NBRP Rat No: 0285 Strain NameGAERS/Mave Commmon Name: GAERS, Genetic Absence Epilepsy Rats from Strasbourg
 Principal Investigator  Astrid Nehlig
 Organization   Universite Louis Pasteur INSERM U 405, Faculte de Medecine
 Address  11 rue Hunmann

67085 Strasbourg

 Telephone  +33 390 24 32 43  Fax:  +33 390 24 32 56  nehlig@neurochem.u-strasbg.fr
 Inbred Generations   F61+19 (Jun 2010) 
 Coat Color
 Deposition Status
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions  In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature designated by the DEPOSITOR is requested.
Danober L., Deransart C., Depaulis A., Vergnes M., Marescaux C. Pathophysiological mechanisms of genetic absence epilepsy in the rat. Prog. Neurobiol. 1998 May; 55 (1): 27-57. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Origin Thirty per cent of the Wistar rats from the initial breeding colony in their laboratory in Strasbourg presented spontaneous spike and wave discharges (SWDs) which were bilateral and synchronous over the cerebral cortex. A strain in which all animals displayed SWDs was selected after several generations by selecting breeders with SWDs. 
 Strain Characteristics  
 Breeding Conditions Good breeding performance. 
 References  Danober L, Deransart C, Depaulis A, Vergnes M, Marescaux C.
Pathophysiological mechanisms of genetic absence epilepsy in the rat.
Prog Neurobiol. 55(1):27-57, 1998.

Rudolf G, Thérèse Bihoreau M, F Godfrey R, P Wilder S, D Cox R, Lathrop M, Marescaux C, Gauguier D.
Polygenic control of idiopathic generalized epilepsy phenotypes in the genetic absence rats from Strasbourg (GAERS).
Epilepsia. 45(4):301-8, 2004.

Powell KL, Cain SM, Ng C, Sirdesai S, David LS, Kyi M, Garcia E, Tyson JR, Reid CA, Bahlo M, Foote SJ, Snutch TP, O'Brien TJ.
A Cav3.2 T-type calcium channel point mutation has splice-variant-specific effects on function and segregates with seizure expression in a polygenic rat model of absence epilepsy.
J Neurosci. 2009 Jan 14;29(2):371-80.

Mohammad Rafiqul ISLAM, Jafri Malin ABDULLAH
Age-dependent Electroencephalographic Differences in the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) Model of Absence Epilepsy.
Malays J Med Sci. 2014 Dec; 21(Spec Issue): 34–40.

Serikawa T, Mashimo T, Kuramoto T, Voigt B, Ohno Y, Sasa M.
Advances on Genetic Rat Models of Epilepsy.
Exp Anim. 64(1):1-7, 2015.