Strain information

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NBRP Rat No: 0458

Strain name: F344-Adms/Kyo

Commmon Name: ADMS(autosomal dominant myokymia and seizures)rat, KER(Kyoto Epileptic Rat), Boo

Rat Genome Database

Principal Investigator:

Tomoji Mashimo The University of Tokyo, The Institute of Medical Science

Preservation Status:

Embryo Sperm Living Animals

Coat Color

albino (c)

Inbred Generations

N7 (May 2009)

Usage Restrictions

The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.
For a commercial use of this resource, a new contract must be concluded between the depositor and the recipient.

Genetic Status

Inbred Segregating Congenic Consomic Recombinant Coisogenic Spont. Mutant Transgene Ind. Mutant Category Other

Comercial Availability

Research Category

Diabetes Obesity Neurobiology Ophthalmology Dentistry Cardio Hypertension Cancer Metabolism Otorhinology Immunology Infectious Osteosis Internal Organ Dermatology Reproduction Development Behavior Hematology Urology Pharmacology Research Area Others

Control Strain Marker Strain

Gene Affected

Origin

This strain was established by phenotype-driven ENU mutagenesis.

Strain characteristics

ADMS rats dominantly exhibited myokymia, neuromyotonia and generalized tonic-clonic seizures. They also showed cold stress-induced tremor, neuromyotonia, and motor incoordination.
Key words: myokymia, neuromyotonia, epilepsy

Breeding Conditions

Good breeding performance until seizure onset (about 4 or 5 months of age). Heterozygous females have less performance of nursing behavior for their pups.

Genotyping

Genotyping protocol for Kcna1

References

Serikawa T, Mashimo T, Kuramoto T, Voigt B, Ohno Y, Sasa M.
Advances on Genetic Rat Models of Epilepsy.
Exp Anim. 64(1):1-7, 2015.

Ishida S, Sakamoto Y, Nishio T, Baulac S, Kuwamura M, Ohno Y, Takizawa A, Kaneko S, Serikawa T, Mashimo T.
Kcna1-mutant rats dominantly display myokymia, neuromyotonia and spontaneous epileptic seizures.
Brain Res. 2012 Jan 30;1435:154-66.

Additional strain information (Japanese only)