NBRP Rat No: 0290 Strain NameICR/Ihr Commmon Name: ICR, Ihara's cataract rat, Inherited cataract rat
 Principal Investigator  Nobuo Ihara
 Organization   Institute of ICR research 
 Address  3-17, 4-chome, Matsuigaoka, Kyotanabe-city

610-0353 Kyoto

 Telephone  0774-62-6448  Fax:  0774-65-1123  
 Inbred Generations   F?+1+12 (April 2012) 
 Coat Color
 Deposition Status
 albino (c)
  Embryo      Sperm      Live Animals
 Usage Restrictions  The recipient of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITORS. The recipient is requested to confer with DEPOSITORS, before publication, about the report on the investigated results obtained by using the RESOURCE. 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Origin The ICR is a hereditary cataractous strain developed by selective breeding by Ihara et al. of Kansai Medical University (Ihara, 1983). Ihara's cataract rat, Inherited cataract rat. (Oct 12, 2010) 
 Strain Characteristics ICR rats exhibit spontaneous cataract at 3-4 months of age and mature it completely at 4-6 months of age (Ihara 1983). The cataractous change is progressive. In the lenses of ICR rats, increase of Ca<sup>2+</sup> content with the decrease of Ca<sup>2+</sup>-ATPase activity, remarkable decrease of some kind of beta- and gamma-crystallin content, increase of C-terminal truncated alpha-crystallin, increase of NO and lipid peroxide (LPO) level, and accumulation of autolytic products by calpain are recognized (Takeuchi, 2000; Takeuchi, 2001; Takeuchi, 2004; Nagai, 2008). Eye drops with antibiotic DSF delays the lens opacification in ICR rats (Nagai, 2007; Nagai, 2008). The etiology of the cataract in ICR rats is different from that in UPL rats (NBRP No. 0217) and that in diabetic models (Nagai, 2008). (Oct 12, 2010) 
 Breeding Conditions  
 References  Ihara N.
A new strain of rat with an inherited cataract.
Experientia. 15;39(8):909-11, 1983.

Takeuchi N, Kamei A.
Crystallin proteins in lenses of hereditary cataractous rat, ICR/f.
Biol Pharm Bull. 2000 Mar;23(3):283-90.

Takeuchi N, Ouchida A, Kamei A.
C-terminal truncation of alpha-crystallin in hereditary cataractous rat lens.
Biol Pharm Bull. 2004 Mar;27(3):308-14.

Takeuchi N, Ito H, Namiki K, Kamei A.
Effect of calpain on hereditary cataractous rat, ICR/f.
Biol Pharm Bull. 2001 Nov;24(11):1246-51.

Nagai N, Ito Y, Takeuchi N.
Inhibitive effects of enhanced lipid peroxidation on Ca(2+)-ATPase in lenses of hereditary cataract ICR/f rats.
Toxicology. 2008 May 21;247(2-3):139-44.

Nagai N, Takeda M, Ito Y, Takeuchi N, Kamei A.
Delay in ICR/f rat lens opacification by the instillation of eye drops containing disulfiram and hydroxypropyl-beta-cyclodextrin inclusion complex.
Biol Pharm Bull. 2007 Aug;30(8):1529-34.

Nagai N, Ito Y, Takeuchi N.
Effect of disulfiram eye drops on lipid peroxide formation via excessive nitric oxide in lenses of hereditary cataract ICR/f rats.
Biol Pharm Bull. 2008 May;31(5):981-5.