Strain Characteristics |
ICR rats exhibit spontaneous cataract at 3-4 months of age and mature it completely at 4-6 months of age (Ihara 1983). The cataractous change is progressive. In the lenses of ICR rats, increase of Ca<sup>2+</sup> content with the decrease of Ca<sup>2+</sup>-ATPase activity, remarkable decrease of some kind of beta- and gamma-crystallin content, increase of C-terminal truncated alpha-crystallin, increase of NO and lipid peroxide (LPO) level, and accumulation of autolytic products by calpain are recognized (Takeuchi, 2000; Takeuchi, 2001; Takeuchi, 2004; Nagai, 2008). Eye drops with antibiotic DSF delays the lens opacification in ICR rats (Nagai, 2007; Nagai, 2008). The etiology of the cataract in ICR rats is different from that in UPL rats (NBRP No. 0217) and that in diabetic models (Nagai, 2008). (Oct 12, 2010) |
References |
Ihara N. A new strain of rat with an inherited cataract. Experientia. 15;39(8):909-11, 1983.
Takeuchi N, Kamei A. Crystallin proteins in lenses of hereditary cataractous rat, ICR/f. Biol Pharm Bull. 2000 Mar;23(3):283-90.
Takeuchi N, Ouchida A, Kamei A. C-terminal truncation of alpha-crystallin in hereditary cataractous rat lens. Biol Pharm Bull. 2004 Mar;27(3):308-14.
Takeuchi N, Ito H, Namiki K, Kamei A. Effect of calpain on hereditary cataractous rat, ICR/f. Biol Pharm Bull. 2001 Nov;24(11):1246-51.
Nagai N, Ito Y, Takeuchi N. Inhibitive effects of enhanced lipid peroxidation on Ca(2+)-ATPase in lenses of hereditary cataract ICR/f rats. Toxicology. 2008 May 21;247(2-3):139-44.
Nagai N, Takeda M, Ito Y, Takeuchi N, Kamei A. Delay in ICR/f rat lens opacification by the instillation of eye drops containing disulfiram and hydroxypropyl-beta-cyclodextrin inclusion complex. Biol Pharm Bull. 2007 Aug;30(8):1529-34.
Nagai N, Ito Y, Takeuchi N. Effect of disulfiram eye drops on lipid peroxide formation via excessive nitric oxide in lenses of hereditary cataract ICR/f rats. Biol Pharm Bull. 2008 May;31(5):981-5. |