. (1992) Production and properties of novel human thyroid cancer specific monoclonal antibodies. Biochemical and Biophysical Research Communications 187, 404-412

2) Sugawa H, Smith E, Imura H, and Mori T. (1993) A thyroid cancer specific monoclonal antibody which recognizes cryptic epitope(s) of human t hyroglobulin. Molecular and Cellular Endocrinology 93, 207-211

21）形成外科学教室

1) 長沢直子、松田和也、鈴木茂彦、石川浩三、一色信彦 (1993) 軟骨膜細胞の培養実験.　日形会誌、13、431-439

22）病態栄養部

1) Yasuda K, Yamada Y, Inagaki N, Yano H, Okamoto Y, Tsuji K, Fukumoto H, Imura H, Seino S, and Seino Y. (1992) Expression of GLUT 1 and GLUT 2 glucose transporter isoforms in rat islets of Langerhans and their regulation by glucose. Diabetes 41(1), 76-81

2) Imura H, Seino Y, and Kurose T. (1992) Mechanism of sympathetic neural regulation of insulin, somatostatin and glucagon secretion. In: Diabetes 1991, H Rifkin, J A Colwell and S I Taylor (eds), Elsevier Amsterdam p. 516-519

3) Tsuura Y, Ishida H, Okamoto Y, Tsuji K, Kurose T, Horie M, Imura H, Okada Y, and Seino Y. (1992) Impaired glucose sensitivity of ATP-sensitive K+ channels in pancreatic β cells in streptozotocin-induced NIDDM rats. Diabetes 41(7), 861-865

4) Kurose T, Tsuda K, Ishida H, Tsuji K, Okamoto Y, Tsuura Y, Kato S, Usami M, Imura H, and Seino Y. (1992) Glucagon, insulin and somatostatin secretion in response to sympathetic neural activation in streptozotocin-induced diabetic rats: A study with the isolated perfused rat pancreas in vitro. Diabetologia 35(11), 1035-1041

5) Tsuji K, Taminato T, Ishida H, Okamoto Y, Tsuura Y, Kato S, Kurose T, Seino Y, and Imura H. (1992) Cytoplasmic Ca2+ response in pancreatic β cells of NON mice. In: Current Concepts of a New Animal Model: The NON-mouse, Sakamoto N, Hotta N and Uchida K (eds). Elsevier Amsterdam p. 61-72

6) Okamoto Y, Ishida H, Tanimoto T, Tsuji K, Kurose T, Tsuura Y, Kato S, Imura H, and Seino Y. (1992) The role of cytosolic Ca2+ in impaired sensitivity to glucose of rat pancreatic islets exposed to high glucose in vitro. Diabetes 41(12), 1555-1561

7) Ishida H, Seino Y, Takeshita N, Kurose T, Tsuji K, Okamoto Y, Someya Y, Hara K, Akiyama Y, Imura H, and Nozawa M. (1992) Effect of pancreatic transplantation on decreased levels of circulating bone γ -carboxyglutamic acid-containing protein and osteopenia in streptozotocin-induced diabetes. Acta Endocrinol (Copenh) 127(1), 81-85

8) Someya Y, Yasuda K, Inagaki N, Yano H, Masuda K, Seino Y, and Imura H. (1993) Effects of glucose concentration on GLUT 1 and GLUT 2 mRNA levels in rat pancreatic islets. In: Prevention and Treatment of NIDDM, Goto Y, Lee Y H, Kaneko T, Shigeta Y (eds). Smith-Gordon, London, p. 11-12

9) Takeshita N, Ishida H, Yamamoto T, Koh G, Kurose T, Tsuji K, Okamoto Y, Ikeda.H, and Seino Y. (1993) Circulating levels and bone contents of bone γ-carboxyglutamic acid-containing protein in rat models of non-insulin-dependent diabetes mellitus. Acta Endocrinol (Copenh) 128(1), 69-73

10) X H Gu, Kurose T, Kato S, Masuda K, Tsuda K, Ishida H, and Seino Y. (1993) Suppressive effect of GABA on insulin secretion from the pancreatic beta-cell in the rat. Life Sci. 52(8), 687-694

11) Hayashi S, Horie M, Tsuura Y, Ishida H, Okada Y, Seino Y, and Sasayama S. (1993) Disopyramide blocks pancreatic ATP-sensitive K+ channels and enhances insulin release. Am. J. Physiol. 265(2), C337-C342

12) Tsuura Y, Ishida H, Okamoto Y, Kato S, Sakamoto K, Horie M, Ikeda H, Okada Y, and Seino Y. (1993) Glucose sensitivity of ATP-sensitive K+ channels is impaired in βcells of the GK rat, a new genetic model of NIDDM. Diabetes 42(10), 1446-1453

13) Tsuji K, Tanimoto T, Ishida H, Okamoto Y, Tsuura Y, Kato S, Kurose T, Okada Y, Imura H, and Seino Y. (1993) Selective impairment of the cytoplasmic Ca2+ response to glucose in rat pancreatic β-cells of streptozotocin-induced non-insulin-dependent diabetic rats. Metabolism 42(11),1424-1428

23）附属動物実験施設

1) Yasue M, Serikawa T, Kuramoto T, Mori M, Higashiguchi T, Ishizaki K, and Yamada J. (1992) Chromosomal assignments of 17 structural genes and 11 related DNA fragments in rats (Rattus norvegicus) by southern blot analysis of rat x mouse somatic cell hybrid clones. Genomics 12, 659-664

2) Mori M, Ishizaki K, Serikawa T, and Yamada J. (1992) Localization of the rat insulin I gene (INS1) to chromosome 1q55 by fluorescence in situ hybridization. Cytogenetics and Cell Genetics 59, 31-33

3) Mori M, Yokota Y, Yasue M, Serikawa T, and Yamada J. (1992) Assignment of the rat genes coding for substance P receptor, substance K receptor, and neuromedin K receptor to chromosomes 4, 20 and 2, respectively. Cytogenetics and Cell Genetics 60, 222-223

4) Serikawa T, Kuramoto T, Hilbert P, Mori M, Yamada J , Dubay C J, Lindpainter K, Ganten D, Guenet J L, Lathrop G M, and Beckmann J S. (1992) Rat gene mapping using PCR-analyzed microsatellites. Genetics 131, 701-721

5) Mori M, Oda T, Nishiyama K, Serikawa T, Yamada J, and Ichiyama A. (1992) A single serine: pyruvate aminotransferase gene on rat chromosome 9q34-36. Genomics 13, 686-689

6) Serikawa T, Montagutelli X, Chazottes D S, and Guenet J L. (1992) Polymorphisms revealed by PCR with single, short-sized, arbitrary primers are reliable markers for mouse and rat gene mapping. Mammalian Genome 3, 65-72

7) Mori M, Ishizaki K, Serikawa T, and Yamada J. (1992) Instability of the minisatellite sequence in the first intron of the rat renin gene and localization of the gene to chromosome 13q13 between FH and PEPC loci. Journal of Heredity 83, 204-207

8) Katsuya T, Higaki J, Miki T, Kohara K, Yagisawa H, Tanase H, Mikami H, Serikawa T, Nojimsa H, and Ogihara T. (1992) Hypotensive effect associated with a phospholipase C-d1 gene mutation in the spontaneously hypertensive rat. Biochemical and Biophysical Research Communications 187, 1359-1366

9) Sasa M, Ishihara K, Momiyama T, Renming X, Todo N, Amano T, Serikawa T, and Yamada J. (1992) Abnormal calcium current in hippocampal CA3 pyramidal cells of the spontaneously epileptic rat (SER). Japanese Journal of Psychiatry and Neurology 46, 526-528

10) Shirasaka Y, Ito M, Mikawa H, Serikawa T, and Yamada J. (1992) Alterations of benzodiazepine receptor binding in tremor rats with absence-like seizures. Journal of Neurochemistry 58, 2292-2295

11) Sadamatsu M, Kanai H, Masui A, Serikawa T, Yamada J, Sasa M, and Kato N. (1992) Changes of immunoreactive somatostatin, neuropeptide Y, and corticotropin-releasing factor (CRF) in the brain of spontaneously epileptic rats (SER). The Japanese Journal of Psychiatry and Neurology 46, 531-533

12) Renming X, Ishihara K, Sasa M, Ujihara H, Momiyama T, Fujita Y, Todo N, Serikawa T, Yamada J, and Takaori S. (1992) Antiepileptic effects of CNK-60A, a novel thyrotropin-releasing hormone analog, on absence-like and tonic seizures of spontaneously epileptic rats. European Journal of Pharmacology 223, 185-192

13) Sasa M, Ishihara K, Momiyama T, Renming X, Todo N, Amano T, Serikawa T, Yamada J. (1992) Abnormal calcium current in hippocampal CA3 pyramidal cells of the spontaneously epileptic rat (SER). The Japanese Journal of Psychiatry and Neurology 46(2), 526-528

14) Kondo Y, Yasue M, Serikawa T, and Yamada J. (1993) Genetic polymorphisms of salivary proteins in the rat. Experimental Animals 42(1), 83-88

15) Kuramoto T, Serikawa T, Hayasaka N, Mori M, and Yamada J. (1993) Regional mapping of the Rowett nude gene (RONU) to rat chromosome 10q24-q32 by localizing linked SYB2 and GH loci. Cytogenetics and Cell Genetics 63, 107-110

16) Hara M, Sasa M, Kawabata A, Serikawa T, Yamada T, Yamada J, and Takaori S. (1993) Decreased dopamine and increased noradrenaline levels in the spontaneously epileptic rat, a double mutant rat. Epilepsia 34 (3), 433-440

17) Saji H, Iida Y, Takahashi M, Sasa M, Serikawa T, and Yamada J, and Yokoyama A. (1993) Local cerebral glucose utilization in the interictal state of the spontaneously epileptic rat (SER). Brain Research 601, 76-79

18) Muramatsu Y, Yamada T, Agui T, Yamada J, Serikawa T, and Matsumoto K. (1993) Chromosomal assignments of genes for rat glutathione S-transferase Yb1 (GSTA3) and Yb2 (GSTA4) subunits. Cytogenetics and Cell Genetics 63, 141-143

19) Katsuya T, Higaki J, Zhao Y, Miki T, Mikami H, Serikawa T, and Ogihara T. (1993) A neuropeptide Y locus on chromosome 4 consegregates with blood pressure in the spontaneously hypertensive rat. Biochemical and Biophysical Research Communications 192 (1), 261-267

20) Kobayashi K, Kawashima K, Kawashima Y, Yamamura T, Kuse H, Asano Y , Kawai Y, Hori M, Okaniwa A, Serikawa T, and Yamada J. (1993) Retinal dopamine and its metabolite contents in zitter rats and spontaneously epileptic rats. Experimental Animals 42 (2), 249-250

21) Kishi K, Itoh M, Tsuda A, Tsuda H, Shiraishi H, Sejima H, Mori C, Serikawa T, and Yamada J. (1993) GABA-gated chloride ion influx in brains of tremor rats. Neurochemical Research 18 (9), 977-982

22) Kuramoto T, Mori M, Hirayama N, Saburi S, Yamada J, and Serikawa T. (1993) A strategy for rapid construction of genetic and physical maps in the rat. Acta Histochemica et Cytochemica 26 (4), 325-332

23) Mitsuyoshi I, Itoh M, Shirasaka Y, Mikawa H, Serikawa T, and Yamada J. (1993) Changes of NMDA receptor binding in spontaneously epileptic rat and parent strains. Neurochemical Reserch 18 (11), 1169-1173

24) Kondo Y, Mori M, Kuramoto T, Yamada J, Beckmann J S, Simon-Chazottes D, Montagutelli X, Guenet J.-L , and Serikawa T. (1993) DNA segments mapped by reciprocal use of microsatellite primers between mouse and rat. Mammalian Genome 4, 571-576