Japanese
NBRP Rat No: 0669
Strain Name
:
F344.Cg-
Du Tyr
C
/Kyo
Commmon Name: downunder rat
Principal Investigator
Takashi Kuramoto
Organization
Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
Address
Yoshidakonoe-cho, Sakyo-ku
606-8501 Kyoto
Japan
Telephone
075-753-4494
Fax: 075-753-4409
kuramot@anim.med.kyoto-u.ac.jp
Inbred Generations
N8F2
Coat Color
Deposition Status
downunder
Embryo
Sperm
Live Animals
Usage Restrictions
The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.
Genetic Status
Inbred
Segregating
Congenic
Consomic
Recombinant
Coisogenic
Spont. Mutant
Transgene
Ind. Mutant
Others
Comercial Availability
Research Category
Diabetes Obesity
Neurobiology
Ophthalmology
Dentistry
Cardio- Hypertension
Oncology
Metabolism
Otorhinology
Immunology
Infectious Disease
Osteology
Internal Medicine
Dermatology
Reproduction
Development
Behavior
Hematology
Urology
Pharmacology
Others
Control Strains
Reporter gene Strains
Gene
Origin
This strain with Downunder (Du) mutation is originated from a male fancy rat (Coming Home. This rat was introduced from U.S.A. on July 13th, 2005.). F1 generation was obtained by crossing with TM/Kyo female. A F3 male rat (#313) was crossed with WTC/Kyo and we obtained F3+1 (18/10/2006). The sperms were collected from a F3+4 rat.
Strain Characteristics
Heterozygous rats (downunder rat) have patchy pattern on their back and the same pattern is also obserbe on their abdominal skin hair. This rare hair color pattern is observed when they have a hooded mutation. This phenotype is dominant inheritance and homozygous rats are embryonic lethal.
Breeding Conditions
maintained by crossing between Du/+ (downunder) and +/+ (hooded). Tyrosinase allele: C/C
Genotyping
The causative gene is unknown.
References
Genetic analyses of fancy rat-derived mutations.
Kuramoto T, Yokoe M, Yagasaki K, Kawaguchi T, Kumafuji K, Serikawa T.
Exp Anim. 2010;59(2):147-55.