京都大学医学部附属動物実験施設報　第２号

動物実験施設利用者研究業績

（1994年〜1995年）

(1)生理系専攻 ( Physiology )

生体情報科学講座 ( Biological Sciences )
　 生体情報科学分野 ( Biological Sciences )

生体制御医学講座 ( Bioregulation )
　 循環生理学分野 ( Pharmacology )

(2)病理系専攻 ( Pathology )

基礎病態学講座 ( Basic Pathology )
　 病態生物医学分野 ( Pathology and Biology of Diseases )

感染・免疫学講座 ( Infectious Diseases and Immunology )
　 免疫細胞生物学分野 ( Immunology and Cell Biology )

(3)分子医学系専攻 ( Molecular Medicine )

分子生体統御学講座 ( Moleculer Biology )
　 分子生物学分野 ( Medical Chemistry )
　 分子細胞情報学分野 ( Cell Biology )

(4)脳統御医科学系専攻 ( Neuroscience )

高次脳科学講座 ( Basic Neuroscience )
　 神経・細胞薬理学分野 ( Cell Pharmacology )

(5)内科系専攻 ( Internal Medicine )

臨床病態医科学講座 ( Medicine and Clinical Science )
　 臨床病態医科学分野 ( Medicine and Clinical Science )

臨床器官病態学講座 ( Clinical Sciences for Pathological Organs )
　 皮膚病態学分野 ( Dermatology )

臨床生体統御医学講座 ( Clinical Bioregulation )
　 病態代謝栄養学分野 ( Metabolism and Clinical Nutrition )
　 臨床病態検査学分野 ( Laboratory Medicine )

発生発達医学講座 ( Developmental Medicine )
　 発達小児科学分野 ( Pediatrics )

放射線医学講座 ( Radiology and Nuclear Medicine )
　 腫瘍放射線科学分野 ( Therapeutic Radiology and Oncology )
　 核医学・画像診断学分野 ( Nuclear Medicine and Diagnostic Imaging )

(6)外科系専攻 ( Surgery )

器官外科学講座 ( Surgery for Visceral Organs )
　 消化器外科学分野 ( Gastroenterological Surgery )
　 婦人科学産科学分野 ( Gynecology and Obstetrics )
　 泌尿器病態学分野 ( Urology )
　 心臓血管外科学分野 ( Cardiovascular Surgery )
　 臨床病態生理学分野 ( Anesthesia )

感覚運動系病態学講座 ( Surgery for Sensory and Motor Systems )
　 筋・骨格系病態学分野 ( Orthopaedic and Musculoskeletal Surgery )
　 視覚病態学分野 ( Ophthalmology and Visual Science )
　 聴覚・言語病態学分野 ( Hearing and Speech Science )

(7)分子医学系専攻 ( Molecular Medicine )

遺伝医学講座 ( Medical Genetics )
　 腫瘍外科学分野 ( Surgery and Surgical Basic Science )

(8)脳統御医科学系専攻 ( Neuroscience )

脳病態生理学講座 ( Clinical Neuroscience )
　 脳神経外科学分野 ( Neurosurgery )

(9) 医学部附属動物実験施設 ( Institute of Laboratory Animals )

(1)生理系専攻 ( Physiology )

生体情報科学講座 ( Biological Sciences )

生体情報科学分野 ( Biological Sciences )

1) Masu, M., Iwakabe, H., Tagawa, Y., Miyoshi, T., Yamashita, M., Fukuda, Y., Sasaki, H., Hiroi, K., Nakamura, Y., Shigemoto, R., Takada, M., Nakamura, K., Nakao, K., Katsuki, M. and Nakanishi, S. (1995). Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene. Cell, 80, 757-765.

2) Ishibashi, M., Ang, S. L., Shiota, K., Nakanishi, S., Kageyama, R. and Guillemot, F. (1995). Targeted disruption of mammalian hairly and Enhancer of split holmolog-1(HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects. Genes & Dev., 9, 3136-3148.

生体制御医学講座 ( Bioregulation )

循環生理学分野 ( Pharmacology )

1) Enoki, T., Miwa, S., Sakamoto, A., Minowa, T., Komuro, T., Kobayashi, S., Ninomiya, H. and Masaki, T. (1995). Long-lasting activation of cation current by low concentration endothelin-1 in mouse fibroblasts and smooth muscle cells of rabbit aorta. Brit. J. Pharmacol., 115, 479-485.

(2)病理系専攻 ( Pathology )

基礎病態学講座 ( Basic Pathology )

病態生物医学分野 ( Pathology and Biology of Diseases )

1) Nishiyama, Y., Suwa, H., Okamoto, K., Fukumoto, M., Hiai, H. and Toyokuni, S. (1995). Low incidence of point mutations in H-, K- and N-ras oncogenes and p53 tumor suppressor gene in renal cell carcinoma and peritoneal mesothelioma of Wistar rats induced by ferric nitrilotriacetate. Jpn. J. Cancer Res., 86, 1150-1158.　　　　

2) Liang, P., Kitada, K., Osaka, M., Serikawa, T., Takahashi, R., Yamada, Y., Hiai, H. and Sugiyama, T. (1995). Chromosomal localization of the rat erythropoietin receptor gene by fluorescence in situ hybridization. Jpn. J. Genetics, 70, 525-531.

3) Nishimura, M., Hirayama, N., Serikawa, T., , Kanehira, K., Matsushima, Y., Katoh, H., Wakana, S., Kojima, A. and Hiai, H. (1995). The SMXA: A new set of recombinant strains of mice consisting of 26 substrains and their genetic profile. Mammal. Genome, 6, 850-857.

4) Okamoto, K., Yamada, Y., Shimada, M. O., Nakakuki, Y., Nomura, H. and Hiai, H. (1994). Abnormal bone marrow B-cell differentiation in pre-B lymphoma-prone SL/Kh mice. Cancer Res., 54, 399-402.

5) Yamada, Y., Shimada, M. O., Toyokuni, S., Okamoto, K., Fukumoto, M. and Hiai, H. (1994). Genetic susceptibility to pre-B lymphoma in SL/Kh strain mice. Cancer Res., 54, 403-407.

6) Toyokuni, S., Uchida, K., Okamoto, K., Nakakuki, Y., Hiai, H. and Stadtman, E. R. (1994). Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcionogen, ferric nitrilotriacetate. Proc. Natl. Acad. Sci. USA, 91, 2616-2620.

7) Hattori-Nakakuki, Y., Nishigori, C., Okamoto, K., Imamura, S., Hiai, H. and Toyokuni, S. (1994). Formation of 8-hydroxy-2'-deoxyguanosine in epidermis of hairless mice exposed to near UV. Biochem. Biophys. Res. Comm., 201, 1132-1139.

8) Yamada, Y., Shisa, H., Matsushiro, H., Lu, L. M., Kawarai, A. and Hiai, H. (1994). T-lymphomagenesis is determined by a dominant host gene Thymic Lymphoma Susceptible Mouse-1 (Tlsm-1) in murine models. J. Exp. Med., 180, 2155-2162.

9) Miyake, N., Sawada, M. and Hiai, H. (1994). Purification and immunohistochemistry of a dithizone-sensitive 40 KDa zinc-binding protein in rat small intestine. Acta Histochem. Cytochem., 27, 335-341.

感染・免疫学講座 ( Infectious Diseases and Immunology )

免疫細胞生物学分野 ( Immunology and Cell Biology )

1) Kubota, H., Sato, M., Ogawa, Y., Iwai, K., Hattori, M., Yoshida, T. and Minato, N. (1994). Involvement of 4F2 antigen expressed on the MHC-negative target cells in the recognition of murine CD3+CD4-CD8-αβ ( Vα4 /Vβ2 ) T cells. Int. Immunol., 6, 1323-1331.

2) Sato, M., Okazaki, H., Okamoto, H., Ohtaka, A., Shimizu, H., Minato, N. and Kano, S. (1994). Pulmonary hypertension in Systemic lupus erythematosus: a report of an autopsied case. Internal Medicine, 33, 540-542.

3) Hattori, M., Tsukamoto, N., Nur-E-Kamal, M. S. A., Rubinfeld, B., Iwai, K., Kubota, H., Maruta, H. and Minato, N. (1995). Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression. Mol. Cell. Biol., 15, 552-560.

4) Tanigawa, T., Araki, S., Araki, T., Minato, N. and Yokoyama, K. (1995). Decreases of CD4- and CD8-positive T lymphocytes in retired chromate workers. Am. J. Ind. Med., 27, 877-882.

5) 湊　長博 (1994). 臓器特異的リンパ球とは？ Molecular Medicine, 31(4), 384-386.

6) 服部雅一、湊　長博 (1994). リンパ系細胞に強く発現される核内 GTPase 活性化蛋白の遺伝子とその機能.　Immunology Frontier, 4(6), 33-36.

7) 湊　長博 (1994). 各種キラー細胞による抗原の認識.　実験医学, 12(17), 114-119.

8) 久保田浩司、湊　長博 (1994). 胸腺外におけるＴ細胞の分化と選択. 日本臨床, 52(11), 11-16.

(3)分子医学系専攻 ( Molecular Medicine )

分子生体統御学講座 ( Moleculer Biology )

分子生物学分野 ( Medical Chemistry )

1) Nisitani, S., Tsubata, T. and Honjo, T. (1994). Lineage marker-negative lymphocyte precursors derived from embryonic stem cells in vitro differentiate into mature lymphocytes in vivo. Int. Immunol., 6, 909-916.

2) Murakami, M., Tsubata, T., Shinkura, R., Nisitani, S., Okamoto, M., Yoshioka, H., Usui, T., Miyawaki, S. and Honjo, T. (1994). Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse. J. Exp. Med., 180, 111-121.

3) Asano, M., Ishida, Y., Sabe, H., Kondo, M., Sugamura, K. and Honjo, T. (1994). Interleukin-2 can support growth of CD8+ T cells but not CD4+ T cells of human IL-2 receptor βchain transgenic mice. J. Immunol., 153, 5373-5381.

4) Murakami, M., Yoshioka, H., Shirai, T., Tsubata, T. and Honjo, T. (1995). Prevention of autoimmune symptoms in autoimmune-prone mice by elimination of B-1 cells. Int. Immunol., 7, 877-882.

5) Oka, C., Nakano, T., Wakeham, A., Mori, C., Sakai, T., Okazaki, S., Kawaichi, M., Shirota, K., Mak, T. and Honjo, T. (1995). Disruption of the mouse RBP-Jk gene results in early embryonic death. Development, 121, 3291-3301.

6) Nisitani, S., Tsubata, T., Murakami, M. and Honjo, T. (1995). Administration of interleukin 5 or 10 activates peritoneal B-1 cells and induces autoimmune hemolytic anemia in anti-erythrocyte autoantibody transgenic mice. T. Eur. J. Immunol., 25, 3047-3052.

分子細胞情報学分野 ( Cell Biology )

1) Kishino, T., Ariga, T., Soejima, H., Tamura, T., Ohta, T., Jinno, Y., Yonemura, S., Sato, N., Tsukita, S., Tsukita, S., Sakiyama, Y. and Niikawa, N. (1994). Assignment of the human moesin gene (MSN) to chromosome region Xq11.2-q12. Cytogenet. Cell Genet., 66, 167-169.

2) Ochiai, A., Akimoto, S., Shimoyama, Y., Nagafuchi, A., Tsukita, S. and Hirohashi, S. (1994). Selective loss of alpha-catenin expression in scirrhous carcinomas with scattered cell growth. Jap. J. Cancer Res., 85, 266-273.

3) Shiozaki, H., Iihara, K., Oka, H., Kadowaki, T., Matsui, S., Gofuku, J., Inoue, M., Nagafuchi, A., Tsukita, S. and Mori, T. (1994). Immunohistochemical detection of alpha-catenin expression in human cancers. Am. J. Pathol., 144, 667-674.

4) Takeuchi, K., Sato, N., Kasahara, H., Funayama, N., Nagafuchi, A., Yonemura, S., Tsukita, S. and Tsukita, S. (1994). Perturbation of cell adhesion and microvilli formation by antisense oligonuclotides to ERM family members. J. Cell Biol., 125, 1371-1384.

5) Takeuchi, K., Sato, N., Kasahara, H., Funayama, N., Nagafuchi, A., Yonemura, S., Tsukita, S. and Tsukita, S. (1994). Perturbation of cell adhesion and microvilli formation by antisense oligonuclotides to ERM family members. J. Cell Biol., 125, 1371-1384.

6) Takeuchi, K., Kawashima, A., Nagafuchi, A. and Tsukita, S. (1994). Perturbation of cell adhesion and microvilli formation by antisense oligonuclotides to ERM family members. J. Cell Sci., 107, 1921-1928.

7) Tsukita, S., Oishi, K., Sato, N., Sagara, J., Kawai, A. and Tsukita, S. (1994). ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons. J. Cell Biol., 126, 391-401.

9) Nagafuchi, A., Ishihara, S. and Tsukita, S. (1994). The roles of catenins in the cadherin-mediated cell adhesion: Functional analysis of E-cadherin-alpha catenin fusion molecules. J. Cell Biol., 127, 235-245.

10) Kasahara, H., Itoh, M., Sugiyama, T., Kido, N., Hayashi,H., Saito, H., Tsukita, S. and Kato, N. (1994). Autoimmune myocarditis induced in mice by c-protein. J. Clin. Invest., 94, 1026-1036.

11) Matsui, S., Shiozaki, H., Inoue, M., Tamura, S., Doki, Y., Kadowaki, T., Iwazawa, T., Shimaya, K., Nagafuchi, A., Tsukita, S. and Mori, T. (1994). Immunohistochemical evaluation of alpha-catenin expression in human gastric cancer. Virchows Archiv, 424, 375-381.

12) Tsukita, S., Tsukita, S., Nagafuchi, A. and Yonemura, S. (1994). Molecular organization of the plaque structure of cadherin-based cell-to-cell adherens junctions andits possible involvement in tumorigenesis and metastasis. 1994 In Molecular Mechanisms of Epithelial Cell Junctions: From Development to Disease, 217-228.

13) Furuse, M., Itoh, M., Hirase, T., Nagafuchi, A., Yonemura, S., Tsukita, S. and Tsukita, S. (1994). Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions. J. Cell Biol., 127, 1617-1626.

14) Oyama, T., Kanai, Y., Ochiai, A., Akimoto, S., Oda, T., Yangihara, K., Nagafuchi, A., Tsukita, S., Shibamoto, S., Ito, F., Takeichi, M., Matsuda, H. and Hirohashi, S. (1994). A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: A cause of loss of intercellular adhesiveness in human cancer cell lines. Cancer Res., 54, 6282-6287.

15) Yonemura, S., Itoh, M., Nagafuchi, A. and Tsukita, S. (1995). Cell-to-cell adherens junction formation and actin filament organization: Similarities and difference between non-polarized fibroblasts and polarized epithelial cells. J. Cell Sci., 108, 127-142.

16) Sagara, J., Tsukita, S., Yonemura, S., Tsukita, S. and Kawai, A. (1995). Cellular actin-binding ezrin-radixin-moesin (ERM) family proteins are incorporated into the rabies virion and closely associated with viral envelope proteins in the cell. Virology, 206, 485-494.

17) Takaishi, K., Sasaki, T., Kameyama, T., Tsukita, S., Tsukita, S. and Takai, Y. (1995). Translocation of activated Rho from the cytoplasm to membrane ruffling area, cell-cell adhesion sites, and cleavage furrows. Oncogene, 11, 39-48.

18) Yasui, W., Kuniyasu, H., Akama, Y., Kitahara, K., Nagafuchi, A., Ishihara, S., Tsukita, S. and Tahara, E. (1995). Expression of E-cadherin, alpha-and beta-cateninsin human gastric carcinomas: Correlation with histology and tumor progression. Oncology Res., 2, 111-117.

19) Oyama, T., Knai, Y., Ochiai, A., Akimoto, S., Oda, T., Yanagihara, K., Nagafuchi, A., Tsukita, S., Shibamoto, S., Ito, F., Takeichi, M., Matsuda, H. and Hirohashi, S. (1995). A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: A cause of loss of intercellular adhesiveness in human cancer cell lines. Cancer Res., 54, 6282-6287.

20) Takeda, H. and Tsukita, S. (1995). Effects of tyrosine phosphorylation on tight junctions in temperature-sensitive v-src-transfected MDCK cells. Cell Struct. Funct., 20, 387-393.

21) Takeda, H., Nagafuchi, A., Yonemura, S., Tsukita, S., Behrens, J., Birchimeier, W. and Tsukita, S. (1995). V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta-catenin is not required for the shift. J. Cell Biol., 131, 1839-1847.

(4)脳統御医科学系専攻 ( Neuroscience )

高次脳科学講座 ( Basic Neuroscience )

神経・細胞薬理学分野 ( Cell Pharmacology )

1) Ushikubi, F., Nakamura, K. and Narumiya, S. (1994). Functional reconstitution of platelet thromboxane A2 receptors with Gq and Gi2 in phospholipid vesicles. Molecular Pharmacology, 46, 808-816.

(5)内科系専攻 ( Internal Medicine )

臨床病態医科学講座 ( Medicine and Clinical Science )

臨床病態医科学分野 ( Medicine and Clinical Science )

1) Hama, N., Itoh, H., Shirakami, G., Suga, S., Komatsu, Y., Yoshimasa, T., Tanaka, I., Mori, K. and Nakao, K. (1994). Detection of C-type natriuretic peptide (CNP) in human circulation and marked increase of plasma CNP level in septic shock patients. Biochem. Biophys. Res. Commun., 198, 1177- 1182.

2) Ogawa, Y., Itoh, H., Tamura, N., Suga, S., Yoshimasa, T., Uehira, M., Matsuda, S., Shiono, S., Nishimoto, H. and Nakao, K. (1994). Molecular cloning of the cDNA and gene encoding mouse brain natriuretic peptide and generation of transgenic mice that overexpress the brain natriuretic peptide gene. J. Clin. Invest., 93, 1911-1921.

3) Inenaga, K., Nagatomo, T., Nakao, K., Yanaihara, N. and Yamashita, H. (1994). Kappa-selective agonists decrease postsynaptic potentials and calcium components of action potentials in the supraoptic nucleus of rat hypothalamus in vitro. Neurosci., 58, 331-340.

4) Okazaki, T., Ozaki, S. and Nakao, K. (1994). CD4+ T Cells require adhesion via LFA-1 / ICAM-1 to induce target apoptosis in TNF-independent pathway. Cell Immunol., 156, 135-145.

5) Tamura, N., Ogawa, Y., Itoh, H., Arai, H., Suga, S., Nakagawa, O., Komatsu, Y., Kishimoto, I., Takaya, K., Yoshimasa, T., Shiono, S. and Nakao, K. (1994). Molecular cloning of hamster brain and atrial natriuretic peptide cDNAs --- Cardiomyopathic hamsters are useful models for brain and atrial natriuretic peptides ---. J. Clin. Invest., 94, 1059-1068.

6) Kita, M., Taii, S., Kataoka, N., Shimatsu, A., Nakao, K. and Mori, T. (1994). Changes of gonadotrophin surge inhibiting / attenuating factor activity in porcine follicular fluid in relation to follicular size. J. Reprod. fertil., 101, 59-66.

7) Sakamoto, A., Yanagisawa, M., Tsujimoto, G., Nakao, K., Toyo-oka T. and Masaki, T. (1994). Pseudo-noncompetitive antagonism by BQ123 of intracellular calcium transients mediated by human ETA endothelin receptor. Biochem. Biophys. Res. Commun., 200, 679-686.

8) Sando, T., Usui, T., Tanaka, I., Mori, K., Sasaki, Y., Fukuda, Y., Namba, T., Sugimoto, Y., Ichikawa, A., Narumiya, S. and Nakao, K. (1994). Molecular cloning and expression of rat prostaglandin E receptor EP subtype. Biochem. Biophys. Res. Commun., 200, 1329-1333.

9) Hashimoto, Y., Nakao, K., Hama, N., Imura, H., Mori, S., Yamaguchi, M., Yasuhara, M. and Hori, R. (1994). Clearance mechanisms of atrial and brain natriuretic peptides in rats. Pharm. Res., 11, 60-64.

10) Nishimura, T., Mizukawa, K., Nakao, K., Yamada, H., Kinoshita, M. and Ochi, J. (1994). Atrial natriuretic polypeptide (ANP) -immunoreactivity and specific atrial granules in cardiac myocytes of stroke-prone spontaneously hypertensive rat (SHRSP). Arch. Histol. Cytol., 57, 1-7.

11) Hasegawa, K., Fujiwara, H., Doyama, K., Inada, T., Ohtani, S., Fujiwara, T., Hosoda, K., Nakao, K. and Sasayama, S. (1994). Endothelin-1-selective receptor in the arterial intima of patients with hypertension. Hypertension, 23, 288-293.

12) Masuzaki, H., Jingami, H., Yamamoto, T. and Nakao, K. (1994). Effects of estradiol on very low density lipoprotein receptor mRNA levels in rabbit heart. FEBS Lett., 347, 211-214.

14) Hama, N., Itoh, H., Suga, S., Komatsu, Y., Yoshimasa, T. and Nakao, K. (1994). A monoclonal antibody to C-type natriuretic peptide - Preparation and application to radioimmunoassay and neutralization experiment. J. Endocrinol., in press.

15) Itoh, H., Sagawa, N., Hasegawa, M., Inamori, K., Hinohisa, N., Kitagawa, K., Nannno, H., Ihara, Y., Kobayashi, F., Mori, T., Suga, S., Yoshimasa, T., Itoh, H. and Nakao, K. (1994). Transforming growth factor-b stimulates, and glucocorticoids and epidermal growth factor inhibit brain natriuretic peptide secretion from cultured human amnion cells. J. Clin. Endocrinol. Metab., 79, 176-182.

16) Nakagawa, O., Tanaka, I., Usui, T., Harada, M., Sasaki, Y., Itoh, H., Yoshimasa, T., Namba, T. Narumiya, S. and Nakao, K. (1994). Molecular cloning of human prostacyclin receptor cDNA and its gene expression in cardiovascular system. Circulation, 90, 1643-1647.

17) Yasue, H., Yoshimura, M., Sumida, H., Kikuta,K., Kugiyama, K., Jougasaki, M., Ogawa, H., Okumura, K., Mukoyama, M. and Nakao, K. (1994). Localization and mechanism of secretion of B-type natriuretic peptide in comparison with thoseof A-type natriuretic peptide in normal subjects and patients with heart failure. Circulation, 90, 195-203.

18) Kato, H., Yasue, H., Yoshimura, M., Jougasaki, M., Tanaka, H., Miyano Y. and Nakao, K. (1994). Suppression of hyperventilation - induced attack with infusion of brain natriuretic peptide in patients with variant angina. Am. Heart. J., in press.

19) Yoshimura, M., Yasue. H., Tanaka, H., Kikuta, K., Sumida, H., Kato, H., Jougasaki M. and Nakao, K. (1994). Responses of plasma levels of A-type natriuretic peptide and B-type natriuretic peptide to alacepril, an angiotensin-converting enzyme inhibitor in patients with congestive heart failure. British Heart Journal, 72, 528-533.

20) Yoshimura, T., Yoshimura, M., Yasue, H., Ito, M., Okamura, H., Mukoyama, M. and Nakao, K. (1994). Plasma concentration of atrial natriuretic peptide and brain natriuretic peptide during normal human pregnancy and the postpartum period. J. Endocri., 140, 393-397.

21) Nishida, N., Fukuda, Y., Komeda, T., Kita, R., Sando, T., Furukawa, M., Amenomori, M., Shibagaki, I., Nakao, K., Ikenaga, M. and Ishizaki, K. (1994). Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma. Cancer Res., 54, 3107-3110.

22) Shirakami, G., Magaribuchi, T., Shingu, K., Kim, S., Saito, Y., Nakao, K. and Mori, K. (1994). Changes of endothelin concentration in cerebrospinal fluid and plasma of patients with aneurysmal subarachnoid hemorrhage. Acta Anaesthesiol. Scand., 38, 457-461.

23) Miyoshi, Y., Nakamura, H., Tagami, T., Sasaki S. and Nakao, K. (1994). 3,5,3' -Triiodothyronine stimulates retinoic acid-induced differentiation in HL-60 cells. Mol. Cell Endocrinol., 103, 119-123.

24) Furuto-kato, S., Shimatsu, A., Kuzuya, H., Matsuda, K., Nakao, K. and Imura, H. (1994). Insulin sensitivity and glycemic control before and after parathyroidectomy in a diabetic patient with familial multiple endocrine neoplasia type 1. Encocrine Journal, 41, 731-735.

25) Shirakami, G., Shingu, K., Tamai, S., Ando, A., Suga, S., Nakao K. and Mori, K. (1994). A case of " stunned myocardium " after noncardiac surgery: increased concentration of plasma brain natriuretic peptide. Anesth. Analg., 79, 175-179.

26) Ebisui, O., Fukata, J., Murakami, N., Kobayashi, H., Segawa, H., Muro, S., Hanaoka, I., Naito, Y., Masui, Y., Ohmoto, Y., Imura, H. and Nakao, K. (1994). Effect of IL-1 receptor antagonist and antiserum to TNF-αon LPS-induced plasma ACTH and corticosterone rise in rats. Am. J. Physiol., 266, E986-E992.

27) Ogawa, Y., Itoh, H., Yoshitake, Y., Inoue, M., Yoshimasa, T., Serikawa, T. and Nakao, K. (1994). Molecular cloning, and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc) : Comparison with the human CNP gene (NPPC). Genomics, 24, 383-387.

28) Yasuhara, M., Yamaguchi, M., Shimizu, H., Hashimoto, Y., Hama, N., Itoh, H., Nakao, K. and Hori, R. (1994). Natriuretic peptide-potentiating actions of neutral endopeptidase inhibition in rats with experimental heart failure. Pharmaceutical Research, 11, 1726-1730.

29) Okumura, K., Yasue, H., Fujii, H., Kugiyama, K., Matsuyama, K., Yoshimura, M., Jougasaki, M., Kikuta, K., Kato, H., Tanaka, H., Sumida, H. and Nakao, K. (1994). Effects of brain (B-type) natriuretic peptide on coronary artery diameter and coronary hemodynamics in humans: comparison with those on systemic hemodynamics. J. A. C. C., in press.

30) Hashimoto, Y., Ozaki, J., Yasuhara, M., Hori, R.. Suga, S.. Itoh, H., Nakao. K. and Inui, K. (1994). Functional evidence for an apical ANP receptor in LLC-PK1 kidney epithelial cells. Eur. J. Pharm.-Molec. Ph., 268, 443-445.

31) Itoh, H., Sagawa, N., Hasegawa, M., Nanno, H., Kobayashi, F., Ihara, Y., Mori, T., Komatsu, Y., Suga, S., Yoshimasa, T., Itoh, H. and Nakao, K. (1994). Expression of biologically active receptors for natriuretic peptides in the human uterus during pregnancy. Biochem. Bioph. Res. Commun., 203, 602-607.

32) Ogawa, Y., Itoh, H. and Nakao, K. (1994). Molecular biology of brain natriuretic peptide. Jpn. Heart J., 35, 496-497.

33) Nakao, K., Itoh, H., Yoshimasa, T. and Imura, H. (1994). C-type natriuretic peptide (CNP) as a novel endothelium-derived relaxing peptide: occurrence of vascular natriuretic peptide system. Elsevier Science, 123-129.

34) Kono, S., Kuzuya, H., Yamada, K., Yoshimasa, Y., Okamoto, M., Inoue, G., Hayashi, T., Suga, J., Imura, H. and Nakao, K. (1994). A novel substrate fot insulin-sensitive serine / threonine kinase in intact cells. Endocrinology, 135, 1529-1536.

35) Kishimoto, I., Yoshimasa, T., Suga, S., Ogawa, Y., Komatsu, Y., Nakagawa, O., Itoh, H. and Nakao, K. (1994). Natriuretic peptide clearance receptor is transcriptionally down-regulated by b2-adrenergic stimulation in vascular smooth muscle cells. J. Biol. Chem., 269, 28300-28308.

36) Sasaki, Y., Takahashi, T., Katakami, H., Tsuyuoka, R., Tanaka, K., Shigeno, C., Ishida, H., Nakamura, K., Kozuki, M., Okada, H. and Nakao, K. (1994). Hypercalcemia mediated by parathyroid hormone-related protein in chronic myeloid leukemia. Am. J. Hematol., 46, 251-252.

37) Tsuyuoka, R., Takahashi, T., Sasaki, Y., Taniguchi, Y., Fukumoto, M., Suzuki, A., Nakamura, K., Kobayashi, S., Kudo, T. and Nakao, K. (1994). Colony-stimulating factor-producing tumours : production of granulocyte colony-stimulating factor and interleukin-6 is secondary to interleukin-1 production. Eur. J.Cancer, 30, 2130-2136.

38) Sasaki, Y., Usui, T., Tanaka, I., Nakagawa, O., Sando, T., Takahashi, T., Namba, T., Narumiya, S. and Nakao, K. (1994). Cloning and expression of a cDNA for rat prostacyclin receptor. Biochim. Biophys. Acta, 1224, 601-605.

39) Nakao, K. (1994). C-type natriuretic peptide (CNP) as a novel endothelium-derived relaxing peptide. Microcirculation annual 1994 Vol. 10, edited by M. Tsuchiya, M. Asano and T. Ohhashi, Nihon-Igakukan, Tokyo, 29-30.

40) Puffenberger, E. G., Hosoda, K., Washington, S., Nakao, K., deWit, D., Yanagisawa, M. and Chakravarti, A. (1994). A missense mutation of the endothelin - B receptor gene in multigenic hirschsprung's disease. Cell, 79, 1257-1266.

41) Natsuii, K., Shigeno, C., Kohno, H., Yamamoto, T., Kasai, R., Tanaka, K., Yamamuro, T., Nakao, K. and Konishi, J. (1994). A high abundance of PTH-related protein in human cerebrospinal fluid. J. Bone Miner Met., 12, 207-209.

42) Sagawa, N., Hasegawa, M., Itoh, H., Nanno, H., Mori, T., Yano, J., Yoshimasa, T. and Nakao, K. (1994). The role of amniotic endothelin in human pregnancy. Placenta, 15, 565-575.

43) Ogawa, Y., Itoh, H., Nakagawa, O., Shirakami, G., Tamura, N., Yoshimasa, T., Nagata, K., Yoshida, N. and Nakao, K. (1995). Characterization of the 5'-flanking region and chromosomal assignment of the human brain natriuretic peptide gene. J. Mol. Med. 73, 457-463.

44) Tsuyuoka, R., Takahashi, T., Sasaki, Y., Nakamura, K., Fukumoto, M., Kurisu, Y., Tsubakimori, K., Shioi, K. and Nakao, K. (1995). Long term complete remission in primary plasma cell leukemia. Internal Medicine, 34, 251-254.

45) Tsuyuoka, R., Takahashi, T., Suzuki, A., Sasaki, Y., Nakamura, K., Fukumoto, M., Ohmori, K., Ohono, Y. and Nakao, K. (1995). A newly established megakaryoblastic / erythroid cell line differentiates to red cells in the presence of erythropoietin and produces platelet-like particles. Stem Cells, 13, 54-56.

46) Mashima, S., Shirakami, G., Mitsuyoshi, A., Nakagami, M., Morimoto, T., Terasaki, M., Nakao, K., Yamabe, H., Yamaoka, Y. and Ozawa, K. (1995). Evaluation of the protective effect of a novel PGI2 analog on mesenteric circulation following. European Surgical Research, in press.

47) Ozaki, S., Okazaki, T. and Nakao, K. (1995). Biological response modifier (BRM) as an antigen. III. T-cell lines specific for BRM kill tumor cells in a BRM-specific manner. Cancer Immunol. Immun., 40, 219-227.

48) Komeda, T., Fukuda, Y., Sando, T., Kita, R., Furukawa, M., Nishida, N., Amenomori, M. and Nakao, K. (1995). Sensitive detection of circulating hepatocellular carcinoma cells in peripheral venous blood. Cancer, 75, 2214-2219.

49) Suda, T., Okazaki, T., Naito, Y., Yokota, T., Arai, N., Ozaki, S., Nakao, K. and Nagata, S. (1995). Expression of the fas ligand in cells of T-cell-lineage. J. Immunol., 154, 3806-3813.

50) Sumida, H., Yasue, H., Yoshimura, M., Okumura, K., Ogawa, H., Kugiyama, K., Matsuyama, K., Kikuta, K., Morita, E. and Nakao, K. (1995). Comparison of secretion pattern between A-type natriuretic peptide and B-type natriuretic peptide in patients with old myocardial infarction. J. Am. Coll. Cardiol., 25, 1105-1110.

51) Ogawa, Y., Itoh, H. and Nakao, K. (1995). Molecular biology and biochemistry of natriuretic peptide family. Clin. Exp. Pharmacol. Physiol., 22, 49-53.

52) Shirakami, G., Magaribuchi, T., Shingu, K., Saito, Y., O'higashi, T., Nakao, K. and Mori, K. (1995). Effects of anesthesia and surgery on plasma endothelin levels. Anesth. Analg., 80, 449-453.

53) Ogawa, Y. and Nakao, K. (1995). Brain natriuretic peptide as a cardiac hormone in cardiovascular disorders. Hypertension : Pathophysiology, Diagnosis, and Management. 2nd Edition, edited by J. H. Laragh and B. M. Brenner, Raven Press, Ltd., New York, 833-840.

54) Ogawa, Y., Tanaka, I., Inoue, M., Yoshitake, Y., Isse, N., Nakagawa, O., Usui, T., Itoh, H., Yoshimasa, T., Narumiya, S. and Nakao, K. (1995). Structural organization, and choromosomal assignment of the human prostacyclin receptor gene. Genomics, 27, 142-148.

55) Okumura, K., Yasue, H., Fujii, H., Kugiyama, K., Matsuyama, K., Yoshimura, M., Jougasaki, M., Kikura, K., Kato, H., Tanaka, H., Sumida, H. and Nakao, K. (1995). Effects of brain (B-type) natriuretic peptide on coronary artery diameter and coronary hemodynamic variables in humans: comparison with effects on systemic hemodynamic variables. J. Am. Coll. Cardiol. 25, 342-348.

56) Koshiyama, H., Sone, T. and Nakao, K. (1995). Vitamin-D-receptor-gene polymorphism and bone loss. Lancet, 345, 990-991.

57) Ota, H., Kumagai, S., Morinobu, A., Yanagida, H. and Nakao, K. (1995). Enchanced production of transforming growth factor-beta (TGF-b) during autologous mixed lymphocyte reaction of systemic sclerosis patients. Clin. Exp. Immunol., 100, 99-103.

58) Nakagawa, O., Sasaki, Y., Tanaka, I., Usui, T., Sando, T., Muro, S., Mori, K., Itoh, H., Yoshimasa, T., Narumiya, S. and Nakao, K. (1995). Gene expression of prostacyclin receptor in the hypertrophied heart of spontaneously hypertensive rats. Clin. Exp. Pharmacol. Physiol., (Suppl.1), S270-S272.

59) Nakagawa, O., Itoh, H., Harada, M., Komatsu, Y., Yoshimasa, T. and Nakao, K. (1995). Gene regulation of brain natriuretic peptide in cardiocyte hypertrophy by a1-adrenergic stimulation. Clin. Exp. Pharmacol. Physiol., (Suppl.1), S183-185.

60) Nakagawa, O., Ogawa, Y., Itoh, H., Suga, S., Komatsu, Y., Kishimoto, I., Nishino, K., Yoshimasa, T. and Nakao, K. (1995). Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide in cardiocyte hypertrophy --Evidence for brain natriuretic peptide as an " emergency" cardiac hormone against ventricular overload--. J. Clin. Invest., 96, 1280-1287.

61) Masuzaki, H., Ogawa, Y., Shigemoto, M., Satoh, N., Mori, K., Tamura, N., Hosoda, K., Yoshimasa, Y., Jingami H. and Nakao, K. (1995). Adipose tissue-specific expression of the obese (ob ) gene in rats and its marked augmentation in genetically obese-hyperglycemic wistar fatty rats. Proc. Jpn. Acad., 71, 148-152.

62) Masuzaki, H., Ogawa, Y., Isse, N., Satoh, N., Okazaki, T., Shigemoto, M., Mori, K., Tamura, N., Hosoda, K., Yoshimasa, Y., Jingami, H., Kawada, T. and Nakao, K. (1995). The human obese gene expression -- adipocyte-specific expression and regional differences in the adipose tissue--. Diabetes, 44, 855-858.

63) Ogawa, Y., Masuzaki, H., Isse, N., Okazaki, T., Mori, K., Shigemoto, M., Satoh, N., Tamura, N., Hosoda, K., Yoshimasa, Y., Jingami, H., Kawada, T. and Nakao, K. (1995). Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese zucker fatty (fa/fa ) rats. J. Clin. Invest. 96, 1647-1652.

64) Kotani, M., Tanaka, I., Ogawa, Y., Usui, T., Mori, K., Ichikawa, A., Narumiya, S., Yoshimi, T. and Nakao, K. (1995). Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative mRNA splicing - Multiple second messenger systems and tissue-specific distributions -. Mol. Pharmacol., 48, 869-879.

65) Masuzaki, H., Ogawa, Y., Hosoda, K., Kawada, T., Fushiki, T. and Nakao, K. (1995). Augumented expression of the obese gene in the adipose tissue from rats fed high-fat diet. Biochem. Biophys. Res. Commun., 216, 355-358.

66) Takahashi, C., Kumagai, S., Tsubata, R., Sorachi, K., Ozaki, S., Imura, H. and Nakao, K. (1995). Case report portal hypertension associated with anticardiolipin antibodies in a case of systemic lupus erythematosus. Lupus, 4, 232-235.

67) Isse, N., Ogawa, Y., Tamura, N., Masuzaki, H., Mori, K., Okazaki, T., Satoh, N., Shigemoto, M., Yoshimasa, Y., Nishi, S., Hosoda, K., Inazawa, J. and Nakao, K. (1995). Structual organization and chromosomal assignment of the human obese gene. J. Biol. Chem., 270, 27728-27733.

68) Hama, N., Itoh, H., Shirakami, G., Nakagawa, O., Suga S., Ogawa, Y., Masuda, I., Nakanishi, K., Yoshimasa, T., Hashimoto, Y., Yamaguchi, M., Yasue, Y. and Nakao, K. (1995). Rapid ventriculae induction of brain natriuretic gene expression in experimental acute myocardial infarction. Circulation, 92, 1558-1564.

69) Igaki, T., Itoh, H., Suga, S., Hama, N., Ogawa, Y., Komatsu, Y., Mukoyama, M., Sugawara, A., Yoshimasa, T., Tanaka, I. and Nakao, K. (1995). C-type natriuretic peptide in chronic renal failure and its action in humans. Kidney Int., in press.

70) Yamashita, J., Yoshimasa, T., Arai, H., Hiraoka, J., Takaya, K., Miyamoto, Y., Ogawa, Y., Itoh, H. and Nakao, K. (1995). Cis elements for transcriptional regulation of the human endothelin-A receptor gene. J. Cardiovasc. Pharmacol., 26, (Suppl.), S26-S28.

71) Miyamoto, Y., Yoshimasa, T., Arai, H., Takaya, K., Ogawa, Y., Itoh, H. and Nakao, K. (1995). Multiple transcription of human endothelin-A receptor gene detected by reverse transcription and the polymerase chain reaction. J. Cardiovasc. Pharmacol., 26, (Suppl.), S29-S31.

72) Itoh, H. and Nakao, K. (1995). Significance of autocrine / paracrine network in renal vascular and mesangial growth. Jpn. Heart J., 36, 501.

73) Miyamoto, Y., Yoshimasa, T., Arai, H., Takaya, K., Ogawa, Y., Itoh, H. and Nakao, K. (1995). Alternative RNA splicing of human endothelin-A receptor generates multiple transcripts. Biochemical J., in press.

74) Nakagawa, M., Tanaka, I., Suga, S., Ogawa, Y., Tamura, N., Goto, M., Sugawara, A., Yoshimasa, T., Itoh, H., Mukoyama, M. and Nakao, K. (1995). Preparation of a monoclonal antibody against mouse brain natriuretic peptide (BNP) and tissue distribution of BNP in mice. Clin. Exp. Pharmacol. Physiol., (Suppl.1), S186-S187.

75) Miyoshi, Y., Nakamura, H., Sasaki, S., Tagami, T., Misaki, T., Konishi, J. and Nakao, K. (1995). Two consecutive nucleotide substitutions resulting in the T3 receptor b gene resulting in an 11-amino acid truncation in a patient with generalized resistance to thyroid hormone. Mol. Cell Endocrinol., 114, 9-17.

76) Sugiyama, S., Kugiyama, K., Matsumura, T., Suga, S., Itoh, H., Nakao, K. and Yasue. H. (1995). Lipoprotein regulate C-type natriuretic peptide secretion from cultured vascular endothelial cells. Arterioscler. Thromb. Vasc. Biol., 15, 1968-1974.

77) Goto, M., Itoh, H., Suga, S., Ogawa, Y., Kishimoto, I., Nakagawa, M., Mukoyama, M., Sugawara, A., Yoshimasa, T., Tanaka, I. and Nakao, K. (1995). Gene expression of natriuretic peptide receptor subtypes in the kidney of SHR-stroke prone. Jpn. Heart J., 36, 532.

78) Goto, M., Itoh, H., Tanaka, I., Suga, S., Ogawa, Y., Kishimoto, I., Nakagawa, M., Sugawara, A., Yoshimasa, T., Mukoyama, M. and Nakao, K. (1995). Altered gene expression of natriuretic peptide receptor subtypes in the kidney of stroke-prone spontaneously hypertensive rats. Clin. Exp. Pharmacol. Physiol., Suppl.1, S177-S179.

79) Takemura, G., Fujiwara, H., Takatsu, Y., Fujiwara, T. and Nakao, K. (1995). Venticular expression of atrial and brain natriuretic peptides in patients with myocarditis. Int. J. Cardiol., 52, 213-222.

80) Kishimoto, I., Yoshimasa, T., Arai, H., Takaya, K., Miyamoto, Y., Yamashita, J., Suga, S., Komatsu, Y., Nakagawa, O., Tanaka, I., Itho, H. and Nakao, K. (1995). Endthelin-induced activation of mitogen-activated protein kinases in glomerular mesangial cells 　　 from normotensive and stroke-prone spontaneously hypertensive rats. Clin. Exp. Pharmacol. Physiol., (Suppl.1), S207-S208.

臨床器官病態学講座 ( Clinical Sciences for Pathological Organs )

皮膚病態学分野 ( Dermatology )

1) Nishigori, C., Wang, S., Miyakoshi, J., Sato, M., Tsukada, T., Yagi, T., Imamura, S. and Takebe, H. (1994). Mutations in ras genes in cells cultured from mouse skin tumors induced by ultraviolet irradiation. Proc. Natl. Acad. Sci., 91, 7187-7193.

2) Hattori-Nakakuki, Y., Nishigori, C., Okamoto, K., Imamura, S., Hiai, H. and Toyokuni, S. (1994). Formation of 8-hydroxy-2'-deoxyguanosine in epidermis of hairless mice exposed to near-UV. Biochem. Biophy. Res. Commun., 201, 1132-1139.

3) Kitajima, T., Iwashiro, M., Kuribayashi, K. and Imamura, S. (1994). Immunological characterization of antigens on ultraviolet-light-induced tumors originating in the CB6F1 mouse. Cancer Immunol. Immunother., 38, 372-378.

4) Toichi, E., Hanada, K., Hosono, H., Hosokawa, T., Hosokawa, M., Baba, M., Imamura, S. and Takeda, T. (1994). Early decline of T cell function in humoral immunity and long-lasting inflammatory T cell activity in aging SAM mice. The SAM model of senescence (proceedings of the first international conference: The SAM Model)., 175-178.

5) Kanauchi, H., Imamura, S., Takigawa, M. and Furukawa, F. (1994). Evaluation of the Japanese Chinese herbal medicine, Kampo, for the treatment of lupus dermatoses in autoimmune prone MRL/Mp-lpr-lpr mice. J. Dermatol., 21, 935-939.

6) Kanauchi, H., Imamura, S., Takigawa, M. and Furukawa, F. (1994). Effects of cyclosporin A on lupus dermatoses in autoimmune-prone MRL/Mp-lpr-lpr mice. J. Dermatol. Treat. 5, 187-191.

7) Sawada, M., Horiguchi, Y., Abujiang, P., Miyake, N., Kitamura, Y., Midorikawa, O. Hiai, H. (1994). Monoclonal antibodies to a zinc-binding protein of rat Paneth cells. J. Histochem. Cytochem., 42, 467-472.

8) Yagi, T., Sato, M., Nishigori, C. and Takebe, H. (1994). Similarity in the molecular profile of mutations induced by UV light in shuttle vector plasmids propagated in mouse and human cells. Mutagenesis, 9, 73-77.

9) 十一英子、細川友秀、馬場満男、細川昌則、細野正道 (1995). SAMP1における加齢に伴う遅延型過敏反応低下の細胞移入実験による解析. 第11回老化促進モデルマウス (SAM) 研究協議会抄録集, 19-20.

10) 十一英子、馬場満男、細川友秀、細野正道、細川昌則 (1995). 加齢SAMP1の抗体産生と遅延型過敏反応に関わるT細胞の機能解析. 日本基礎老化学会第19 回大会講演要旨集, 121.

11) Furukawa, F. and Imamura, S. (1995). FK506: therapeutic effects on lupus dermatoses on autoimmune-prone MRL/Mp-lpr-lpr mice. Arch. Dematol. Res., 287, 558-563.

12) Kitajima, T., Iwashiro, M., Kuribayashi, K. and Imamura, S. (1995). Effects of parent genetic background on latency and antigenecity of UV-induced tumors originating in F1 hybrids. Exp. Dermatol., 4, 42-45.

臨床生体統御医学講座 ( Clinical Bioregulation )

病態代謝栄養学分野 ( Metabolism and Clinical Nutrition )

1) Kato, A., Miura, T., Yano, H., Masuda, K., Ishida, H. and Seino, Y. (1994). Suppressive effect of polygonati rhizoma on hepatic glucose output, GLUT2 mRNA expression and its protein content in rat liver. Endocrine J, 41, 139-144.

2) Kato S., Ishida, H., Tsuura, Y., Okamoto, Y., Tsuji, K., Horie, M., Okada, Y. and Seino, Y. (1994). Increased calcium channel currents of pancreatic cells in neonatally streptozotocin-induced diabetic rats. Metabolism, 43, 1395-1400.

3) Tsuura, S., Ishida, H.,Okamoto, Y., Kato, S., Horie, M., Ikeda, H. and Seino, Y. (1994). Reduced sensitivity of dihydroxyacetone on ATP-sensitive K+channels of pancreatic beta cells in GK rats. Diabetologia, 37, 1082-1087.

4) Okamoto, Y., Ishida, H., Tsuura, Y., Kato, S., Nishimura, M., Matsubara, H., Mizuno N., Usami, M. and Seino, Y. (1994). The role of cytosolic Ca2+ in the potentiation of glucose-induced insulin secretion in rat pancreatic β cells by gastric inhibitory polypeptide and cholecystokinin. Endocrinol. Metab., 1, 103-108.

5) Kagimoto, S., Yamada, Y., Yasuda, K., Kubota, A., Ihara Y., Taniguchi, T., Seino S. and Seino, Y. (1994). Somatostatin receptor subtype expression in rat,mouse and monky tissues. Endocrinol. Metab., 1, 97-101.

6) Yasuda, K., Inagaki, N., Yamada, Y., Kubota, A., Seino, S. and Seino, Y. (1994). Hamster gastric inhibitory polypeptide receptor expressed in pancreatic islets and clonal insulin-secretin cells:its structure and functional properties. Biochem. Biophys. Res. Commun., 205, 1556-1562.

7) Tanigawa. K., Kashiwada. J., Tamura. K., Kawaguchi. M., Seino. Y. and Kato, Y. (1994). Differential insulin secretory activity in rat pancreatic islets and HIT cells. Diabetes Res., 26, 1-11.

8) Tsuura, Y., Ishida, H., Hayashi, S., Sakamoto, K., Horie, M. and Seino, Y. (1994). Nitric oxide opens ATP-sensitive K+channels through suppression of phosphofructokinase activity and inhibits glucose-induced insulin release in pancreatic β cells. J. Gen. Physiol., 104, 1079-1098.

9) Ishida. H., Tsuji. K., Okamoto. Y., Tsuura. Y., Kato. S., Kurose. T., Imura. H. and Seino. Y. (1994). Functional alterations in the intracellular calcium signaling system and ion channels of pancreatic B-cells in non-insulin-dependent diabetes mellitus. In: Frontiers of Insulin Secretion and Pancreatic B-cell Research, P. R. Flatt and S. Lanzen (eds), 453-460.

10) Seino, Y., Okamoto, Y., Tsuura, Y., Kato, S., Tsuji, K. and Ishida, H. (1995). The molecular mechanisms of impaired glucose-induced insulin secretion from pancreatic β cells in non-insulin-dependent diabetes mellitus:Altered functions of ATP-sensitive K+channels and intracellular calcium signaling system. Current Trednds in Exp. Endocrinol., 2, 131-138.

11) Masuda, K., Okamoto, Y., Tsuura, Y., Kato. S., Miura, T., Tsuda, K., Horikoshi, H., Ishida, H. and Seino, Y. (1995). Effects of troglitazone (CS-045) on insulin secretion in isolated rat pancreatic islets and HIT cells: an insulinotropic mechanism distinct from glibenclamide. Diabetologia, 38, 24-30.

12) Ihara, Y., Yamada, Y., Fujii, Y., Gonoi, T., Yano, H., Yasuda, K., Inagaki, N., Seino, Y. and Seino, S. (1995). Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic β-cells. Mol. Endocrinol., 9, 121-130.

13) Miura, T., Kato, A., Usami, M., Kadowaki, S. and Seino, Y. (1995). Effect of polygonati rhizoma on blood glucose and facilitative glucose transporter isoform 2(GLUT2) mRNA expression in Wistar fatty rats. Biol. Pharm. Bull., 18, 624-625.

14) Okamoto, Y., Ishida, H., Tsuura, Y., Yasuda, K., Kato, S., Matsubara, H., Nishimura, M., Mizuno, N., Ikeda, H. and Seino, Y. (1995). Hyperresponse in calcium-induced insulin release from electrically permeabilized pancreatic islets of diabetic GK rats and its defective augmentation by glucose. Diabetologia, 38, 772-778.

15) Inagaki, N., Kuromi, H., Gonoi, T., Okamoto, Y., Ishida, H., Seino, Y., Kaneko, T., Iwanaga, T. and Seino, S. (1995). Expression and role of ionotropic glutamate receptors in pancreatic islet cells. FASEB J ., 9, 686-691.

16) Kato, S., Ishida, H., Tsuura, Y. and Seino, Y. (1995). Ion channels in β-cells of GK rats. In: Diabetes1994, S. Baba and T. Kaneko (eds), Excerpta Medica, Amsterdam, 225-227.

17) Kato, S., Ishida, H., Tsuura, Y., Tsuji, K., Nishimura, M., Horie, M., Taminato, T., Ikehara, S., Odaka, H., Ikeda, H., Okada, Y. and Seino, Y. (1996). Alterations in basal and glucose-stlmulated voltage-dependent Ca2+ channel activities in pancreatic β cells of non-insulin-dependent diabetes mellitus GK rats. J. Clin. Invest., 97, 2417-2425.

臨床病態検査学分野 ( Laboratory Medicine )

1) 須川秀夫、張美洛、山岡美奈、磯部裕美、森　徹 (1995). 実験動物を用いた人工的甲状腺機能低下症に対する当帰芍薬散、真武湯、抑肝散加陳皮半夏、温経湯の有用性についての検討. ホルモンと臨床, 医学の世界社, 43, 637-642.

2) 須川秀夫､ 上田泰行､ 上田路子､ 小杉眞司､ 赤水尚史､ 奥田譲治､ 張 美洛､ 李 華､ 森　徹 (1994). 実験的モノクローナル甲状腺刺激抗体の認識するＴＳＨ受容体上のエピトープについての解析. 日本内分泌学会雑誌, 70, 238.

3) 須川秀夫、上田路子、森　徹 (1994). 甲状腺癌特異的モノクローナル抗体TCM-9の認識する甲状腺腫瘍患者血中抗原の分画. 第53回日本癌学会総会記事, 570.

4) 須川秀夫、張美洛、上田路子、森　徹 (1994). 実験動物を用いた甲状腺機能低下病態に対する漢方薬の効果についての検討. 日本内分泌学会雑誌, 70, 744.

5) Sugawa, H.,Ueda, Y., Zhang, M., Kosugi, S., Ueda, M. and Mori, T. (1995). Determinant Spreading Shown by Monoclonal Thyroid Stimulating Antibody Produced Againt a TSH Receptor Peptide. 11th International thyroid meeting, Thyroid, 5, supple1, S-5.

6) 須川秀夫、張　美洛、小杉眞司、森　徹 (1995). ＴＳＡｂモノクローナル抗体のＴＳＨ受容体特異的 immuno-dominant 領域に対する認識性と刺激活性. 日本内分泌学会雑誌, 71, 980.

発生発達医学講座 ( Developmental Medicine )

発達小児科学分野 ( Pediatrics )

1) Hamada, Y., Hayakawa, T., Hattori, H. and Mikawa, H. (1994). Inhibitor of nitric oxide synthesis reduces neonatal hypoxic-ischemic brain damage. Pediatric Research, 35, 10-14.

2) Hayakawa, T., Hamada, Y., Maihara, T., Hattori, H. and Mikawa, H. (1994). Phenytoin reduces neonatal hypoxic-ischemic brain damage in rats. Life Sciences, 54, 387-392.

3) 服部春生、早川孝裕、武藤庫参 (1994). けいれん剤ペンチレンテトラゾールによるけいれん閾値の測定−正常および遺伝性てんかんマウスにおける測定値とその脳波所見−. 厚生省特定疾患難治性水頭症調査研究班, 平成５年度研究報告書, 86-91.

4) Hayakawa, T., Higuchi, Y., Nigami, H., Hattori, H. (1994). Zonisamide reduces hypoxic-ischemic brain damage in neonatal rats irrespective of its anticonvulsive effect. European Journal of Pharmacology, 257, 131-136.

5) 早川孝裕、服部春生、樋口嘉久、濱田　泰、毎原敏郎、仁紙宏之、奥野武彦 (1994). 低酸素・虚血性脳障害に対するフェニトインの脳保護作用−新生仔ラットモデルでの検討−. Brain Hypoxia, 8, 77-83.

6) 早川孝裕、樋口嘉久、毎原敏郎、武藤庫参、服部春生、古庄巻史、奥野武彦 (1995). 新生仔ラットの低酸素・虚血性脳障害に対するゾニザミドの脳保護作用−脳保護作用と抗けいれん作用との関係について−. Brain Hypoxia, 9, 109-117.

7) 服部春生、早川孝裕、武藤庫参 (1995). けいれん剤ペンチレンテトラゾールによるけいれん閾値の測定−先天性水頭症ＨＴＸラットにおける測定値とその脳波所見−. 厚生省特定疾患難治性水頭症調査研究班, 平成６年度研究報告, 176-179.

放射線医学講座 ( Radiology and Nuclear Medicine )

腫瘍放射線科学分野 ( Therapeutic Radiology and Oncology )

1) Mitsumori, M., Hiraoka, M., Shibata, T., Okuno, Y., Masunaga, S., Koishi, M., Okajima, K., Nagata, Y., Nishimura, Y. and Abe, M. (1994). Development of intra-arterial hyperthermia using a dextran-magnetite complex. Int. J. Hyperthermia, 10(6), 785-793.

2) Oya, N., Shibamoto, Y., Shibata, T., Sasai, K., Sugiyama, T. and Abe, M. (1994). Combined cytokinesis-block micronucleus and chromosomal aberration assay for the evaluation of radiosensitizers at low radiation doses. Int. J. Radiat. Oncol. Biol. Phys., 30(5), 1153-1159.

3) Oya, N., Shibamoto, Y., Shibata, T., Murata, R., Iwai, H., Sugiyama, T. and Abe, M. (1994). KIN-804 vs. KU-2285 as a radiosensitizer for clinical use. Int. J. Radiat. Oncol. Biol. Phys., 29(3), 595-600.

4) Shibata, T., Shibamoto, Y., Oya, N., Sasai, K., Murata, R., Ishigaki, T. and Abe, M. (1994). Comparison of radiosensitizing effect of KU-2285 and SR-2508 at low drug concentrations and doses. Int-J-Radiat-Oncol-Biol-Phys., 29(3), 587-90.

5) Shibamoto, Y., Kitakabu, Y., Murata, R., Oya, N., Shibata, T., Sasai, K., Takahashi, M. and Abe, M. (1994). Reoxygenation in the SCCVII tumor after KU-2285 sensitization plus single or fractionated irradiation. Int. J. Radiat. Oncol. Biol. Phys., 29(3), 583-6.

6) Sasai, K., Iwai, H., Yoshizawa, T., Nishimoto, S., Shibamoto, Y., Oya, N., Shibata, T. and Abe, M. (1994). Fluorinated 2-nitroimidazole derivative hypoxic cell radiosensitizers: radiosensitizing activities and pharmacokinetics. Int. J. Radiat. Oncol. Biol. Phys., 29(3), 579-82

7) Murata, R., Nishimura, Y., Hiraoka, M., Abe, M. and Satoh, M. (1995). Manganese chloride treatment does not protect against acute radiation injury of skin or crypt cells. Radiat. Res., 143(3), 316-319.

8) Oya, N., Shibamoto, Y., Sasai, K., Shibata, T., Murata, R., Takagi, T., Iwai, H., Suzuki, T. and Abe, M. (1995). Optical isomers of a new 2-nitroimidazole nucleoside analog (PR-350 series): radiosensitization efficiency and toxicity. Int. J. Radiat. Oncol. Biol. Phys., 33(1), 119-127.

核医学・画像診断学分野 ( Nuclear Medicine and Diagnostic Imaging )

1) Hosono, M., Endo, K., Hosono, M. N., Kobayashi, H., Shirato, M., Sakahara, H., Ueda, R. and Konishi, J. (1994). Treatment of small-cell lung cancer xenografts with iodine-131-anti-neural cell adhesion molecule monoclonal antibody and evaluation of absorbed dose in tissue. J. Nucl. Med., 35, 296-300.

2) Arano, Y., Inoue, T., Mukai, T., Wakisaka, K., Sakahara, H., Konishi, J. and Yokoyama, A. (1994). Discriminated release of a hippurate-like radiometal chelate in nontarget tissues for target-selective radioactivity localization using pH-dependent dissociation of reduced antibody. J. Nucl. Med., 35, 326-333.

3) Kobayashi, H., Sakahara, H., Hosono, M., Shirato, M., Kondoh, S., Miyatake, S., Kikuchi, H., Namba, Y., Endo, K. and Konishi, J. (1994). Scintigraphic detection of neural-cell-derived small-cell lung cancer using glioma-specific antibody. J. Cancer Res. Clin. Oncol., 120, 259-262.

4) Kanda, H., Mori, H., Koga, H., Taniguchi, K., Kobayashi, H., Sakahara, H., Konishi, J., Endo, K. and Watanabe, T. (1994). Construction and expression of chimeric antibodies by a simple replacement of heavy and light chain V genes into a single cassette vector. Hybridoma, 13, 359-366.

5) Kobayashi, H., Sakahara, H., Hosono, M., Yao, Z-S., Toyama, S., Endo, K. and Konishi, J. (1994). Improved clearance of radiolabeled biotinylated monoclonal antibody following the infusion of avidin as a "chase" without decreased accumulation in the target tumor. J. Nucl. Med., 35, 1677-1684.

6) 阪原晴海 (1994). 111In 標識抗体の基礎と臨床応用. 免疫核医学, 9, 8-11.

7) 小林久隆、阪原晴海、細野　真、姚　正生、遠藤啓吾、小西淳二 (1994). RI 標識ビオチン化抗体とアビジンを用いた免疫シンチグラフィのバックグラウンド低減の試み. 免疫核医学, 9, 22- 26.

8) Kobayashi, H., Sakahara, H., Endo, K., Hosono, M., Yao, Z-S., Toyama, S. and Konishi, J. (1995). Comparison of the chase effects of avidin, streptavidin, neutravidin, and avidin-ferritin on a radiolabeled biotinylated anti-tumor monoclonal antibody. Jpn. J. Cancer Res., 86, 310-314.

9) Yao, Z., Sakahara, H., Zhang, M., Kobayashi, H., Nakada, H., Yamashina, I. and Konishi, J. (1995). Scintigraphic detection of colon cancer xenografts with anti-Tn monoclonal antibody. Nucl. Med. Biol., 22, 199-203.

10) Yao, Z., Zhang, M., Kobayashi, H., Sakahara, H., Nakada, H., Yamashina, I. and Konishi, J. (1995). Improved targeting of radiolabeled streptavidin in tumors pretargeted with biotinylated monoclonal antibodies through an avidin chase. J. Nucl. Med., 36, 837-841.

11) Kobayashi, H., Sakahara, H., Endo, K., Yao, Z. S., Toyama, S. and Konishi, J. (1995). Repeating the avidin "chase" markedly improved the biodistribution of radiolabeled biotinylated antibodies and promoted the excretion of additional background radioactivity. Eur. J. Cancer, 31A, 1689-1696.

12) 阪原晴海、小林久隆、小西淳二 (1995). 核医学的手法を用いる細胞増殖因子産生腫瘍の検出と治療法の開発. INNERVISION, 10, 37.

13) 姚　正生、阪原晴海、張　美麗、小林久隆、中田　博、山科郁男、小西淳二 (1995). ビオチン化抗体と標識ストレプトアビジンによる2ステップの腫瘍イメージング：アビジン chase の効果. 免疫・腫瘍核医学, 10, 32-34.

(6)外科系専攻 ( Surgery )

器官外科学講座 ( Surgery for Visceral Organs )

消化器外科学分野 ( Gastroenterological Surgery )

1) Morimoto, T., Ukikusa, M., Taki, Y., Koizumi, K., Yokoo, N., Tanaka, A., Noguchi, M., Yamamoto, S., Nitta, N., Kamiyama, Y., Yamaoka, Y. and Ozawa, K. (1994). Changes in energy metabolism of allografts after liver transplantation. European Surgical Research., 20, 120-127.

2) Terasaki, M., Kitai, T., Kumada, K., Morimoto, T., Sasaki, H., Nakano, M., Sugano, M., Nishizawa, F., Takeuchi, E. and Ozawa, K. (1994). Hemodynamics and hepatic energy metabolism in canine model of acute hepatic venous occlusion with mesocaval shunt. European Surgical Research., 26, 19-27.

3) Sasaki, H., Higashiyama, H., Kumada, K., Morimoto, T., Tekeuchi, E. and Ozawa, K. (1994). Evaluating microscopic arterial reconstruction: A comparison of laser-assisted versus conventional vascular anastomosis in 70% hepatectomiezed rat model. European Surgical Research., 26, 35-45.

4) Sasaki, H., Yanaguchi, T., Kumada, K., Higashiyama, H., Terasaki, M., Mashima, S., Mitsuyoshi, A., Nakagami, M., Morimoto, T., Shimahara, Y. and Ozawa, K. (1994). Advantageous effect of low molecular weight heparin administration on hepatic mitochondrial redox state. Res. Exp. Med., 194, 139-145.

5) Ikai, I., Chance, B. and Kumar, C. (1994). Reactive oxygen inducing vasoconstriction in the isolated perfused rat liver. Free Rad. Biol. Med., 16, 539-545.

6) Higashiyama, H., Yamaguchi, M., Kumada, K., Sasaki, H., Yamaguchi, T. and Ozawa, K. (1994). Functional deterioration of the liver by elevated inferior vena cava pressure: a proposed upper safety limit of pressure for maintaining liver viability in dogs. Intensive Care Medicine., 20, 124-129.

7) Inomoto, T., Tanaka, A., Mori, S., Jin, M. B., Sato, B., Yanabu, N., Tokuka, A., Kitai, T., Ozawa, K. and Yamaoka, Y. (1994). Changes in the distribution of the control of the mitochondrial oxidative phosphorylation in regenerating rabbit liver. Biochimica et Biophysica Acta., 1188, 311-317.

8) Okamoto, S., Nagamatsu, K., Tokuka, A., Manaka, D., Tanaka, A., Shimabukuro, T., Ueda, M. and Yamaoka, Y. (1994). Triiodothyronine resuscitates the impaired liver function after pringle's maneuver. Archives of Surgery, 129, 851-856.

9) Mashima, S., Shiragami, G., Nakagami, M., Mitsuyoshi, A., Morimoto, T., Yamaoka, Y. and Ozawa, K. (1994) Protective effect of a PGI2 analog on intestinal microcirculation after warm ischemia. Progress in Microcirculation Research, 325-327.

10) Mori, S., Tanaka, A., Kitai, T., Sato, B., Yanabu, N., Tokuka, A., Inomoto, T., Takahashi, K., Ozawa, K. and Yamaoka, Y. (1995). Primary and reversible injury of H+-ATPase in warm ishemia and reperfusion of rat liver in relation to intramitochondrial adenine nucleotide. Journal of Surgical Research, 58, 175-181.

11) Nishizawa, F., Takada, Y., Yamaguchi, T., Mori, K., Shimahara, Y., Morimoto, T., Yamaoka, Y. and Ozawa, K. (1995). Effect of Growth Hormone on Hepatic Energy Metabolism in Normal Rabbit Liver. European Surgical Research, 27, 93-99.

12) Shirakata, Y., Terajima, H., Mashima, S., Inomoto, T., Nishizawa, F., Sadd, S., Hong, S. J., Morimoto, T., Inamoto, T. and Yamaoka, Y. (1995). The minimum graft size for successful orthotopic partial liver transplantation in the canine model. Transplantation Proceedings, 27(1), 545-546.

13) Mitsuyoshi, A., Mashima, S., Terasaki, M., Nakagami, M., Takahashi, K., Nakano, M., Morimoto, T., Yamaoka, Y. and Ozawa, K. (1995). Surgical approach for maintaining nonischemic conditions of the liver in acute hepatic vein obstruction. Journal of Surgical Research, 58, 373-377.

14) Tanaka, A., Feng, Z., Inomoto, T., Mori, S., Yokuka, A., Shinohara, H., Kataoka, M., Yamaoka, Y. and Ozawa, K. (1995). Kinetic analysis of impaired work-cost performance in jaundiced rabbit liver. Res. Exp. Med., 195, 77-84.

15) Denno, R., Takabayashi, A., Sugano, M., Awane, M., Jin, M. B., Moromoto, T., Tanaka, K., Yamaoka, Y., Kobayashi, N. and Ozawa, K. (1995). The ratio of reduced glutathione / oxidized glutathione is maintained in the liver during short-term hepatic hypoxia. Journal of Gastroenterology, 30, 338-346.

16) Sato, B., Tanaka, A., Mori, S., Yanabu, N., Kitai, T., Tokuka, A., Inomoto, T., Iwata, S., Yamaoaka, Y. and Chance, B. (1995). Quantitative analysis of redox gradient within the rat liver acini by fluorescence images: effects of glucagon perfusion. Biochimica et Biophysica Acta, 1268, 20-26.

17) Yanabu, N., Tanaka, A., Sato, B., Mori, S., Kitai, T., Tokuka, A., Inomoto, T., Yamaoka, Y., Morikawa, S. and Inubishi. T. (1995). Evaluation of water molecules in the cold-preserved rat liver proton magnetic resonance imaging. European Surgical Research, 27, 353-362.

18) Saad, S., Kanai, M., Awane, M., Yamamoto, Y., Morimoto, T., Isselhard, W. ,Minor, T., Troidl, H., Ozawa, K. and Yamaoka, Y. (1995). Protective effect of heat shock pretreatment with heat shock protein induction before hepatic warm ischemic injury caused by Pringle's maneuver. Surgery, 118, (3), 510-516.

19) Tokuka, A., Tanaka, A., Kawanishi, S., Kitai, T. and Yamaoka, Y. (1995). Hydroxyl radical production by cold-preserved rat liver monitored by the ESR spindestruction method. Transplantation Proceedings, 27, (4), 2547-2550.

20) Sato, B., Tanaka, A., Mori, S., Yanabu, N., Kitai, T., Tokuka, A., Inomoto, T. and Yamaoka.Y. (1995). Cold preservation-induced changes in oxygen radical generation between parenchymal and nonparenchymal cells in rat liver. Research in Experimental Medicine, 195, 343-354.

婦人科学産科学分野 ( Gynecology and Obstetrics )

1) 中山貴弘、後藤康夫、夏山　知、森　崇英、野田洋一 (1994). 漢方薬のハムスター精巣上体培養細胞における蛋白合成促進作用について. 日不妊誌, 39, 278-282.

2) 野田洋一、中山貴弘、後藤康夫、森　崇英 (1994). ハムスター精巣上体培養細胞におよぼす漢方薬の生物効果. 産婦人科漢方研究のあゆみ, 11, 82-89.　

3) Nakayama, T., Noda, Y., Goto, Y. and Mori, T. (1994). Effects of visible light and other environmental factors on the production of oxygen radicals by hamster embryos. Theriogenology, 41, 499-510.

4) Nakayama, T., Noda, Y., Goto, Y., Mori, T. and Tashiro, S. (1994). Effect of hochu-ekki-to, a Japanese kampo medicine, on cultured hamster epididymal cells. Am. J. Chin. Med., 22, 301-307.

5) Goto, Y., Noda, Y., Mori, T. and Nakano, M. (1994). Effect of superoxide dismutase on mouse embryos in vitro. In Frontiers of reactive oxygen species in biology and medicine, 303-305, Asada, K., and Yoshikawa, T. (eds), Excerpta Medica, Amsterdam, London, New York and Tokyo.

6) 中山貴弘、後藤康夫、神崎秀陽、高畠桂子、姫野隆雄、高倉賢二、森　崇英 (1995).　マウスモデルを用いた子宮内膜内移植法の評価. 日受着誌, 12, 92-94.

7) 中村公彦、藤原　浩、 中山貴弘、後藤康夫、森　崇英 (1995).　マウス排卵に対するベスタチンの促進効果. 産婦治療, 71, 112.

8) Nakayama, T., Goto, Y., Kanzaki, H., Takabatake, K., Himeno, Y., Noda, Y. and Mori, T. (1995). The use of intra-endometrial embryo transfer for increasing the pregnancy rate. Hum. Reprod., 10, 1603-1608.

泌尿器病態学分野 ( Urology )

1) Mizutani, Y., Nio, Y., Fukumoto, M. and Yoshida, O. ( 1994 ). Enhanced antitumor effect of bacillus Calmette-Guerin in combination with fibrinogen on urinary bladder tumor. J. Urol., 151, 1420-1426.

2) 水谷陽一、仁尾義則、福本　学、吉田　修 ( 1994 ). BCG, フィブリノーゲン混合投与によるBCG 局所療法の抗腫瘍効果の増強. Biotherapy, 8, 301-302.

心臓血管外科学分野 ( Cardiovascular Surgery )

1) Park, C.H., Nishimura, K., Kitano, M., Okamoto, Y. and Ban, T. (1994). Right Ventricular Performance is Impaired by Full Assist of Left Heart Bypass.Analysis of Right Ventricular Performance against Change in Afterload in Heart Failure Models. ASAIO Journal, 40, M303-308.

2) Park, C.H., Nishimura, K., Yamada, T., Mizuhara, H., Akamatsu, T., Tsukiya, T., Matsuda, K. and Ban, T(1994). A Magnetically Suspended Centrifugal Pump In Vitro and In Vivo Assessment. ASAIO Jounal, 41, M345-350.

3) Kitano, M., Nishimura, K., Park, C.H., Okamoto, Y. and Ban, T. (1995). Right ventricular function evaluated by volumetric analysis during left heart bypass in a canine model of postishcemic cardiac dysfunction. J. Thorac. Cardiovasc. Surg. 109, 796-803.

4) Park, C.H., Nishimura, K., Yamada, T., Mizuhara, H., Akamatsu, T., Tsukiya, T., Matsuda, K. and Ban, T. (1995). Development of a magnetically suspended centrifugal pump -in vitro and in vivo assessment-. ASAIO Jounal, 41, M345-350.

5) Yamada, T., Nomoto, S., Aota, M., Nishimura, K., Matsuda, K. and Ban, T. (1995). Hepatic circulation during nonpulsatile cardiopulmonary bypass. ASAIO Journal, 41, M294-297.

6) Mizuhara, H., Koshiji, T., Nishimura, K., Nomoto, S., Matsuda, K., Tsutsui, N., Kanda, K. and Ban, T. (1995). Applicability of the latissimus dorsi muscle in situ position as a biomechanical energy source. ASAIO Jounal, 41, M495-499.

7) 北野　満、朴　昌禧、西村和修、岡本好史、伴　敏彦 (1994). 正常及び急性心不全モデルにおける左心補助による右心機能の実験的研究 -コンダクタンスカテーテルの右心室への応用-. 日胸外会誌, 42, 1320-1329.

8) 朴　昌禧、北野　満、西村和修、岡本好史、伴　敏彦 (1994). 左心補助中の右心機能 -コンダクタンスカテーテルを用いた圧容積関係からの評価-. 人工臓器, 23, 76-81.

9) 腰地孝昭、織田禎二、西村和修、岡本好史、伴　敏彦 (1994). 腹直筋を用いた心外膜形成術 (Pericardiomyoplasty) による急性期心補助効果についての実験的検討. 人工臓器, 23, 3-7.

10) 腰地孝昭、水原寿夫、織田禎二、西村和修、岡本好史、伴　敏彦 (1995). 腹直筋を用いた骨格筋ポンプ機能. 人工臓器, 24, 401-404.

11) 朴　昌禧、西村和修、野本慎一、松田捷彦、岡本好史、赤松映明、築谷朋典、伴　敏彦 (1995). 長期使用を目的にした新しい遠心ポンプ（磁気浮上ポンプ）の in-vitro における性能評価. 人工臓器, 24, 809-814.

12) 水原寿夫、腰地孝昭、青田正樹、西村和修、野本慎一、松田捷彦、岡本好史、筒井宣政、神田克巳、伴　敏彦 (1995). 補助循環の動力源としての広背筋下挿入型ポンプの基礎的検討. 人工臓器, 24, 391-394.

臨床病態生理学分野 ( Anesthesia )

1) Shibata, M., Shingu, K., Murakawa, M., Adachi, T., Osawa, M., Nakao, S. and Mori, K. (1994). Tetraphasic actions of local anesthetics on central nervous system electrical activities in cats. Reg. Anesth., 19, 255-263.

2) Kurata, J., Nakao, S., Murakawa, M., Adachi, T., Shichino, T. and Mori, K. (1994). The cerebral cortex origin of enflurane-induced generalized seizure in cats. Anesth. Analg., 79, 713-718.

3) Kakuyama, M., Hatano, Y., Nakamura, K., Toda, H., Terasako, K., Nishiwada, M. and Mori, K. (1994). Halothane and enflurane constrict canine mesenteric arteries by releasing Ca2+ from intracellular Ca2+ stores. Anesthesiology, 80, 1120-1127.

4) Osawa, M., Shingu, K., Murakawa, M., Adachi, T., Kurata, J., Seo, N., Murayama, T., Nakao, S. and Mori, K. (1994). Effects of sevoflurane on central nervous system electrical activity in cats. Anesth. Analg., 79, 52-57.

5) Nakamura, K., Toda, H., Terasako, K., Kakuyama, M., Hatano, Y., Mori, K. and Kangawa, K. (1995). Vasodilative effect of adrenomedullin in isolated arteries of the dog. Jpn. J. Pharmacol., 67, 259-262.

感覚運動系病態学講座 ( Surgery for Sensory and Motor Systems )

筋・骨格系病態学分野 ( Orthopaedic and Musculoskeletal Surgery )　　　　　　

1) Ikenaga, M., Ohura, K., Kotoura, Y., Yamamuro, T., Nakamura, T., Oka, M., Hiraoka, M. and Abe, M. (1994). Hyperthermic treatment of canine tibia through RF inductive heating of an intramedullary nail; A new experimental approach to hyperthermia for metastatic bone tumor. International Journal of Hyperthermia, 10-4, 507-516.

2) Neo, M., Nakamura, T., Ohtsuki, C., Kasai, R., Kokubo, T. and Yamamuro, T. (1994). Ultrastructural study of the A-W GC-bone interface after long-term implantation in rat and human bone. Journal of Biomedical Material Research, 28, 365-372.

3) Fujimori, Y., Shimizu, K., Nakagawa, Y., Yamamoto, S. and Yamamuro, T. (1994). Immunohistochemical demonstration of calcium-dependent cysteine proteinae (calpain) in collagen-induced arthritis in mice. Zeitschrift fur Rheumatologie, 53, 72-75.

4) Kitsugi, T., Yamamuro, T., Nakamura, T., Oka, M., Kokubo, T., Okunaga K. and Shibuya T. (1995). Scanning electron microscopy-electron probe microanalysis study of the interface between apatite and wollastonite-containing glass-ceramic and rabbit tibia under load-bearing conditions after long-term implantation. Calcif. Tissue Int., 56, 331-335.

5) Takatsuka, K., Yamamuro, T., Nakamura, T. and Kokubo, T. (1995). Bone-bonding behaviour of titanium alloy evaluated mechanically with detaching failure load. Journal of Biomedical Materials Research, 29, 157-163.

6) Tamura, J., Kawanabe, K., Yamamuro, T., Nakamura, T., Kokubo, T., Yoshihara, S. and Shibuya, T. (1995). Bioactive bone cement: The effect of amount of glass powder and histologic changes with time. Journal of Biomedical Materials Research, 29, 551-559.

7) Kitsugi, T., Yamamuro, T., Nakamura, T. and Oka, M. (1995). Influence of disodium (1-hydroxythylidene) diphosphonate on bone ingrowth into porous, titanium fiber-mesh implants. The Journal of Arthroplasty, 10-2, 245-253.

8) Kitsugi, T., Nakamura, T., Oka, M., Cho, S. B., Miyaji, F. and Kokubo, T. (1995). Bone-bonding behaviour of three heat-treated silica gels implanted in mature rabbit bone. Calcif. Tissue Int., 57, 155-160.

9) Tamura, J., Kitsugi, T., Fujita, H., Nakamura, T., Kokubo, T., Yoshihara, S. and Shibuya T. (1995). Bone-bonding behaviour of three types of bioactive bone cement containing bioactive glass or glass-ceramic powder. Bioceramics, 8, 219-223.

10) Yasuda, T., Shimizu, K. and Nakamura, T. (1995). Effects of dexamethasone on terminal differentiation and matrix mineralization in rat growth plate chondrocyte cultures. Dexamethazone on Chondrocytes, 16-5,319-325.

11) Li, Z. I., Kitsugi, T., Yamamuro, T., Chang, Y. S., Senaha, Y., Takagi, H., Nakamura, T. and Oka, M. (1995). Bone-bonding behavior under load-bearing conditions of an alumina ceramic implant incorporating beads coated with glass-ceramic containing apatite and wollastonite. Journal of Biomedical Materials Research, 29, 1081-1088.

12) Kitsugi, T., Yamamuro, T., Nakamura, T. and Oka, M. (1995). Transmission electron microscopy observations at the interface of bone and four types of calcium phosphate ceramics with different calcium /phosphorus molar ratios. Biomaterials, 16, 1101-1107.

13) Hanahusa, S., Matsusue, Y., Yasunaga, T., Yamamuro, T., Oka, M., Shikinami, Y. and Ikada, Y. (1995). Biodegradable plate fixation of rabbit femoral shaft osteotomies, A comparative study. Clinical Orthopaedics, 315, 262-271.

14) Matsusue, Y., Hanahusa, S., Yamamuro, T. and Shikinami, Y. (1995). Tissue reaction of bioabsorbable ultra high strength poly (L-Lactide) rod. A long-term study in rabbits. Clinical Orthopaedics and Related Research, 317, 246-253.

15) Niibayashi, H., Shimizu, K., Suzuki, K., Yamamoto, S., Yasuda, T. and Yamamuro. T. (1995). Proteoglycan degradation in hemarthrosis. Intraarticular, autologous blood injection in rat knees. Acta Orthop. Scand., 66, 1, 73-79.

視覚病態学分野 ( Ophthalmology and Visual Science )

1) Yoshida, M., Yoshimura, N., Hangai, M., Tanihara, H. and Honda, Y. (1994). Interleukin-1 alpha, interleukin-1 beta, and tumor necrosis factor gene expression in endotoxin-induced uveitis. Invest. Ophthalmol. Vis. Sci., 35, 1107-1113.

2) Mandai, M., Yoshimura, N., Yoshida, M., Iwaki, M. and Honda, Y. (1994). The role of nitric oxide synthase in endotoxin-induced uveitis: effects of NG-nitro L-arginine. Invest. Ophthalmol. Vis. Sci., 35, 3673-3680.

3) 板谷正紀、万代道子、本田孔士、吉村長久 (1994). ラット虚血再潅流網膜における一酸化窒素合成酵素の遺伝子発現について. 厚生省特定疾患網膜脈絡膜萎縮症調査研究班, 平成5年度研究報告書, 86-88.

4) 吉村長久、板谷正紀、万代道子、本田孔士 (1994). ラット虚血再潅流網膜におけるインテーロイキン-1と腫瘍壊死因子の遺伝子発現について. 厚生省特定疾患網膜脈絡膜萎縮症調査研究班, 平成5年度研究報告書, 83-85.

5) Hangai, M., Yoshimura, N., Yoshida, M., Yabuuchi, K. and Honda, Y. (1995). Interleukin-1 gene expression in transient retinal ischemia in the rat. Invest. Ophthalmol. Vis. Sci., 36, 571-578.

6) Nishiwaki, H., Ogura, Y., Kimura, H., Kiryu, J. and Honda, Y. (1995). Quantitative evaluation of leukocyte dynamics in retinal microcirculation. Invest. Ophthalmol. Vis. Sci., 36, 123-130.

7) 秋元正行、小岸淳一、栗山晶治、吉村長久、本田孔士 (1995). Subtractive hybridization 法を用いた RCS ラット培養網膜色素上皮細胞における貪食能欠損関連 cDNAの同定. 厚生省特定疾患網膜脈絡膜萎縮症調査研究班, 平成6年度研究報告書, 24-25.

8) 小岸淳一、秋元正行、栗山晶治、万代道子、吉村長久、本田孔士 (1995). ラット培養網膜色素上皮細胞の視細胞外節貪食作用は一酸化窒素合成酵素阻害剤によって阻害される. 厚生省特定疾患網膜脈絡膜萎縮症調査研究班, 平成6年度研究報告書, 26-27.

9) 西脇弘一、小椋祐一郎 (1995). 白血球による網膜微小循環の評価. 臨床眼科, 49, 1393-1397.

10) 小椋祐一郎 (1995). 網膜血流とその調節. 眼科診療プラクテｲス「眼科診療に必要な生理学」, 174-180, 本田孔士編, 文光堂, 東京.

聴覚・言語病態学分野 ( Hearing and Speech Science )

1) 塩見洋作、辻　純、内藤　泰、庄司和彦、児嶋久剛、本庄　巖 (1994). 低出力レーザーの内耳に及ぼす効果. 耳鼻臨床, 87, 1135-1140.

2) 内藤　泰、内藤恵理、本庄　巖、塩見洋作、辻　純 (1994). チンチラ前庭求心及び遠心神経の選択的標識. Equilibrium Res., 53, 398-403.

3) Tsuji, J., Ito, J., Naito, Y. and Honjo, I. (1994). Effect of caloric stimulation on primary vestibular fibers originating from otolith organs in the guinea pig. Eur. Arch. Otorhinolaryngol., 251, 48-51.

(7)分子医学系専攻 ( Molecular Medicine )

遺伝医学講座 ( Medical Genetics )

腫瘍外科学分野 ( Surgery and Surgical Basic Science )

1) Kan, N., Mise, K., Nakanishi, M., Okino, T., Harada, T., Ichinose, Y., Moriguchi, Y., Sugie, T., Li, L. and Imamura, M. (1994). The induction of murine tumor infiktrating lymphocytes (TIL) by interleukin-2 or T cell growth factor. Biotherapy, 6, 303-309.

2) Harada, T., Kan, N., Ichinose, Y., Moriguchi, Y., Li, L., Sugie, T., Okino, T. and Imamura, M. (1994). The synergistic antitumor effect of recombinant interleukin-1 and low-dose of cyclophosphamide in tumor-bearing mice. J. Surg. Oncol., 56, 39-45.

3) Harada, T., Kan, N., Okino, T., Ichinose, Y., Moriguchi, Y., Li, L., Sugie, T., Ohgaki, K. and Imamura, M. (1994). Sequential immunotherapy using interleukin-1 followed by interleukin-2 of ascitic MOPC104E-bearing mice. Biotherapy, 7, 91-99.

4) Harada, T., Kan, N., Okino, T., Ichinose, Y., Moriguchi, Y., Li, L., Sugie, T., Ohgaki, K. and Imamura, M. (1994). The induction of specific antitumor immunity by in vivo treatment with interleukin-1 and sonicated tumor extract in a murine model. Surgery today, 24, 561-563.

5) Mise, M., Arii, S., Higashitsuji, H., Furutani, M., Monden, K., Adachi, Y., Funaki, N., Fujita, S., Ishiguro, S., Kitao, T., Nakamura, T., Fujita, J., Nakayama, H. and Imamura, M. (1994). Augmented local immunity in the liver by a streptococcal preparation, OK-432, related to antitumor activity of hepatic macrophages. Immunopharmacology. 27. 31-41.

6) Furutani, M., Arii S., Monden, K., Adachi, Y., Funaki, N., Higashitsuji, H., Fujita, S., Mise, M., Ishiguro, S., Kitao, T., Nakamura, T., Imamura, M., Tamatani, T., Miyasaka, M., Nakayama, H. and Fujita, J. (1994). Immunological activation of hepatic macrophages in septic rats: A possible mechanism of sepsis-associated liver injury. J. Lab. Clin. Med., 123, 430-435.

7) Ishiguro, S., Arii, S., Monden, K., Adachi, Y., Funaki, N., Higashitsuji, H., Fujita, S., Furutani, M., Mise, M., Kitao, T., Nakamura, T., Ushikubi, F., Nakamura, K., Narumiya, S. and Imamura, M. (1994). Identification of the thromboxane A2 receptor in hepatic sinusoidal endothelial cells and its role in endotoxin-induced liver injury in rats. Hepatology, 20, 1281-1286.

8) Funaki, N., Arii, S., Monden, K., Sasaoki, T., Adachi, Y., Higashitsuji, H., Tanaka, J. and Imamura, M. (1994). Chemical mediators release and surface marker expression of hepatic macrophages in rats with CCl4-induced liver cirrhosis. Life Sciences. 54, 2071-2082.

9) Arii, S., Monden, K., Adachi, R., Zhang, W., Higashitsuji, H., Furutani, M ., Mise, M., Fujita, S., Nakamura, T. and Imamura, M. (1994). Pathogenic role of Kupffer cell activation in the reperfusion injury of cold-preserved liver. Transplantaion, 58, 1072-1077.

10) Hosotani, R., Doi, R., Gu, Y-J., Wada, M., Inoue, K., Fujii, N., Rayford, P. L. and Imamura, M. (1994). Metabolism of CCK-33 in vivo: effect of L-364,718, a CCK receptor antagonist. Ann. Clin. Lab. Sci., 24, 346-354.

11) Echigo, Y., Inoue, K., Kogire, M., Higashide, S., Sumi, S., Doi, R., Takaori, K., Hayasi, H., Tun, T., Uchida, K. and Imamura, M..(1994). Deteriorating influence of immunosuppressants on caerulein-induced pancreatitis in mice. Biomedical Research, 15, 171-173.

12) Sumi, S., Inoue, K., Kitagawa, K., Echigo, Y., Imamura, M. and Tamura, K. (1994). Effect of synthetic cionin and its dusulfated derivatives on exocrine pancreatic secretion and blood flow in dogs. Biomedical Research. 15, 397-400.

13) Gu, Y-J., Inoue, K., Shinohara, S., Doi, R., Kogire, M., Aung, T., Sumi, S., Imamura, M., Fujisato, T., Maetani, S. and Ikada, Y. (1994). Xenotransplantation of bioartificial pancreas using a mesh-reinforced polyvinyl alcohol bag. Cell Taransplantation. 3, 19-21.

14) Arii, S., Monden, K., Adachi, Y., Furutani, M., Mise, M., Fujita, S., Ishiguro, S., Nakamura, T., Harada, T., Niwano, N., Ishigami, S., Mizumoto, M. and Imamura, M. (1995) Suppression of the reperfusion injury of cold-preserved livers by Kupffer cell blockade. Transplant. Proc., 27, 765-767.

15) Monden, K., Arii, S., Ishiguro, T., Nakamura, S., Fujita, S., Mise, M., Niwano, M., Sasaoki, T. and Imamura, M.( 1995). Involvement of ICAM-1 expression on sinusoidal endothelial cell and neutrophil adherence in the reperfusion injury of cold-preserved livers. Transplant. Proc., 27, 759-761.

16) Higashitsuji, H., Arii, S., Furutani, M., Imamura, M., Kaneko, Y., Takenawa, J., Nakayama, H. and Fujita, J. (1995). Enhanced expression of multiple protein tyrosine phosphatases in the regenerating mouse liver: Isolation of PTP-RL10, a novel cytoplasmic-type phosphatase with sequence homology to cytoskeletal protein 4.1. Oncogene, 10, 407-414.

17) Higashitsuji, H., Arii, S., Furutani, M., Mise, M., Monden, K., Fujita, S., Ishiguro, S., Kitao, T., Nakamura, T., Nakayama, H., Fujita, T. and Imamura, M. (1995). Expression of cytokine genes during liver regeneration after partial hepatectomy in rats. J. Surg. Res., 58, 267-274.

18) Ishiguro, S., Arii, S., Monden, K., Fujita, S., Nakamura, T., Niwano, M., Harada, T., Ushikubi, F., Narumiya, S. and Imamura, M. (1995). Involvement of thromboxane A2-thromboxan A2 receptor system of the hepatic sinusoid in the pathogenesis of the cold preservation/reperfusion injury in the liver graft of rat. Transplantation, 59, 957-961.

19) Wada, M., Doi, R., Hosotani, R., Ibuka, T., Habashita, H., Nakai, K,. Fujii, N. and Imamura, M. (1995). Effect of a bombesin receptor antagonist, (E)-alkene bombesin isostere, on amylase release from rat pancreatic acini. Pancreas, 10, 301-305.

20) Wada, M., Doi, R., Hosotani, R., Lee, J-U. and Imamura, M. (1995). Apoptosis of acinar cells in rat pancreatic duct ligation. J. Gastroenterol., 30, 301-305.

21) Echigo, Y., Inoue, K., Kogire, M., Doi, R., Higashide, S., Sumi, S., Kaji, H. and Imamura, M. (1995). Effects of cyclosporine and tacrolimus (FK 506) on acute pancreatitis in mice. Archives of Surgery, 130, 64-68.

22) Kogire, M., Inoue, K., Higashide, S., Takaori, K., Echigo, Y., Gu, Y-J., Sumi, S., Uchida, K. and Imamura, M. (1995). Protective effects of endothelin-1 on acute pancreatitis in rats. Digestive Disease and Sciences, 40, 1207-1212.

23) 和田道彦、土井隆一郎、細谷亮、李正焜、今村正之 (1995). ボンベシン受容体と膵腺房：ボンベシンの構造変換の影響. 消化管ホルモン (VIII), 医学図書出版, 38-42.

(8)脳統御医科学系専攻 ( Neuroscience )

脳病態生理学講座 ( Clinical Neuroscience )

脳神経外科学分野 ( Neurosurgery )

1) Higashi, T., Takechi, H., Uemura, Y., Kikuchi, H. and Nagata, K. (1994). Differential induction of mRNA species encoding several classes of stress proteins following focal cerebral ischemia in rats. Brain Research, 650, 239-248.

2) Iihara, K., Sasahara, M., Hashimoto, N., Uemura, Y., Kikuchi, H. and Hazama, F. (1994). Ischemia induces the expression of the platelet-derived growth factor-B chain inneurons and brain macrophages in vivo. J. Cereb. Blood Flow Metab., 14, 818-824.

3) Namura, S., Takada, M., Kikuchi, H. and Mizuno, N. (1994). Topographical organization of subicular neurons projecting to subcortical regions. Brain Research Bulletin, 35, 221-231.

4) Yanamoto, H., Kikuchi, H., Okamoto, S. and Nozaki, K. (1994). Cerebral vasospasm causedby cisternal infection of polystyrene latex beads in rabbits is inhibited by a serine protease inhibitor. Surgical Neurology, 42, 374-381.

5) 石川正恒、菊池晴彦、西澤貞彦、米倉義晴、佐治英郎 (1994). 実験的水頭症における中枢ベンゾジアゼピン レセプター・イメージング. 厚生省特定疾患難治性水頭症調査研究班, 平成5年度研究報告書, 48-52.

6) Higashi, T., Nakai, A., Uemura, Y., Kikuchi, H. and Nagata, K. (1995). Activation of heat shock factor 1 in rat brain during cerebral ischemia or after heat shock. Molecular Brain Research, 34, 262-270.

(9) 医学部附属動物実験施設 ( Institute of Laboratory Animals )

1) Hirayama, N., Kuramoto, T., Kondo, Y., Yamada, J. and Serikawa, T. (1994). Genetic profile of 12 inbred rat strains for 46 microsatellite loci selected as genetic monitoring markers. Exp. Anim., 43, 129-132.

2) Asano, A., Serikawa, T. and Yamada, J. (1994). Improvement of poor operant performance by continual intake of phenobarbital in spontaneously epileptic rats. Exp. Anim., 43, 137-140.

3) Miura, M., Yamada, T., Moralejo, D. H., Agui, T., Yamada, J., Serikawa, T. and Matsumoto, K. (1994). Chromosomal assignments of genes for rat ceruloplasmin (CP) and metallothionein (MT). Cytogenet. Cell Genet., 65, 119-121.

4) Kuramoto, T., Maihara, T., Masu, M., Nakanishi S. and Serikawa, T. (1994). Gene mapping of NMDA receptors and metabotropic glutamate receptors in the rat (Rattus norvegicus). Genomics, 19, 358-361.

5) Yamada, J., Kuramoto, T. and Serikawa, T. (1994). A rat genetic linkage map and comparative maps for mouse or human homologus rat genes. Mamm. Genome, 5, 63-83.

6) Kuramoto, T., Mori, M., Yamada, J. and Serikawa, T. (1994). Tremor and zitter, cauative mutant genes for epilepsy with spongiform encephaopathy in spontanrously epileptic rat (SER), are tightly linked to synaptobrevin-2 and prion protein genes, respectively. Biochem. Biophys. Res. Comm., 200, 1161-1168.

7) Yamada, Y., Kim, J. K., Muramatsu, Y., Serikawa, T. and Matsumoto, K. (1994). Chromosomal assignments of the genes for the calcineurin Aa (Calna1) and Ab subunits (Calna2) in the rat. Cytogenet. Cell Genet., 67, 55-57.

8) Muramatsu, Y., Yamada, T., Yamada, J., Serikawa, T. and Matsumoto, K. (1994). Chromosomal assignment of the gene for rat protein posphatase 1g1(Ppp1cc). Cytogenet. Cell Genet., 67, 58-60.

9) Kuramoto, T., Mashimo, T., Koike, R., Miyawaki, S., Yamada, J., Miyasaka, M. and Serikawa, T. (1994). The alymphoplasia (aly) mutation cosegregates with the intercellular adhesion molecule-2 (Icam-2) on mouse chromosome 11. Int. Immunol., 6, 991-994.

10) Sasaki, N., Hayashizaki, Y., Muramatsu, M., Matsuda, Y., Ando, Y., Kuramoto, T., Serikawa, T., Azuma, T., Naito, A., Agui, T., Yamashita, T., Miyoshi, I., Takechi, N. and Kasai, N. (1994). The gene responsible for LEC hepatitis, located on rat chromosome 16, is the homolog to the human Wilson disease gene. Biochem. Biophys. Res. Comm. 202, 512-518.

11) Muramatsu, Y., Yamada, T., Miura, M., Sakai, T., Suzuki, Y., Serikawa, T., Tanzi, R. E. and Matsumoto, K. (1994). Wilson's disease gene is homologous to hts causing abnormal copper transport in Long-Evans cinamon rats. Gastroenterol., 107, 1189-1192.

12) Ogawa, Y., Itoh, H., Yoshitake, Y., Inoue, M., Yoshimasa, T., Serikawa, T. and Nakao, K. (1994). Molecular cloning and chromosomal assignment of the mouse c-type natriuretic peptide (CNP) gene (Nppc) : Comparison with human CNP gene (NPPC). Genomics, 24, 383-387.

13) Yamada, T., Muramatsu, Y., Kim, J. K., Serikawa, T. and Matsumoto, K. (1994). Mapping of the gene for rat protein phosphatase 2Ca (PP2C1) to chromosome 6. Mamm. Genome, 5, 655-657.

14) Mori, M., Andoh, Y., Nojima, H. and Serikawa, T. (1994). Chromosomal mapping of calmodulin genes in the rat. Mamm. Genome, 5, 824-826.

15) Muramatsu, Y., Yamada, T., Serikawa, T. and Matsumoto, K. (1994). Mapping of the gene for rat protein phosphatase 2Cb (PP2C2) to chromosome 10. Mamm. Genome, 5, 832-833.

16) Maihara, T., Andoh, Y., Yokoi, N., Kuramoto, T. and Serikawa, T. (1995). Fifty-six new microsatellite markers in the rat genetic linkage map. Transplant. Proc., 27, 1502-1504.

17) Rosinski-Chupin, I., Kuramoto, T., Courty, Y., Rougeon, F. and Serikawa, T. (1995). Assignment of the rat variable coding sequence (VCS) gene family to chromosome 14. Mamm. Genome, 6, 153-154.

18) Katsuya, T., Takami, S., Higaki, J., Serikawa, T., Mikami, H., Miki, T. and Ogihara, T. (1995). Gap junction protein locus on chromosome 18 cosegregates with body weight in the spontaneously hypertensive rat. Hypertens. Res., 18, 63-67.

19) Kuramoto, T., Mashimo, T. and Serikawa, T. (1995). Fourteen anonymous DNA markers of laboratory rats identified with arbitrarily primed polymerase chain reaction (AP-PCR). Exp. Anim., 44, 119-125.

20) Momiyama, T., Ishihara, K., Serikawa, T., Moritake, K. and Sasa, M. (1995). Effect of nicardipine on abnormal excitability of CA3 pyramidal cells in hippocampal slices of spontaneously epileptic rats. Eur. J. Pharmacol., 280, 119-123.

21) Nagata, T., Saji, H., Nishizawa, S., Yonekawa, Y., Yamamoto, I., Iida, Y., Magaa, Y., Konishi, J., Serikawa, T., Yokoyama, A. and Morita, R. (1995). [125I] Iomazenil binding in the brains of spontaneously epileptic rats: an ex vivo quantitative autoradiographic study. Nucl. Med. Biol., 22, 445-449.

22) Sadamatsu, M., Kanai, H., Masui, A., Serikawa, T., Yamada, J. Sasa, M. and Kato, N. (1995). Altered brain contents of neuropeptides in spontaneously epileptic rats (SER) and tremor rats with absence seizures. Life Sci., 57, 523-531.

23) Muraguchi, T. and Serikawa, T. (1995). Strain differences for tossing-up induced seizures and pentylenetetrazol-induced convulsions in CXB RI strains. Mouse Genome, 93, 1035-1037.

24) Kloting, I., Vogt, L. and Serikawa, T. (1995). Locus on chromosome 18 cosegregates with diabetes in the BB/OK rat subline. Diabet. Metabol., 21, 338-344.

25) Hanaya, R., Sasa, M., Ujihara, H., Fujita, Y., Amano, T., Matsubayashi, H., Serikawa, T. and Utsumi, T. (1995). Effect of antiepileptic drugs on absence-like seizures in the tremor rat. Epilepsia, 36, 938-942,

26) Nishimura, M., Hirayama, N., Serikawa, T., Kanehira, K., Matsushima, Y., Katoh, H., Wakana, S., Kojima, A. and Hiai, H. (1995). The SMXA: a new set of recombinant inbred strain of mice consisting of 26 substrains and their genetic profile. Mamm. Genome, 6, 850-857.