| Strain Characteristics
||ZI strain develops a generalized body tremor at about 15 days of age, and with increasing age a progressive flaccid paresis of the hind limb occurs (Rehm, 1982). The main pathological findings are hypomyelination and vacuolation in the central nervous system (Rehm, 1982, Kondo, 1991). By positional cloning, a marked decrease in <i>Atrn</i> mRNA in the brain of the ZI rat and zi as an 8-bp deletion at a splice donor site of intron 12 of <i>Atrn</i> were found (Kuramoto, 2001). (Jun 19, 2009)
||Kuramoto T, Kitada K, Inui T, Sasaki Y, Ito K, Hase T, Kawagachi S, Ogawa Y, Nakao K, Barsh GS, Nagao M, Ushijima T, Serikawa T.
Attractin/Mahogany/Zitter plays a critical role in myelination of the central nervous system.
Proc Natl Acad Sci USA, 98 (2): 559-564, 2001.
Ueda S, Sakakibara S, Watanabe E, Yoshimoto K, Koibuchi N.
Vulnerability of monoaminergic neurons in the brainstem of the zitter rat in oxidative stress.
Prog Brain Res. 136:293-302, 2002.
Joyce JN, Yoshimoto K, Ueda S.
The zitter mutant rat exhibits loss of D3 receptors with degeneration of the dopamine system.
Neuroreport. 2000 Jul 14;11(10):2173-5.
Ueda S, Aikawa M, Ishizuya-Oka A, Yamaoka S, Koibuchi N, Yoshimoto K.
Age-related dopamine deficiency in the mesostriatal dopamine system of zitter mutant rats: regional fiber vulnerability in the striatum and the olfactory tubercle.
Muto Y, Hayashi T, Higashi Y, Endo T, Yamamoto T, Sato K.
Age-related decrease in brain-derived neurotrophic factor gene expression in the brain of the zitter rat with genetic spongiform encephalopathy.
Neurosci Lett. 1999 Aug 20;271(2):69-72.
Ueda S, Aikawa M, Ishizuya-Oka A, Koibuchi N, Yamaoka S, Yoshimoto K.
Age-related degeneration of the serotoninergic fibers in the zitter rat brain.
Synapse. 1998 Sep;30(1):62-70.
Rehm S, Mehraein P, Anzil AP, Deerberg F.
A new rat mutant with defective overhairs and spongy degeneration of the central nervous system: clinical and pathologic studies.
Lab Anim Sci. 32(1):70-3, 1982.
Kondo A, Sato Y, Nagara H.
An ultrastructural study of oligodendrocytes in zitter rat: a new animal model for hypomyelination in the CNS.
J Neurocytol. 20(11):929-39, 1991.