Japanese
 NBRP Rat No: 0659 Strain NameF344.WIC-Tgrdw/Kts Commmon Name: rdw rat, F344-rdw
 Principal Investigator  Sen-ichi Furudate
 Organization   School of Medicine, Kitasato University Department of Laboratory Animal Sciences
 Address  1-15-1, Kitasato, Sagamihara

228-8555 Kanagawa

 Japan
 Telephone  042-778-9319  Fax:  042-778-7555  furudate@med.kitasato-u.ac.jp
 Inbred Generations   F4 
   
 Coat Color
 Deposition Status
 
 
  Embryo      Sperm      Live Animals
 Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene rdw
 Origin
 
 Strain Characteristics  
 Breeding Conditions  
 Genotyping  
 References  Shibayama K, Ohyama Y., Ono M. , Furudate S: Expression of mRNA coding for pituitary hormones and pituitary-specific transcription factor in the pituitary gland of the rdw rat with hereditary dwarfism. J. Endocrinol. 138: 307-313, 1993.
Ono M, Harigai T, Furudate S.: Pituitary-specific transcription factor Pit-1 in rdw rat with GH- and PRL- deficient dwarfism. J. Endocrinol. 143, 479-487, 1994.
Oh-Ishi M, Omori A, Kwon J-Y, Agui T, Maeda T, Furudate S: Detection and identification of proteins related to the hereditary dwarfism of the rdw rat. Endocrinology, 139 (3), 1288-1299, 1998.
Kim PS, Ding M, Menon S, Jung C-G, Cheng J-M, Miyamoto T, Li B, Furudate S , Agui T: A missence mutation G2320R in the thyroglobulin gene causes non-goitrous congenital primary hypothyroidism in the WIC-rdw rat. Mol Endocrinol 14 (12): 1944-1953, 2000
Hishinuma A, Furudate S, Oh-ishi M, Nagakubo N, Namatame T, Ieiri T: A novel missense mutation (G2320R) of the thyroglobulin gene causes hereditary hypothyroidism of the rdw rat. Endocrinology 141 (11): 4050-4055, 2000
Sakai Y., Yamashina S, Furudate S: Missing Secretory Granules, dilated Endoplasmic reticulum, and nuclear dislocation in the thyroid gland of rdw rats with hereditary dwarfism. Anat Rec 259: 60-66, 2000
Sakai Y, Yamashina S, Furudate S: Developmental delay and unstable state of the testes in the rdw rat with congenital hypothyroidism. Develop Growth Differ 46: 327-334, 2004.
Baryshev M, Sargsyan E, Wallin G, Lejnieks A, Furudate S, Hishinuma A, Mkrtchian   S: Unfolded protein response is involved in the pathology of human congenital hypothyroid goiter and rat non-goitrous congenital hypothyroidism. J Mol Endocrinol 32(3): 903-920, 2004
Oh-Nishi M, Saji M, Furudate S, Suzuki N: Dopamine D2-like receptor function is converted from excitatory to inhibitory by thyroxine in early development of hippocampus. J Neuroendocrinol 17(12), 836-845, 2005.
Furudate S, Ono M, Shibayama K, Ohyama Y, Kuwada M, Kimura Y, Kamaya T: Rescue from dwarfism by thyroid function conpensation in rdw rats. Exp Anim 54 (5), 455-460. 2005
Menon S, Lee J, Abplanalp WA, Yoo S-E, Agui T, Furudate S, Kim PS, Arvan P: Oxidoreductase interactions include a role for ERp72 engagement with mutant thyroglobulin from the rdw/rdw rat dwarf. J Bio Chem 282(9):6183-91. 2007
Oh-Ishi M, Kodera Y, Furudate S, Maeda T: Disease proteomics of endocrine disorders revealed by two-dimensional gel electrophoresis and mass spectrometry. Proteomics Clin Appl 2008 2: 327-337.