Japanese
 NBRP Rat No: 0372 Strain Name: MPOD/Kyo Commmon Name: MPOD, Myeloperoxidase deficient rat
 Principal Investigator  Tadao Serikawa
 Organization   Graduate School of Medicine, Kyoto University Institute of Laboratory Animals
 Address  Yoshidakonoe-cho, Sakyo-ku

606-8501 Kyoto

  JAPAN
 Telephone  075-753-4360  Fax:  075-753-4409  serikawa@anim.med.kyoto-u.ac.jp
 Inbred Generations   F8+5 (May 2009) 
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin Myeloperoxidase deficient rat was detected in Std:Wistar rats which were purchased from Japan SLC, Inc. in 2001. The causative gene is inherited as an autosomal recessive trait. 
 Strain Characteristics Compared with normal rats, 1) female sexual maturation is late (about 20 weeks of age), 2) growing of progeny is late and poor lactation leads to death at an age of 2 or 3 days of age because of poor lactation, 3) litter size is small (about 5), 4) infant weight gain is reduced. (Nov 4, 2009) 
 Breeding Conditions Maintained by sib mating among homozygoutes which shows possitive peroxidase activity. 
 Genotyping  
 References  1. Sequence of the murine myeloperoxidase(MPO) gene; Venturelli, D. et al, Nucleic Acids Research Vol.17(19),7987-7988,1989

2. 公開特許公報　特開2000-116280（2000年4月25日公開）　発明の名称：ミエロペルオキシダーゼ遺伝子機能が欠損しているマウス