NBRP Rat No: 0024 Strain NameZI/Kyo Commmon Name: ZI, zitter rat
 Principal Investigator  Tadao Serikawa
 Organization   Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
 Address  Yoshidakonoe-cho, Sakyo-ku

606-8501 Kyoto

 Telephone  075-753-4360  Fax:  075-753-4409  serikawa@anim.med.kyoto-u.ac.jp
 Inbred Generations   F13+42 (March 2012) 
 Coat Color
 Deposition Status
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Atrn: attractin
 Origin Zitter rat was detected in a Sprague Dawley colony (SD) in Hannover in 1978 by Rehm. 1983 introduced to Kyoto University and established ZI. (Jan 26, 2010) 
 Strain Characteristics ZI strain develops a generalized body tremor at about 15 days of age, and with increasing age a progressive flaccid paresis of the hind limb occurs (Rehm, 1982). The main pathological findings are hypomyelination and vacuolation in the central nervous system (Rehm, 1982, Kondo, 1991). By positional cloning, a marked decrease in <i>Atrn</i> mRNA in the brain of the ZI rat and zi as an 8-bp deletion at a splice donor site of intron 12 of <i>Atrn</i> were found (Kuramoto, 2001). (Jun 19, 2009) 
 Breeding Conditions Good breeding performance. 
 Genotyping <a href="http://www.anim.med.kyoto-u.ac.jp/nbr/documents/PCR_Gene/Atrn_zi_en.pdf">Genotyping protocol for Atrn</a> 
 References  Kuramoto T, Kitada K, Inui T, Sasaki Y, Ito K, Hase T, Kawagachi S, Ogawa Y, Nakao K, Barsh GS, Nagao M, Ushijima T, Serikawa T.
Attractin/Mahogany/Zitter plays a critical role in myelination of the central nervous system.
Proc Natl Acad Sci USA, 98 (2): 559-564, 2001.

Ueda S, Sakakibara S, Watanabe E, Yoshimoto K, Koibuchi N.
Vulnerability of monoaminergic neurons in the brainstem of the zitter rat in oxidative stress.
Prog Brain Res. 136:293-302, 2002.

Joyce JN, Yoshimoto K, Ueda S.
The zitter mutant rat exhibits loss of D3 receptors with degeneration of the dopamine system.
Neuroreport. 2000 Jul 14;11(10):2173-5.

Ueda S, Aikawa M, Ishizuya-Oka A, Yamaoka S, Koibuchi N, Yoshimoto K.
Age-related dopamine deficiency in the mesostriatal dopamine system of zitter mutant rats: regional fiber vulnerability in the striatum and the olfactory tubercle.
Neuroscience. 2000;95(2):389-98.

Muto Y, Hayashi T, Higashi Y, Endo T, Yamamoto T, Sato K.
Age-related decrease in brain-derived neurotrophic factor gene expression in the brain of the zitter rat with genetic spongiform encephalopathy.
Neurosci Lett. 1999 Aug 20;271(2):69-72.

Ueda S, Aikawa M, Ishizuya-Oka A, Koibuchi N, Yamaoka S, Yoshimoto K.
Age-related degeneration of the serotoninergic fibers in the zitter rat brain.
Synapse. 1998 Sep;30(1):62-70.

Rehm S, Mehraein P, Anzil AP, Deerberg F.
A new rat mutant with defective overhairs and spongy degeneration of the central nervous system: clinical and pathologic studies.
Lab Anim Sci. 32(1):70-3, 1982.

Kondo A, Sato Y, Nagara H.
An ultrastructural study of oligodendrocytes in zitter rat: a new animal model for hypomyelination in the CNS.
J Neurocytol. 20(11):929-39, 1991.