Japanese
 NBRP Rat No: 0511 Strain Name: ZDF-Leprfa/CrlCrlj Commmon Name: ZDF, ZDF/CrlCrlj
 Principal Investigator  Shinya Takahashi
 Organization   Charles river laboratories Japan 
 Address  11F 3-17-16 Shinyokohama, Kouhokuku, Yokohama

222-0033 Kanagawa

  Japan
 Telephone  045（474）9340  Fax:  045（474）9341  web_order@jp.crl.com
 Inbred Generations    
   
 Coat Color
 Deposition Status
 
 Four principal coat color Variants
  Embryo      Sperm      Live Animals
 Usage Restrictions   
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Lepr: leptin receptor
 Origin Some rats of colony of outbred Zucker rats kept in Eli Lilly Research Laboratories were transferred to Indiana University Medical School in 1977. Selection and inbreeding was performed in 1981 and inbred ZDF strain was established in 1985. To Charles River Laboratories, Inc. in 2001. To Charles River Japan, Inc. in 2005. Zucker Diabetic Fatty. (May 28, 2010) 
 Strain Characteristics The ZDF rat is an animal model for obese, type 2 diabetes.
When fed with a diet of Purina 5008, homozygous males (<i>Lepr<sup>fa</sup></i>/<i>Lepr<sup>fa</sup></i>) develop obesity, hyperlipidemia, fasting hyperglycemia, and Type 2 diabetes. Wildtype (+/+) and heterozygous (<i>Lepr<sup>fa</sup></i>/+) lean genotypes remain normoglycemic. (May 28, 2010) 
 Breeding Conditions Homozygous rats are infertile. (May 28, 2010) 
 Genotyping  
 References