Japanese
 NBRP Rat No: 0476 Strain Name: LEC.W-Tg(CAG-Zfml)26Ncms/Ncms Commmon Name: LEC.Wistar-Tg(CAG-Zfml)26Ncms/Ncms, LEC.Wistar-<i>Tg(CAG-Np220)26Ncms</i>, Np220トランスジェニックラット
 Principal Investigator  Ichiro Miyoshi
 Organization   Nagoya City University Graduate School of Medical Sciences Center for Experimental Animal Science
 Address  1 Kawasumi Mizuho-cho, Mizuho-ku, Nagoya

466-8601  Aichi

  Japan
 Telephone  052-853-8109  Fax:   052-841-6187  msd0831@hotmail.com
 Inbred Generations   F10 
   
 Coat Color
 Deposition Status
 
 cinnamon
  Embryo      Sperm      Live Animals
 Usage Restrictions  In publishing, a citation of the following literature(s) designated by the DEPOSITOR is requested.
 
 Genetic Status   Inbred   Segregating   Congenic   Consomic    Recombinant 
  Coisogenic   Spont. Mutant    Transgene   Ind. Mutant    Others 
 Comercial Availability   
 Research Category   Diabetes Obesity    Neurobiology    Ophthalmology    Dentistry    Cardio- Hypertension 
  Oncology   Metabolism   Otorhinology    Immunology    Infectious Disease
  Osteology    Internal Medicine   Dermatology   Reproduction    Development
  Behavior    Hematology    Urology   Pharmacology   Others 
  Control Strains   Reporter gene Strains  
 Gene Zfml (Zfp638): zinc finger protein 638
 Origin CAG promoter driven Zfml cDNA isolated from BN strain was injected into Crlj:WI (Wistar). Thereafter this congenic strain was established by backcrossing the transgenic rats to LEC rats for 10 generation. (Oct 30, 2009) 
 Strain Characteristics On the hypothesis that Zfml is the causative gene for radiation sensitivity of LEC rats, rescue analysis using transgenic rats was conducted. But the transgenic rats showed no change of the radiation sensitivity and it appeared that Zfml was not the causative gene. (Oct 30, 2009) 
 Breeding Conditions  
 Genotyping  
 References