Japanese
 NBRP Rat No: 0458 Strain Name: F344-Adms/Kyo Commmon Name: ADMS(autosomal dominant myokymia and seizures)rat, KER(Kyoto Epileptic Rat), Boo
 Principal Investigator  Tomoji Mashimo
 Organization    The University of Tokyo, The Institute of Medical Science Laboratory Animal Research Center
 Address  4-6-1 Shirokanedai-Minatoku-Tokyoto

108-8639 

  Japan
 Telephone  03-6409-2489  Fax:    mashimo@ims.u-tokyo.ac.jp
 Inbred Generations   N7 (May 2009) 
   
 Coat Color
 Deposition Status
 
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions   The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.  
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene
 Origin This strain was established by phenotype-driven ENU mutagenesis. 
 Strain Characteristics ADMS rats dominantly exhibited myokymia, neuromyotonia and generalized tonic-clonic seizures. They also showed cold stress-induced tremor, neuromyotonia, and motor incoordination.<br />Key words: myokymia, neuromyotonia, epilepsy 
 Breeding Conditions Good breeding performance until seizure onset (about 4 or 5 months of age). Heterozygous females have less performance of nursing behavior for their pups. 
 Genotyping <a href="http://www.anim.med.kyoto-u.ac.jp/nbr/documents/PCR_Gene/kcna1m1.pdf">Genotyping protocol for Kcna1</a> 
 References  Serikawa T, Mashimo T, Kuramoto T, Voigt B, Ohno Y, Sasa M.
Advances on Genetic Rat Models of Epilepsy.
Exp Anim. 64(1):1-7, 2015.

Ishida S, Sakamoto Y, Nishio T, Baulac S, Kuwamura M, Ohno Y, Takizawa A, Kaneko S, Serikawa T, Mashimo T.
Kcna1-mutant rats dominantly display myokymia, neuromyotonia and spontaneous epileptic seizures.
Brain Res. 2012 Jan 30;1435:154-66.