Strain Characteristics |
A convincing line of evidence is being developed that the congenital nongoitrous hypothyroidism and dwarfism observed in the WIC-<i>rdw</i> rat may indeed be caused by a primary defect in thyroid hormonogenesis. In support of this hypothesis, several recent reports have shown the presence of elevated molecular chaperone levels in the WIC-<i>rdw</i> thyrocytes, the endoplasmic reticulum of which was markedly dilated, suggesting a defect in intracellular protein transport. It was reported that A missense mutation, G2320R, in the Tg gene is responsible for the rdw mutation in the WIC-<i>rdw</i> rat. |
References |
Shibayama K, Ohyama Y, Ono M, Furudate S Expression of mRNA coding for pituitary hormones and pituitary-specific transcription factor in the pituitary gland of the rdw rat with hereditary dwarfism. J Endocrinol. 138: 307-313, 1993.
Ono M, Harigai T, Furudate S. Pituitary-specific transcription factor Pit-1 in rdw rat with GH- and PRL- deficient dwarfism. J. Endocrinol. 143, 479-487, 1994.
Oh-Ishi M, Omori A, Kwon JY, Agui T, Maeda T, Furudate S. Detecion and identication of proteins related to the hereditary dwarfism of the rdw rat. Endocrinology 139(3): 1288-1299, 1998.
Hishinuma A, Furudate S, Oh-ishi M, Nagakubo N, Namatame T, Ieiri T A novel missense mutation (G2320R) of the thyroglobulin gene causes hereditary hypothyroidism of the rdw rat. Endocrinology 141 (11): 4050-4055, 2000.
Sakai Y, Yamashina S, Furudate S Missing Secretory Granules, dilated Endoplasmic reticulum, and nuclear dislocation in the thyroid gland of rdw rats with hereditary dwarfism. Anat Rec 259: 60-66, 2000.
Kim PS, Ding M, Menon S, Jung C-G, Cheng J-M, Miyamoto T, Li B, Furudate S, Agui T A missence mutation G2320R in the thyroglobulin gene causes non-goitrous congenital primary hypothyroidism in the WIC-rdw rat. Mol Endocrinol 14 (12): 1944-1953, 2000. |